DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and ADAP2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_024306599.1	Gene:	ADAP2 / 55803	HGNCID:	16487	Length:	403	Species:	Homo sapiens

Alignment Length:	134	Identity:	37/134 - (27%)
Similarity:	56/134 - (41%)	Gaps:	44/134 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 RYVQLL----PGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHR---DLGVHHSRIQSLTLDNL 488
            |.::||    .||..|.|||:. |..|.|...||.:|:.|.||||   |:    ||::|:.||..
Human    10 RLLELLRAPDTGNAHCADCGAA-DPDWASYKLGIFICLNCCGVHRNFPDI----SRVKSVRLDFW 69

  Fly   489 TTANLLIARAMGNSTLNDIMEAKLGRGKLQHESSMEERY-----------------DFIRAKYVA 536
            .               :.|:|..:..|.|:.::..|.|.                 .:|||||..
Human    70 D---------------DSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYER 119

  Fly   537 KRYV 540
            :.::
Human   120 REFM 123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	37/134 (28%)
		Ank_2	554..662	CDD:403870
		ANK repeat	586..622	CDD:293786
		ANK repeat	624..662	CDD:293786
		Ank_2	636..>693	CDD:403870
		SH3_ASAP	1095..1149	CDD:212755
ADAP2	XP_024306599.1	ArfGap	8..126	CDD:307528	37/134 (28%)
		PH1_ADAP	133..241	CDD:270072
		PH2_ADAP	255..362	CDD:241282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900