DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Asap and AGAP5

DIOPT Version :9

Sequence 1:NP_001014504.1 Gene:Asap / 35783 FlyBaseID:FBgn0050372 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001137472.1 Gene:AGAP5 / 729092 HGNCID:23467 Length:686 Species:Homo sapiens


Alignment Length:574 Identity:131/574 - (22%)
Similarity:211/574 - (36%) Gaps:166/574 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 EYYHALSNYFKDGLQTIEHF--GTYIGDLSEKLHEIKQKQDEDRR-------------------- 265
            :.|.:.|..|.|.....:|:  .|.|....|..|.|.|: |.||.                    
Human   140 QQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQR-DADRSLSIPDEQLHSFAVSTVHITK 203

  Fly   266 ------SLLDLRTVLRSTPDFERVD---------NVPSSESRSGGAGYSLHQLQGDKH------- 308
                  ||.:..:.:.|||...:.|         |.|:...:......:|...:...|       
Human   204 NRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSHPDKERKA 268

  Fly   309 ---HGVT---------RQGHLLKKSEGKVRRVWQKRRCRVTSDGFLDIF----------HADESK 351
               |..|         :||.|||:| ||..:.|:|:...:.|:|.|..:          |..|  
Human   269 PENHADTIGSGRAIPIKQGMLLKRS-GKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKE-- 330

  Fly   352 PPTRVNLLTCQIK--------------PVPDDK-------------------------------- 370
                ::|.|..||              |:...|                                
Human   331 ----IDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNP 391

  Fly   371 -----------------RGFDLIS-YNRPYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQHANPQ 417
                             ..|.::| ..:.:||:|....::.||:..:    :..:..:.|.....
Human   392 PPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI----QSQILASLQSCESS 452

  Fly   418 MSPSLVELQK--TVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRI 480
            .|.|.:..|.  ..::.:|.:.||..|.|..::|. .|.|||.|:|:||:|||:||.||...||:
Human   453 KSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNP-KWASLNLGVLMCIECSGIHRSLGTRLSRV 516

  Fly   481 QSLTLDNLTTANLLIARAMGNSTLNDIME-AKLGRGKLQHESSMEERYDFIRAKYVAKRYVMRTC 544
            :||.||:.......:..::||...|.|.| :..|:.|...:|:.||:..:||:||..|.::....
Human   517 RSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLP 581

  Fly   545 SDDNDLRCDLEQAVVNADMSQLLQVWAEGA----DLTCCLPSSDAGETALHLAVLREMGSTLHIV 605
            ..:..|...|.:|..:.|:...:.:.|.|:    :.||   ....|.||||||..:  |:.:   
Human   582 CTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETC---GEGDGCTALHLACRK--GNVV--- 638

  Fly   606 DFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYE 659
              |.|.:...|::....     |..| ||||........:||:.:||:.|...|
Human   639 --LAQLLIWYGVDVMAR-----DAHG-NTALTYARQASSQECINVLLQYGCPDE 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsapNP_001014504.1 BAR_ASAPs 35..249 CDD:153288 7/27 (26%)
PH_ASAP 302..410 CDD:270071 31/200 (16%)
ArfGap_ASAP 425..541 CDD:350063 43/118 (36%)
Ank_2 554..662 CDD:403870 30/110 (27%)
ANK repeat 586..622 CDD:293786 11/35 (31%)
ANK repeat 624..662 CDD:293786 12/36 (33%)
Ank_2 636..>693 CDD:403870 7/24 (29%)
SH3_ASAP 1095..1149 CDD:212755
AGAP5NP_001137472.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..242 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..278 3/21 (14%)
PH_AGAP 280..447 CDD:241281 28/177 (16%)
PH 283..442 CDD:278594 28/169 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..404 0/21 (0%)
ArfGap 466..580 CDD:279720 42/114 (37%)
ANK <590..677 CDD:238125 26/102 (25%)
Ank_2 591..681 CDD:289560 28/105 (27%)
ANK repeat 591..621 CDD:293786 7/32 (22%)
ANK repeat 623..654 CDD:293786 11/42 (26%)
ANK 1 623..652 11/35 (31%)
ANK 2 656..685 11/30 (37%)
ANK repeat 656..681 CDD:293786 9/25 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D751525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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