Protein Alignment Asap and asap3

DIOPT Version :10

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001352027.2
• Gene: asap3 / 664764
• ZFINID: ZDB-GENE-050913-39
• Length: 991
• Species: Danio rerio
• Alignment Length: 1192
• Identity: 415/1192 - (34%)
• Similarity: 598/1192 - (50%)
• Gaps: 245/1192 - (20%)

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..|::|:||...:.|.|||.:|.|.|:|.|||.|:..|||.||.|:..|.|:||.||||||||.
Zfish     2 PEKISISDFVSLAKEDLSSPGSSGFQSKMSDCRSTVAALEESLEQDQMSLQKMKKIVKAIHNSGL 66

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            .||:|:......||.||...:.||..::...||..:|.|:|::||.|.|:||:|||:.||::::|
Zfish    67 NHVENKEQYTEVLENLGNSHLSQDNNEVSTGFLNLAVFTREVTALFKNLVQNLNNIISFPLENVL 131

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |||||..:.::|:..:|:.|||:||..|:|||::.:.|:.|::|  :|....||:||:|||.:||
Zfish   132 KSELRDSRLELKKQMEKSWKDYDAKIGKLEKERREKQKQHGLIR--LDMTDTAEDMERERRNFQL 194

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||||.:::|.:.|.:|||.||:|:.|..|:|:|||:..|:.|.::..|:..:|.::.:|||
Zfish   195 QMCEYLLKIQELKIRQGPDLLQGLIKYFQAQLNFFQDGLKAAENLGPFVEKLAASVHTVRHEQDE 259

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESR-SGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVR 326
            :.:.|..||..||:.   .:||......:| :.|.|||:||.||:|.:|..:.|.|||||:| :|
Zfish   260 EVKQLSQLRDSLRTQ---LQVDGKEDFLNRKNSGHGYSIHQPQGNKKYGTEKSGFLLKKSDG-IR 320

  Fly   327 RVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGD 391
            :|||||:|.| ..|.|.|.|:..::||.::||||||::|.|::||.|||:::||.||||||||.:
Zfish   321 KVWQKRKCGV-KYGCLTISHSTINRPPAKLNLLTCQVRPNPEEKRTFDLVTHNRTYHFQAEDEQE 384

  Fly   392 QKAWMAVLVNCKEKALTKAFQHANPQMSPS-LVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWIS 455
            ...|::||.|.||:||..|......|...| |.||.:.||..::.||||:.|||||: .|.||:|
Zfish   385 CMIWVSVLQNSKEEALNTALGGDQLQFQDSGLQELVRAVISGLRNLPGNESCCDCGA-PDPTWLS 448

  Fly   456 LNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRGKLQ-- 518
            .|.|||.||:|||:||:||||.|||||||||.|:|:.||:|.::||:..|||||..|....::
Zfish   449 TNLGILTCIECSGIHRELGVHQSRIQSLTLDVLSTSELLLAVSIGNARFNDIMEVNLPNDAVKPL 513

  Fly   519 HESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLT--CCLP 581
            .:|.|..|.::|.|||..:|||:   ..::.....:...|.:.|:..|||.:|||.||:  ..:|
Zfish   514 PKSDMTARKEYIVAKYAERRYVL---PKEHSEAYRVFDTVRSKDLMSLLQHYAEGEDLSKPVAIP 575

  Fly   582 -SSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD---VTGKNTALHLCALH 642
             ..|..||.|||||.....::|.:||||.||            .|.|:   |.| |||||.|||:
Zfish   576 DGQDLKETGLHLAVRMSDKTSLALVDFLAQN------------CGCLEKKTVEG-NTALHYCALY 627

  Fly   643 DRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNE 707
            .:.||:||||::.|.....||..:|||||||.:.|..|.||:|.|...:.::..|:...|.:|.
Zfish   628 KKTECLKLLLKAKAVLHTVNSAGETALDIAKRLQHMQCIELLELAHSGKFNSQIHVEYTWEMPQ- 691

  Fly   708 DGSTDFSDDETVIDERK------SRS-RPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQF 765
                |..|.|..:|||.      ||| .||:...|.          |.|..:.:.   :||:|.:
Zfish   692 ----DMYDSEDDLDERASPHPKVSRSPLPPTGVNGH----------CSSAWNLNK---SCPARTY 739

  Fly   766 TLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSD 830
                              ::|   .:|  ..|...|....||..|....:::::..|:...:...
Zfish   740 ------------------ENI---DFL--YRNPPNNSAPTGGHMPPPLPAKAIQRGRSDPQISGS 781

  Fly   831 L---------GGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPR-HSQNF 885
            :         ..|.||..:..||.             ||...|           |.|.| ||...
Zfish   782 IPETHTPYRQSSHPTGCFQKISTT-------------PPEPCG-----------PTPARSHSTGP 822

  Fly   886 DASDIRAINHKNQSLDVAYGTLPHLRSVESSPRG--------------GGGYGYGVSQDPGGSGN 936
            .....:.:..:.|....|.|. .|..|.:|. ||              ||..|.|.:..||.:|:
Zfish   823 SKGQRQTVFWEGQPFSGAEGK-NHSTSPQSQ-RGPVSSEKTTSYRRTSGGSQGKGSAPSPGYAGS 885

  Fly   937 GSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRPKIPPPGPP 1001
            .......||       .:|:....|.|..:|           :|.|            :|||
Zfish   886 QEELYCSPA-------SNPAPPPANANNSVA-----------VPVL------------LPPP--- 917

  Fly  1002 SEREISNGQSNESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESNVSSSDN 1066
                  ..:.|..||..:.     |:|:
Zfish   918 ------RSRKNAMISLRER-----PKKV------------------------------------- 934

  Fly  1067 DRLNSSPDNPSKTGGAGLGGKFHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWM 1131
                                          :||.||.|...:.|.|.:.|::||  ..|||.:|.
Zfish   935 ------------------------------KALVDCRAVGANHLAFFKNEVIIV--TATDDPHWW 967

  Fly  1132 EGIIEGQPTRKGMFPVSFVHML 1153
            .|.|||:|:|.|.|||::||.|
Zfish   968 VGHIEGEPSRSGTFPVNYVHKL 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	98/213 (46%)
		PH_ASAP	302..410	CDD:270071	57/107 (53%)
		ArfGap_ASAP	425..541	CDD:350063	62/117 (53%)
		ANKYR	<573..709	CDD:440430	56/141 (40%)
		ANK repeat	586..622	CDD:293786	14/35 (40%)
		ANK repeat	624..662	CDD:293786	19/40 (48%)
		Vac17	<706..>788	CDD:435863	18/88 (20%)
		SH3_ASAP	1095..1149	CDD:212755	24/53 (45%)
asap3	NP_001352027.2	None