DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and asap3

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001352027.1	Gene:	asap3 / 664764	ZFINID:	ZDB-GENE-050913-39	Length:	991	Species:	Danio rerio

Alignment Length:	1192	Identity:	415/1192 - (34%)
Similarity:	598/1192 - (50%)	Gaps:	245/1192 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..|::|:||...:.|.|||.:|.|.|:|.|||.|:..|||.||.|:..|.|:||.||||||||.
Zfish     2 PEKISISDFVSLAKEDLSSPGSSGFQSKMSDCRSTVAALEESLEQDQMSLQKMKKIVKAIHNSGL 66

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            .||:|:......||.||...:.||..::...||..:|.|:|::||.|.|:||:|||:.||::::|
Zfish    67 NHVENKEQYTEVLENLGNSHLSQDNNEVSTGFLNLAVFTREVTALFKNLVQNLNNIISFPLENVL 131

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |||||..:.::|:..:|:.|||:||..|:|||::.:.|:.|::|  :|....||:||:|||.:||
Zfish   132 KSELRDSRLELKKQMEKSWKDYDAKIGKLEKERREKQKQHGLIR--LDMTDTAEDMERERRNFQL 194

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||||.:::|.:.|.:|||.||:|:.|..|:|:|||:..|:.|.::..|:..:|.::.:|||
Zfish   195 QMCEYLLKIQELKIRQGPDLLQGLIKYFQAQLNFFQDGLKAAENLGPFVEKLAASVHTVRHEQDE 259

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESR-SGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVR 326
            :.:.|..||..||:.   .:||......:| :.|.|||:||.||:|.:|..:.|.|||||:| :|
Zfish   260 EVKQLSQLRDSLRTQ---LQVDGKEDFLNRKNSGHGYSIHQPQGNKKYGTEKSGFLLKKSDG-IR 320

  Fly   327 RVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGD 391
            :|||||:|.| ..|.|.|.|:..::||.::||||||::|.|::||.|||:::||.||||||||.:
Zfish   321 KVWQKRKCGV-KYGCLTISHSTINRPPAKLNLLTCQVRPNPEEKRTFDLVTHNRTYHFQAEDEQE 384

  Fly   392 QKAWMAVLVNCKEKALTKAFQHANPQMSPS-LVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWIS 455
            ...|::||.|.||:||..|......|...| |.||.:.||..::.||||:.|||||: .|.||:|
Zfish   385 CMIWVSVLQNSKEEALNTALGGDQLQFQDSGLQELVRAVISGLRNLPGNESCCDCGA-PDPTWLS 448

  Fly   456 LNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRGKLQ-- 518
            .|.|||.||:|||:||:||||.|||||||||.|:|:.||:|.::||:..|||||..|....::
Zfish   449 TNLGILTCIECSGIHRELGVHQSRIQSLTLDVLSTSELLLAVSIGNARFNDIMEVNLPNDAVKPL 513

  Fly   519 HESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLT--CCLP 581
            .:|.|..|.::|.|||..:|||:   ..::.....:...|.:.|:..|||.:|||.||:  ..:|
Zfish   514 PKSDMTARKEYIVAKYAERRYVL---PKEHSEAYRVFDTVRSKDLVSLLQHYAEGEDLSKPVAIP 575

  Fly   582 -SSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD---VTGKNTALHLCALH 642
             ..|..||.|||||.....::|.:||||.||            .|.|:   |.| |||||.|||:
Zfish   576 DGQDLKETGLHLAVRMSDKTSLALVDFLAQN------------CGCLEKKTVEG-NTALHYCALY 627

  Fly   643 DRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNE 707
            .:.||:||||::.|.....||..:|||||||.:.|..|.||:|.|...:.::..|:...|.:|.
Zfish   628 KKTECLKLLLKAKAVLHTVNSAGETALDIAKRLQHMQCIELLELAHSGKFNSQIHVEYTWEMPQ- 691

  Fly   708 DGSTDFSDDETVIDERK------SRS-RPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQF 765
                |..|.|..:|||.      ||| .||:...|.          |.|..:.:.   :||:|.:
Zfish   692 ----DMYDSEDDLDERASPHPKVSRSPLPPTGVNGH----------CSSAWNLNK---SCPARTY 739

  Fly   766 TLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSD 830
                              ::|   .:|  ..|...|....||..|....:::::..|:...:...
Zfish   740 ------------------ENI---DFL--YRNPPNNSAPTGGHMPPPLPAKAIQRGRSDPQISGS 781

  Fly   831 L---------GGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPR-HSQNF 885
            :         ..|.||..:..||.             ||...|           |.|.| ||...
Zfish   782 IPETHTPYRQSSHPTGCFQKISTT-------------PPEPCG-----------PTPARSHSTGP 822

  Fly   886 DASDIRAINHKNQSLDVAYGTLPHLRSVESSPRG--------------GGGYGYGVSQDPGGSGN 936
            .....:.:..:.|....|.|. .|..|.:|. ||              ||..|.|.:..||.:|:
Zfish   823 SKGQRQTVFWEGQPFSGAEGK-NHSTSPQSQ-RGPVSSEKTTSYRRTSGGSQGKGSAPSPGYAGS 885

  Fly   937 GSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRPKIPPPGPP 1001
            .......||       .:|:....|.|..:|           :|.|            :|||
Zfish   886 QEELYCSPA-------SNPAPPPANANNSVA-----------VPVL------------LPPP--- 917

  Fly  1002 SEREISNGQSNESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESNVSSSDN 1066
                  ..:.|..||..:.     |:|:
Zfish   918 ------RSRKNAMISLRER-----PKKV------------------------------------- 934

  Fly  1067 DRLNSSPDNPSKTGGAGLGGKFHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWM 1131
                                          :||.||.|...:.|.|.:.|::||  ..|||.:|.
Zfish   935 ------------------------------KALVDCRAVGANHLAFFKNEVIIV--TATDDPHWW 967

  Fly  1132 EGIIEGQPTRKGMFPVSFVHML 1153
            .|.|||:|:|.|.|||::||.|
Zfish   968 VGHIEGEPSRSGTFPVNYVHKL 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	98/213 (46%)
		PH_ASAP	302..410	CDD:270071	57/107 (53%)
		ArfGap_ASAP	425..541	CDD:350063	62/117 (53%)
		Ank_2	554..662	CDD:403870	45/113 (40%)
		ANK repeat	586..622	CDD:293786	14/35 (40%)
		ANK repeat	624..662	CDD:293786	19/40 (48%)
		Ank_2	636..>693	CDD:403870	27/56 (48%)
		SH3_ASAP	1095..1149	CDD:212755	24/53 (45%)
asap3	NP_001352027.1	BAR_ASAP3	34..246	CDD:153324	98/213 (46%)
		PH_ASAP	297..403	CDD:270071	57/107 (53%)
		ArfGap	421..537	CDD:307528	62/119 (52%)
		ANK repeat	582..614	CDD:293786	16/43 (37%)
		ANK	<583..669	CDD:238125	44/98 (45%)
		ANK repeat	616..647	CDD:293786	16/31 (52%)
		Herpes_gI	<749..>858	CDD:332941	26/134 (19%)
		SH3	933..985	CDD:327375	25/120 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm24323
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.920