DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Acap2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_017453554.1	Gene:	Acap2 / 619382	RGDID:	1562939	Length:	816	Species:	Rattus norvegicus

Alignment Length:	866	Identity:	193/866 - (22%)
Similarity:	331/866 - (38%)	Gaps:	240/866 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTH-VDNEMFM 76
            ||...|  ||   .|.:.:.:....:..||.:|:       ||.|...|:.::|... ..|:.||
  Rat     8 EECLKD--SP---RFRAALEEVEGDVAELELKLD-------KLVKLCIAMIDTGKAFCAANKQFM 60

  Fly    77 --VRALERLGGK--VIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELR 137
              :|.|.:....  |:|       .:..|||...:|:......|.......:...:.:.:|.:||
  Rat    61 NGIRDLAQYSSNDAVVE-------TSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLR 118

  Fly   138 GVKGDMKRPFDKAAKDYEAKFIK---IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQT 199
            ..| |.|:.|:|.:::.|...:|   :::.|:.:.:||..:.|            ..|:.::...
  Rat   119 KFK-DAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEAANILT------------ATRKCFRHIA 170

  Fly   200 CEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEI-----KQK 259
            .:|:|:...:::|...|:|:.::.:.:|...:|..|.......|.|:.||..:|..:     |:|
  Rat   171 LDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEK 235

  Fly   260 QD-EDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEG 323
            :: |.:.|.:..:..|:   ||...|              |..:...|..:|:..:|:|.|::..
  Rat   236 REMEQKHSTIQQKAALQ---DFSSDD--------------SKLEYNVDAANGIVMEGYLFKRASN 283

  Fly   324 KVRRVWQK------RRCRVTSDGFLDIFHADESKPPTRV--NLLTCQIKPVPDDKRG--FDLISY 378
            .. :.|.:      ||.....:..| ::.......||.|  :|..|.:|...|.:|.  |:::|.
  Rat   284 AF-KTWNRKKPDHIRRWFSIQNNQL-VYQKKFKDSPTVVVEDLRLCTVKHCEDIERRFCFEVVSP 346

  Fly   379 NRPYHFQAEDEGDQKAWMAVLVNCKEKALTKAF-------QHANPQMSPSLVELQ---------- 426
            .:....||:.|..::||    :...:.::..|:       :..:.:.|||...|.
  Rat   347 TKSCMLQADSEKLRQAW----IKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGSESKEKLL 407

  Fly   427 --KTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLT 489
              ::.::.||.:|||..|||||.. |..|.|:|.||.:||:|||:||.||||.|:::|||||...
  Rat   408 KGESALQRVQCIPGNTSCCDCGLA-DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWE 471

  Fly   490 TANLLIARAMGNSTLNDIMEAKLGR--GKLQHESSMEERYDFIRAKYVAKRYV------------ 540
            ...|.:...:||..:|.:.||||.:  .|.......:|:..:||||||.:::|
  Rat   472 PELLKLMCELGNDVINRVYEAKLEKMGVKKPQPGQRQEKEAYIRAKYVERKFVDKYSTLLSPSEQ 536

  Fly   541 ----------------------------------------------------------------- 540

  Rat   537 EKRIISKSCEDQRLSHTRVSVHTPVAAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIKSNDS 601

  Fly   541 -MRTCSDD-----------NDL---------------------RCDLEQAVVNADMSQLLQVWAE 572
             ::.||||           |.|                     ...|.:|....::.::.:..|.
  Rat   602 GIQQCSDDGRESLPSTVSANSLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAH 666

  Fly   573 GADLTCCLPSSDAGE-TALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTAL 636
            |||:...  :||..: |.|..|||   |.:|...:||:||    |.|     ....||.|:....
  Rat   667 GADVNWA--NSDENQATPLIQAVL---GGSLVTCEFLLQN----GAN-----VNQRDVQGRGPLH 717

  Fly   637 HLCAL-HDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINT 700
            |...| |..:.|  |.|:.||:....:.:.|..|.||.|..:.....|:..|...|:
  Rat   718 HATVLGHTGQVC--LFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEE-------- 772

  Fly   701 DWNLPNEDGSTDFSDDETVID 721
               :...:|......|||..|
  Rat   773 ---MRESEGLYGQPGDETYQD 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	45/221 (20%)
		PH_ASAP	302..410	CDD:270071	24/117 (21%)
		ArfGap_ASAP	425..541	CDD:350063	51/207 (25%)
		Ank_2	554..662	CDD:403870	32/109 (29%)
		ANK repeat	586..622	CDD:293786	13/36 (36%)
		ANK repeat	624..662	CDD:293786	11/38 (29%)
		Ank_2	636..>693	CDD:403870	16/57 (28%)
		SH3_ASAP	1095..1149	CDD:212755
Acap2	XP_017453554.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820