DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Asap3

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_038967221.1	Gene:	Asap3 / 684122	RGDID:	1593929	Length:	903	Species:	Rattus norvegicus

Alignment Length:	980	Identity:	350/980 - (35%)
Similarity:	509/980 - (51%)	Gaps:	123/980 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPT-TSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSG 66
            |..::|:||:..|..|.|||. .:.||::||.||......||.||.|:..|.::||||:|||:||
  Rat     2 PEQLSVAEFLAVTAEDLSSPAGAAAFAAKMPRCRGAALAREEVLEGDQAILQRIKKAVRAIHSSG 66

  Fly    67 NTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSM 131
            ..||:.|.....|:|.||...:.|:..::...||..:|.|:|::||.|.|:||:||||.||:|::
  Rat    67 LGHVETEEHYREAVEALGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDNL 131

  Fly   132 LKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQ 196
            :|..||..:.|.|:..:||.||||.|..|:|||:.......|      ....::::.::|||::|
  Rat   132 MKGHLRDGRHDSKKHLEKAWKDYETKVAKLEKERDRARFPGG------SHGAMSQDTQRERRVFQ 190

  Fly   197 LQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQD 261
            |..||||:|..:.:.|.|.:.||.||:::||..|:|:||.:..:....:|..|:..:|.::|.|:
  Rat   191 LHMCEYLVKAGESQVKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLSPFIDKLAASVHGLRQAQE 255

  Fly   262 EDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVR 326
            |:...|..||..||.....|..:..|:  .::.|.|||:||.||:|..|..:.|.|.|||:| :|
  Rat   256 EELHKLTQLRDSLRGMLHLESREEHPN--RKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDG-IR 317

  Fly   327 RVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGD 391
            ||||||:|.| ..|.|.|.|:..::||.::.|||||::|.|:|||.|||:::||.|||.||||.:
  Rat   318 RVWQKRKCGV-KYGCLTISHSMVNRPPVKLALLTCQVRPNPEDKRCFDLVTHNRTYHFHAEDELE 381

  Fly   392 QKAWMAVLVNCKEKALTKAFQHANP---------QMSPSLVELQKTVIRYVQLLPGNDRCCDCGS 447
            .:||::||.|.|::||:.|| |..|         ::.....:|...::..|:..||||.|||||:
  Rat   382 CEAWVSVLQNSKDEALSSAF-HGEPSGGQWSWGTRLDTEPHDLTNMLVAEVKSRPGNDHCCDCGA 445

  Fly   448 RNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKL 512
            . |.||:|.|.|:|.|||||||||:|||.:|||||||||.|..:.||:|..:|||..|::|||.|
  Rat   446 A-DPTWLSTNLGVLTCIQCSGVHRELGVRYSRIQSLTLDLLGPSELLLALNIGNSHFNEVMEAHL 509

  Fly   513 ---GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGA 574
               |..|...||.|..|.::|.||||..::..|:..:...||    .|:.:.|:..:|:.:|.|.
  Rat   510 PSHGSPKPSAESDMSSRRNYIVAKYVEHKFARRSTPEPQKLR----TAICSRDLLSVLEAFANGQ 570

  Fly   575 DLTCCLPSSDA---GETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGK--NT 634
            |....||..|.   ||.|||||:.....::|.||||||||            .|.||....  ||
  Rat   571 DFGQLLPGPDGQAPGELALHLAIRVASQASLPIVDFLIQN------------GGHLDAKAADGNT 623

  Fly   635 ALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFD-HI 698
            |||..|||.:.:|:||||:..|.....|:..:||||:|:...|..|.||:|.| :....||. .:
  Rat   624 ALHCAALHGQLDCLKLLLKGRAPMGAVNNAGETALDVARNKQHKDCEELLEQA-QAGTLAFPLPM 687

  Fly   699 NTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSR 763
            :..|....:.|    .|.|...:|:....:||:.|...|..|...:.|.::: ::..|.:: .|:
  Rat   688 DYHWGHSMDHG----FDSEEEEEEKHCPVKPPAQACWSSGRLDISNRTYETV-ANPGPTSS-QSQ 746

  Fly   764 QFTLPSGLPSYTHS-------AGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAA 821
            ....|..||....|       ||.|.:....:......:.....|     .|||:|:||
  Rat   747 SEDSPPPLPIKNSSRTILLGRAGDSSRDRSDIPSLRSESPEASEN-----RSSPASSSS------ 800

  Fly   822 RNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAP------PPGTL--GSASSSSFYGTLPHP 878
              |.....:.||                 ..:..|:|      ||||.  |.||     ||.|..
  Rat   801 --SFTSSVEPGG-----------------LSQALPSPEESLQEPPGTSRPGLAS-----GTTPAE 841

  Fly   879 PRHSQNFDASDIRAINHKNQSL-DVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGG--SGNGSNN 940
            ......|.:...|:.....::| |.....||..|                ...|.|  .|:||..
  Rat   842 VYLPVRFSSESTRSYRRGGRNLEDGPAARLPLCR----------------RNIPVGLMEGDGSKI 890

  Fly   941 SLMPA 945
            .::||
  Rat   891 GVLPA 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	82/213 (38%)
		PH_ASAP	302..410	CDD:270071	56/107 (52%)
		ArfGap_ASAP	425..541	CDD:350063	62/118 (53%)
		Ank_2	554..662	CDD:403870	42/112 (38%)
		ANK repeat	586..622	CDD:293786	16/35 (46%)
		ANK repeat	624..662	CDD:293786	17/39 (44%)
		Ank_2	636..>693	CDD:403870	23/56 (41%)
		SH3_ASAP	1095..1149	CDD:212755
Asap3	XP_038967221.1	BAR_ASAP3	35..243	CDD:153324	82/213 (38%)
		PH_ASAP	294..400	CDD:270071	56/107 (52%)
		ArfGap_ASAP3	423..543	CDD:350087	62/120 (52%)
		ANK repeat	550..583	CDD:293786	11/36 (31%)
		ANK repeat	585..618	CDD:293786	19/44 (43%)
		Ank_2	589..674	CDD:403870	40/96 (42%)
		ANK repeat	620..651	CDD:293786	14/30 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920