DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and asap2b

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001038398.2	Gene:	asap2b / 560581	ZFINID:	ZDB-GENE-030131-5060	Length:	1024	Species:	Danio rerio

Alignment Length:	1192	Identity:	459/1192 - (38%)
Similarity:	643/1192 - (53%)	Gaps:	208/1192 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..:.|:|||:.|..||.:||||.|.:||..||:|:..|||.|:.||..|.|:||:||||::||.
Zfish     2 PDQLTVTEFVDITHEDYKAPTTSVFCTRMAHCRNTVAALEEALDLDRSVLHKMKKSVKAINSSGQ 66

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            |||:||...::|:||.....:.:|:|::...||.|:..||||:||.|.|:||:|||:.||:||:|
Zfish    67 THVENEEQYIQAIERFTDNTVYKDDPEMSNYFLTFAGFTKELTALFKNLLQNMNNIITFPLDSLL 131

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |.:|:|||||:|:|||||.||||.|..||||||:..||:.|::||||....:||||||||||:||
Zfish   132 KGDLKGVKGDLKKPFDKAWKDYETKLSKIEKEKREHAKQHGLIRTEISGGEIAEEMEKERRLFQL 196

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||:|..:||.|.|::||.:||:|:||..|:|:|||:.:::...::..|:..|...||.||.
Zfish   197 QMCEYLIKVNEIKVKKGVDLLHNLIKYFHAQCNFFQDGLKVVDNLKPFMEKLATDLTANKQTQDA 261

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRR 327
            :|:.||.|:..|:|....|..::..|.::    ||||||||||:|.||..|.|.|||:||| :|:
Zfish   262 ERKQLLQLKETLKSALQSECKEDAQSKQN----AGYSLHQLQGNKAHGTERSGMLLKRSEG-LRK 321

  Fly   328 VWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGDQ 392
            |||||:|.| .:|.|.|.|...:.||..:||||||:|..||:|:.|||||::|.||||.|||.:.
Zfish   322 VWQKRKCSV-KNGLLTISHGTPNAPPANLNLLTCQVKRNPDEKKCFDLISHDRTYHFQTEDEAEC 385

  Fly   393 KAWMAVLVNCKEKALTKAFQHANPQMSPSLV-ELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISL 456
            :.|::||.|.||:||..||:....:...::| ||.|.::..|:.:.|||.|||||:.|. ||:|.
Zfish   386 QVWVSVLQNSKEEALNNAFKDDQNEGENNIVRELTKAIVGEVKKMSGNDVCCDCGASNP-TWLST 449

  Fly   457 NFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGR--GKLQH 519
            |.|:|:||:|||:||::|||:|||||||||.|.|:.||:|.::||:..|:||||||..  .|...
Zfish   450 NLGVLICIECSGIHREMGVHYSRIQSLTLDLLGTSELLLANSVGNAAFNEIMEAKLSSEIPKPNP 514

  Fly   520 ESSMEERYDFIRAKYVAKRYVMRTCSDDNDLR----CDLEQAVVNADMSQLLQVWAEGADL--TC 578
            .|.|:.|.|||.|||..||:..:..: ||..|    ||   ||.:.|:..|:||:|||.||  |.
Zfish   515 SSDMQVRKDFITAKYTEKRFAQKKYA-DNAARLHALCD---AVKSRDIFSLIQVYAEGLDLMETI 575

  Fly   579 CLPSS-DAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD-VTGK-NTALHLCA 640
            ..|:. :.|||:|||||.....::|||||||:||            :|.|| .|.| :||||.|.
Zfish   576 NQPNQHEPGETSLHLAVRMVDRNSLHIVDFLVQN------------SGNLDKQTAKGSTALHYCC 628

  Fly   641 LHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLP 705
            |.|..||||||||..|...:.|...:||||:|:.:.|:.|.||:..|...:.:...|:..||.|.
Zfish   629 LTDNSECMKLLLRGKASVSITNDAGETALDLAQRLKHSKCEELLTQAQTGKFNVHVHVEYDWRLH 693

  Fly   706 NEDGSTDFSDDETVIDER----KSRSRPPS-FAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQF 765
            |||  .|.|:||  ::::    :...||.| ...|..|::.:.|:....:.:    :.|...|.|
Zfish   694 NED--LDESEDE--MEDKPIPIRREERPISCIVPGSGPMMPNMSALARDVAN----VVNNKQRAF 750

  Fly   766 TLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNG-PG---------NGGSSPSSASSQSVRA 820
             :||.:.:.|:.....|           ::..:|..| ||         ..|.||...:....|:
Zfish   751 -IPSMMMNETYGTMLDP-----------NSPPLGLPGVPGIPLLPPRPLGRGWSPPMENIGRQRS 803

  Fly   821 ARNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNF 885
            ..:..|.|               |...|:......|||||......         |.||
Zfish   804 CSDPANPQ---------------TPEQNNSVYVLPPAPPPPPAPKR---------PPPP------ 838

  Fly   886 DASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFG 950
                                                        ||..|      .|.||.|.
Zfish   839 --------------------------------------------DPKAS------LLPPAATA-- 851

  Fly   951 HKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRPKIP----PPGPPSEREISN--- 1008
             ..:||...|.....|..|.:| ||...:||      |...:|..|    ||..|:.:.:.:
Zfish   852 -PPAPSAPLLIPPAPLRPAPIV-PPAPVMPT------SFSYKPPPPPVPVPPKAPASKPVKSPTR 908

  Fly  1009 ---GQSNESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESN--VSSSDNDR 1068
               |..::.:|.....|:.|      ||:            |.:...|..||::.  |.:.:...
Zfish   909 DAIGSFSKVVSVNKAPPIGP------QSS------------DKTDAPLSASAQATAPVPAPEPKP 955

  Fly  1069 LNSSPDNPSKTGGAGLGGKFHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEG 1133
            ..:.|....|                |.:|||:|||||.|||.|.|||::||..|  :|:.|..|
Zfish   956 RTAPPKQRPK----------------RVKALYNCVADNADELTFSEGEMIIVDGE--EDKEWWVG 1002

  Fly  1134 IIEGQPTRKGMFPVSFVHMLPD 1155
            .|:|:|||:|:|||:|||.:.|
Zfish  1003 HIDGEPTRRGVFPVAFVHFVTD 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	114/213 (54%)
		PH_ASAP	302..410	CDD:270071	60/107 (56%)
		ArfGap_ASAP	425..541	CDD:350063	63/117 (54%)
		Ank_2	554..662	CDD:403870	51/112 (46%)
		ANK repeat	586..622	CDD:293786	17/35 (49%)
		ANK repeat	624..662	CDD:293786	21/39 (54%)
		Ank_2	636..>693	CDD:403870	25/56 (45%)
		SH3_ASAP	1095..1149	CDD:212755	31/53 (58%)
asap2b	NP_001038398.2	BAR	34..248	CDD:299863	114/213 (54%)
		PH_ASAP	297..403	CDD:270071	60/107 (56%)
		PH	306..393	CDD:278594	47/88 (53%)
		ArfGap	421..537	CDD:279720	62/116 (53%)
		ANK repeat	548..579	CDD:293786	14/33 (42%)
		ANK	<575..672	CDD:238125	48/108 (44%)
		Ank_5	<584..626	CDD:290568	25/53 (47%)
		ANK repeat	584..617	CDD:293786	20/44 (45%)
		Ank_5	606..660	CDD:290568	29/65 (45%)
		ANK repeat	619..650	CDD:293786	17/30 (57%)
		SH3_ASAP2	966..1021	CDD:212899	33/56 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1637
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	767	1.000	Inparanoid score	I524
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm24323
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840