DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and asap2a

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_021322892.1	Gene:	asap2a / 570669	ZFINID:	ZDB-GENE-041210-256	Length:	1003	Species:	Danio rerio

Alignment Length:	1190	Identity:	469/1190 - (39%)
Similarity:	636/1190 - (53%)	Gaps:	225/1190 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..|.|:|||.||..||.|||.|.|.:||..||:|:..|||.|:.||..|.|:||:||||:.||.
Zfish     2 PDQITVAEFVTETNEDYKSPTASNFTTRMTHCRNTVSALEEALDVDRSVLYKMKKSVKAIYASGL 66

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            .||:||....:|||:.|...:.:|:||:|:|||||||.||||:||.|.|.||:|||:.||:||:|
Zfish    67 AHVENEEQYTQALEKFGENCVYRDDPDLGSAFLKFSVFTKELTALFKNLFQNMNNIITFPLDSLL 131

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFI---------KIEKEKKAQAKEAGMVRTEIDAAVVAEEM 188
            |.:|:|||||:|:|||||.||||.|..         |||||||..|::.||:||||..|.:||||
Zfish   132 KGDLKGVKGDLKKPFDKAWKDYETKVCKGHSLLKGSKIEKEKKEHARQHGMIRTEISGAEIAEEM 196

  Fly   189 EKERRLYQLQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKL 253
            |||||.:|||.||||||..:||.|.|::|||:||:|:||..|:|:|||:.:::....|..|:..|
Zfish   197 EKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVDNLKPSIEKLATDL 261

  Fly   254 HEIKQKQDEDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLL 318
            |.|||.|||:||.|..||.||::....|:.::...|:.|. .|.|||||.||:|.||..|.|:|.
Zfish   262 HSIKQVQDEERRQLTQLRDVLKTALQVEQKESRRDSQVRQ-SATYSLHQPQGNKEHGTERSGNLY 325

  Fly   319 KKSEGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYH 383
            |||:| :|:|||||:|.| .:|:|.|.|...::||.::||||||:|..|::|:.|||||::|.||
Zfish   326 KKSDG-LRKVWQKRKCTV-KNGYLTISHGTANRPPAKLNLLTCQVKHNPEEKKSFDLISHDRTYH 388

  Fly   384 FQAEDEGDQKAWMAVLVNCKEKALTKAF---QHANPQMSPSLV-ELQKTVIRYVQLLPGNDRCCD 444
            ||||||.:.:.|::||.|.||:||..||   ||....   ::| ||.|.::..|:.:.|||.|||
Zfish   389 FQAEDEPECQIWISVLQNSKEEALNNAFKGDQHVGEN---NIVQELTKAILGEVKRMAGNDVCCD 450

  Fly   445 CGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIME 509
            ||:... ||:|.|.|||.||:|||:||:||||:|||||||||.|:|:.||:|:.:||:..|:|||
Zfish   451 CGAPGP-TWLSTNLGILTCIECSGIHRELGVHYSRIQSLTLDVLSTSELLLAKNVGNAGFNEIME 514

  Fly   510 AKLGRG---KLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWA 571
            |.|...   |....|.|:.|.|||.|||..||:..:.|.|.......|..||...|:..|:||:|
Zfish   515 ACLTAEDVIKPNPASDMQARKDFIMAKYTEKRFARKKCPDALSKLHTLCDAVKARDIFSLIQVYA 579

  Fly   572 EGADLTCCLP---SSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKN 633
            ||.||...:|   ..:.|||||||||.....::|||:|||.||  ...|:|.|...        :
Zfish   580 EGVDLMEPIPLANGHEQGETALHLAVRLVDRTSLHIIDFLTQN--SLNLDKQTAKG--------S 634

  Fly   634 TALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHI 698
            ||||.|.|.|..||:|||||..|..::.|...:|.||||:.:.|..|.||:..|:..:.:|..|:
Zfish   635 TALHYCCLTDNSECLKLLLRGKASIDIANEAGETPLDIARRLKHLQCEELLNQALAGKFNAHVHV 699

  Fly   699 NTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIAN---- 759
            ..:|.|.:||  .|.||::  :||:.|..|      .|...:...:...:|:|.|.:.::.
Zfish   700 EYEWRLQHED--LDESDED--LDEKSSPHR------RDERPISCYTPGSNSLQLSPASLSRDGRD 754

  Fly   760 -CPSRQFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARN 823
             ...:|..:|:.:.:.|:                |:..|.         |||.|.||.:......
Zfish   755 LVKDKQRFVPNLVNNETY----------------GTIINT---------SSPVSLSSSAPPLPPR 794

  Fly   824 SLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTL---GSASSSSFYGTLPHPPRHSQNF 885
            :|...|.|.|...|                 :|...||:|   |...|||....: |||
Zfish   795 NLVQPSALAGLTQG-----------------SPGWKPGSLDLSGRQRSSSDPPNM-HPP------ 835

  Fly   886 DASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFG 950
                                 .|.||..                        |.:.|||
Zfish   836 ---------------------APPLRVT------------------------STSLLMP------ 849

  Fly   951 HKRSPSGESLNRNIHLAGAKLVLPP----TGELPTLKHVDKSALTRPKIPPPGPPSEREISNGQS 1011
                            :||   .||    ||.:.|:.       .:|| |..|||       ||:
Zfish   850 ----------------SGA---APPLAKATGMMETMN-------MQPK-PGQGPP-------GQN 880

  Fly  1012 NESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESNVSSSDNDRLNSS--PD 1074
            ....:|.|:              ||    |..|.|.|  |.::....     ...:.:||.  |.
Zfish   881 INRATSADK--------------NF----SKSTLMRS--GSIERPGR-----CQRNHVNSKEVPG 920

  Fly  1075 NPSKTGGAGLGG----KFHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGII 1135
            .|..|.|..|..    :..|...:|.:|:|:|||||.|||.|.|||:::|..|  :|:.|..|.|
Zfish   921 GPQNTTGQTLPATHMPRKTYLKPKRVKAMYNCVADNPDELTFSEGELIVVDGE--EDQEWWLGHI 983

  Fly  1136 EGQPTRKGMFPVSFVHMLPD 1155
            ||:|.|:|.|||:||..:.|
Zfish   984 EGEPMRRGAFPVTFVQFIMD 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	124/222 (56%)
		PH_ASAP	302..410	CDD:270071	58/107 (54%)
		ArfGap_ASAP	425..541	CDD:350063	63/118 (53%)
		Ank_2	554..662	CDD:403870	48/110 (44%)
		ANK repeat	586..622	CDD:293786	19/35 (54%)
		ANK repeat	624..662	CDD:293786	15/37 (41%)
		Ank_2	636..>693	CDD:403870	24/56 (43%)
		SH3_ASAP	1095..1149	CDD:212755	29/53 (55%)
asap2a	XP_021322892.1	BAR_ASAP2	34..257	CDD:153326	124/222 (56%)
		PH_ASAP	309..415	CDD:270071	58/107 (54%)
		ArfGap	433..550	CDD:307528	62/117 (53%)
		ANK repeat	562..594	CDD:293786	13/31 (42%)
		ANK	<597..685	CDD:238125	44/97 (45%)
		ANK repeat	597..630	CDD:293786	19/34 (56%)
		ANK repeat	632..663	CDD:293786	15/38 (39%)
		SH3	945..1000	CDD:327375	31/56 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1637
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	767	1.000	Inparanoid score	I524
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm24323
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10447
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870