DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and acap2a

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005163306.1	Gene:	acap2a / 564814	ZFINID:	ZDB-GENE-081104-34	Length:	824	Species:	Danio rerio

Alignment Length:	854	Identity:	186/854 - (21%)
Similarity:	327/854 - (38%)	Gaps:	251/854 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTHVD-NEMFM 76
            ||...|  ||   .|.:.:.|.....|.||.:|:       ||.|....:.::|..:.. |:.|:
Zfish     8 EECLKD--SP---RFRATIEDVEEDFGELESKLD-------KLVKLCIGMIDAGRVYNQANKQFV 60

  Fly    77 --VR--ALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELR 137
              :|  ||:....:|       ||::...||...:|::.....|.......:...:.:.:|.:||
Zfish    61 NGIRDLALQSTRDEV-------IGSSLAAFSETLQEMNNYHTILFDQAQRSIRSQLQTFVKEDLR 118

  Fly   138 GVKGDMKRPFDKAAKDYEAKFIK---IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQT 199
            ..| |.|:.|||.:::.|...:|   :.:.|..:.:||..:.|            ..::.::...
Zfish   119 KFK-DAKKQFDKVSEEKEVALVKNAQVPRNKLHEVEEATNILT------------TTQKFFRNIA 170

  Fly   200 CEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEI-----KQK 259
            .:|:|:...:::|..:|:|:.::.|.:|...:|..|..........:..||.:|.::     |:|
Zfish   171 LDYVLQINVLQSKRRLEILKSMLAYMNANLTFFNQGHDLFSQLQPLMKQLSGQLDQLVVDSAKEK 235

  Fly   260 QD-EDRRSLLDLRTVLR--STPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKS 321
            :| |.:.|.:..:..|:  ||.|.:...|:                   |..:|:..:|:|.|::
Zfish   236 RDMEQKHSSIQQKAALQDFSTEDSKLEYNI-------------------DTDNGIAMEGYLFKRA 281

  Fly   322 EGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRV--NLLTCQIKPVPDDKRG--FDLISYNRPY 382
            .... :.|.:|...:.:...  ::.......||.|  :|..|.:|...|.:|.  |:::|.::..
Zfish   282 SNAF-KTWNRRWFSIQNSQL--VYQKRFRDNPTVVVEDLRLCTVKHCEDVERRFCFEVLSPSKSC 343

  Fly   383 HFQAEDEGDQKAWMAVLVNCKEKALTKAFQH-------ANPQMSPSL---------VELQK--TV 429
            ..||:.|..::||    :...:.::..|::.       .:.|.|.||         |:|.|  :.
Zfish   344 MMQADSEKLRQAW----IKAVQSSIASAYRENEDEIISLDRQSSASLGSLDSGCESVKLVKGESA 404

  Fly   430 IRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLL 494
            ::.|..:|||:.||||| ::|..|.|:|..|.:||:|||:||.||||:|:::|||||......|.
Zfish   405 LQRVLAIPGNEFCCDCG-QSDPRWASINLCITLCIECSGIHRSLGVHNSKVRSLTLDTWEPELLK 468

  Fly   495 IARAMGNSTLNDIMEA---KLGRGKLQHESSMEERYDFIRAKYVAKRYVMRT------------- 543
            :...:||..:|.|.||   :.|..|.|......|...|||||||.||:|::.
Zfish   469 LMCELGNDVINQIYEAHREENGGKKPQPGDPRREIEAFIRAKYVDKRFVLKPTEQEQMEKIMTLR 533

  Fly   544 ----------------------------------------------CSDDND------------- 549
                                                          |.|:.|
Zfish   534 KHDKRMQGNMEFLPPRPPPPTPKLRTASNASVASLSGQEVRRDSLFCPDELDSLFSYFDTSSKLQ 598

  Fly   550 -----------------------------LRCDLEQAVVNADMSQ-------------------- 565
                                         ...||.::...|:.::
Zfish   599 NLKRADSGIQNSADGSREMLASTPSSSSLSETDLPESEAAANQAERSPVFSKLTNFSADSLLYWA 663

  Fly   566 --------LLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATN 622
                    :.|..|.|||:. .:...|:..|.|..||   .|.:|...:||:||
Zfish   664 SCACSLKDMAQALAHGADIN-WVNLEDSSRTPLIQAV---QGGSLISCEFLLQN----------- 713

  Fly   623 PAGLL---DVTGKNTALHLCAL-HDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCREL 683
             |..:   |:.|:....|...| |..:.|  |.|:.||.....::.:::.|.||.|..:.....|
Zfish   714 -AACVDQQDIRGRGPLHHATILGHTGQVC--LFLKRGAKQNTVDTDSRSPLSIAVEAANADIVTL 775

  Fly   684 IECAIKREK 692
            :..|...|:
Zfish   776 LRLAKMNEE 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	44/221 (20%)
		PH_ASAP	302..410	CDD:270071	22/111 (20%)
		ArfGap_ASAP	425..541	CDD:350063	53/120 (44%)
		Ank_2	554..662	CDD:403870	29/139 (21%)
		ANK repeat	586..622	CDD:293786	10/35 (29%)
		ANK repeat	624..662	CDD:293786	11/41 (27%)
		Ank_2	636..>693	CDD:403870	15/58 (26%)
		SH3_ASAP	1095..1149	CDD:212755
acap2a	XP_005163306.1	BAR_ACAP2	18..217	CDD:153322	45/225 (20%)
		PH_ACAP	273..369	CDD:270070	21/102 (21%)
		PH	273..365	CDD:278594	20/98 (20%)
		ArfGap	402..520	CDD:279720	52/118 (44%)
		ANK repeat	657..686	CDD:293786	5/29 (17%)
		ANK	658..776	CDD:238125	31/135 (23%)
		Ank_2	660..754	CDD:289560	27/111 (24%)
		ANK repeat	690..721	CDD:293786	11/45 (24%)
		ANK repeat	723..754	CDD:293786	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820