DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and unm_sa1614

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005169383.1	Gene:	unm_sa1614 / 561879	ZFINID:	ZDB-GENE-120411-1	Length:	1023	Species:	Danio rerio

Alignment Length:	1193	Identity:	426/1193 - (35%)
Similarity:	605/1193 - (50%)	Gaps:	211/1193 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..|:|.||:.||..||||||||:|.::|..||::...:||.|:.||..|.|:|||.||.|.||.
Zfish     2 PEFISVDEFIAETLEDYSSPTTSSFYTKMTSCRNSANNIEEALDSDRTILQKMKKAAKAKHISGQ 66

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            .|:.:....:.::|:|........|.::.:||.||:..:|||...||.|::::.:.|.|.:||::
Zfish    67 DHISHLESYINSMEKLAVNFRNNGEQEVASAFNKFAEFSKELLTPMKNLLKSMLHNVNFFLDSLV 131

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |.:|:.||||:|:|||||.:|||.||.||||||:..||:.||||||:....:|||||||||::||
Zfish   132 KGDLKEVKGDLKKPFDKAWRDYENKFTKIEKEKRELAKQYGMVRTEVSGGEIAEEMEKERRMFQL 196

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||:|..:||||.|::|||:||::||:..|:|::.|...|....||..|:.:|..||.||||
Zfish   197 QMCEYLIKVNEIKTKKGVDLLQNLIKHYHSQCNFFQECLAATEKLKQYIDALTGQLSAIKHKQDE 261

  Fly   263 DRRSLLDLRTVLRST--PDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKV 325
            ::|.|..||..||..  |:|:....   .:|.|....||:|||||:|.:|..:.|:|.|:|:| :
Zfish   262 EKRQLCSLRDQLRPALLPEFKEQSR---RDSLSRQTVYSMHQLQGNKQYGTEKSGYLYKRSDG-L 322

  Fly   326 RRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEG 390
            |::||||:|.| .:.:|.|.|...:|.|.::||||||:||..:||:.|||||:||.|||.|:||.
Zfish   323 RKMWQKRKCTV-QNCYLTIAHGTPNKSPAKLNLLTCQVKPSLEDKKCFDLISHNRTYHFLADDEC 386

  Fly   391 DQKAWMAVLVNCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWIS 455
            |..||::||.|.|::||..|.....|....|:.:|.:.:...::.:|||..|||||: :|.:|||
Zfish   387 DCVAWISVLTNSKQEALNVALDERRPSGENSVEDLTRAITEDIRRMPGNSVCCDCGA-SDPSWIS 450

  Fly   456 LNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLG--RGKLQ 518
            :|.|||.||:|||:||::|||:||||||:||.|.|:.||:||.:||...|:|.||.|.  ..|..
Zfish   451 INLGILTCIECSGIHREMGVHYSRIQSLSLDKLGTSELLLARNVGNLGFNEIAEANLPSVSVKPS 515

  Fly   519 HESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPS- 582
            .||.|..|.|||.:||:..::..|:.......|..|:.||.:.|:..|||::.|..|.:..||.
Zfish   516 AESDMAVRKDFILSKYMEWQFAQRSGGSLETKRKYLQDAVRSRDVFSLLQLYTERTDFSLSLPCP 580

  Fly   583 -SDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDV-TGK-NTALHLCALHDR 644
             .:.||||||||||....::||:.|||..|            ...||| |.| |||||.|..|::
Zfish   581 LQEKGETALHLAVLLADRTSLHVADFLFHN------------CNNLDVQTMKGNTALHYCCQHNK 633

  Fly   645 RECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNED- 708
            .||:|||||:.|:..:||...:|.||:|:.:.|:.|.|||..:...:.:...|:..||.|..:|
Zfish   634 TECLKLLLRAKANTHIKNDNGETGLDVARRLKHSLCEELIHQSQNDQFNMHVHVEYDWRLRQDDL 698

  Fly   709 -GSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSGLP 772
             .|.|..:|:|                  .||.:.|.....|:..|||.
Zfish   699 YESDDDLEDKT------------------GPVKKERLGRPFSLYHSSSS---------------- 729

  Fly   773 SYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDLGGHVTG 837
              :|:.|.|                 ||.|..|.|...:.|...:.|....|.|.|
Zfish   730 --SHAGGGS-----------------GGGGLFNVGRRLALARGDNRREVYASPNSQ--------- 766

  Fly   838 ARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDIRAINHKNQSLDV 902
                  |.:::|     .|.|||.:...          |.|||         :||.|
Zfish   767 ------TRSLDS-----PPPPPPSSPAP----------PLPPR---------VRAPN-------- 793

  Fly   903 AYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLA 967
                :|......|||.....:....|:                      ||:|.
Zfish   794 ----VPPPPPPMSSPDDWTSHEVKSSK----------------------KRTPP----------- 821

  Fly   968 GAKLVLPPTGELPTLKHVDKSALTRPKIPPPGPPSEREISNGQSNESISSMDE---GPVAP---- 1025
                  ||.    .::|  |...:.|.  |..|||......|.::..:.:...   ||.:|
Zfish   822 ------PPL----IIRH--KRTYSEPS--PQVPPSPHSTRQGPADYGVPTGPRSFGGPDSPFQKC 872

  Fly  1026 -------PRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESNVSSSDNDRLNSSPDNPS----KT 1079
                   |...:|..:..|:...:..|.:|......:.....:.|:.......||.:|.    :.
Zfish   873 VSGSPKYPTSTLNSLSELPERAGFRADGESGSSHFLYQTPQPMGSAGRHTPGLSPTSPRSFSLEA 937

  Fly  1080 GGAGLGGKFHYNGQ------------RRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWME 1132
            .|.......|....            ||.:|:||||||:.|||.|.||::|:||.|  ||.:|..
Zfish   938 NGGSSSSSCHSAPHPLPRKNLMKPKLRRVKAMYDCVADHHDELTFNEGDVLVVLGE--DDADWWH 1000

  Fly  1133 GIIEGQPTRKGMFPVSFVHMLPD 1155
            |.|||||.|.|:||.|||.||.:
Zfish  1001 GYIEGQPDRMGLFPASFVSMLAE 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	100/213 (47%)
		PH_ASAP	302..410	CDD:270071	55/107 (51%)
		ArfGap_ASAP	425..541	CDD:350063	58/117 (50%)
		Ank_2	554..662	CDD:403870	47/111 (42%)
		ANK repeat	586..622	CDD:293786	16/35 (46%)
		ANK repeat	624..662	CDD:293786	20/39 (51%)
		Ank_2	636..>693	CDD:403870	23/56 (41%)
		SH3_ASAP	1095..1149	CDD:212755	31/53 (58%)
unm_sa1614	XP_005169383.1	BAR_ASAPs	34..248	CDD:153288	100/213 (47%)
		PH_ASAP	300..406	CDD:270071	55/107 (51%)
		PH	309..395	CDD:278594	43/87 (49%)
		ArfGap	423..540	CDD:279720	57/117 (49%)
		Ank_2	551..651	CDD:289560	47/111 (42%)
		ANK repeat	551..582	CDD:293786	11/30 (37%)
		ANK repeat	584..618	CDD:293786	19/45 (42%)
		ANK	<585..673	CDD:238125	45/99 (45%)
		ANK repeat	620..651	CDD:293786	16/30 (53%)
		SH3_ASAP	965..1017	CDD:212755	31/53 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1637
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	767	1.000	Inparanoid score	I524
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24323
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	LDO	PTHR45854
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840