DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and ARFGAP1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_011527203.1	Gene:	ARFGAP1 / 55738	HGNCID:	15852	Length:	416	Species:	Homo sapiens

Alignment Length:	492	Identity:	103/492 - (20%)
Similarity:	169/492 - (34%)	Gaps:	151/492 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 KTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTA 491
            :.|::.|::...|:.|.:||:.|. .|:|:.:||.:|::|||.||.||||.|.::|:|:|.....
Human     7 RKVLKEVRVQDENNVCFECGAFNP-QWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDI 70

  Fly   492 NLLIARAMGNSTLNDIMEAKLGRGKLQHES----SMEERYD-----FIRAKYVAKRYVMRTCSDD 547
            .|...:|.||:...:.:|:       |.:.    |::|:|:     ..|.|.||       .::.
Human    71 ELEKMKAGGNAKFREFLES-------QEDYDPCWSLQEKYNSRAAALFRDKVVA-------LAEG 121

  Fly   548 NDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPS------------SDAGETALHLAVLREMGS 600
            .:...:...|          |.|......|  |||            :.:.:.|....:..::||
Human   122 REWSLESSPA----------QNWTPPQPRT--LPSMVHRVSGQPQSVTASSDKAFEDWLNDDLGS 174

  Fly   601 TL-----HIVDFLIQNMPP-----------------KGLNKATNPAGLLDVTGKNTALHLCALHD 643
            ..     ..|.|  .|.||                 .|.:..|..|.......|..|
Human   175 YQGAQGNRYVGF--GNTPPPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGA-------- 229

  Fly   644 RRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSA--FDHINTDWNLPN 706
                    .:.|:....|...:|...:.|.|:||:....:::.|.::.|..  ||.:::
Human   230 --------TKFGSQASQKFWGHKQQPEPASELGHSLNENVLKPAQEKVKEGKIFDDVSS------ 280

  Fly   707 EDGSTDFSDDETVIDERKSRSRPPSFAG-GDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSG 770
              |.:..:.....:..:..|.....|:| .:.|:        ||
Human   281 --GVSQLASKVQGVGSKGWRDVTTFFSGKAEGPL--------DS--------------------- 314

  Fly   771 LPSYTHSAGTSPKQHI-------SVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQ 828
             ||..||...|...|.       |..:..|||.      |.....||   ||.|...|..|...:
Human   315 -PSEGHSYQNSGLDHFQNSNIDQSFWETFGSAE------PTKTRKSP---SSDSWTCADTSTERR 369

  Fly   829 SDLGGHVTGARKSTSTANMN------SLKKRTAPAPP 859
            |.....|.|:..:...:|.:      ..||...||.|
Human   370 SSDSWEVWGSASTNRNSNSDGGEGGEGTKKAVPPAVP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	38/122 (31%)
		Ank_2	554..662	CDD:403870	21/141 (15%)
		ANK repeat	586..622	CDD:293786	9/57 (16%)
		ANK repeat	624..662	CDD:293786	4/37 (11%)
		Ank_2	636..>693	CDD:403870	8/56 (14%)
		SH3_ASAP	1095..1149	CDD:212755
ARFGAP1	XP_011527203.1	ArfGap	7..114	CDD:279720	35/114 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810