Protein Alignment Asap and ASAP3

DIOPT Version :10

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_011540057.1
• Gene: ASAP3 / 55616
• HGNCID: 14987
• Length: 926
• Species: Homo sapiens
• Alignment Length: 992
• Identity: 365/992 - (36%)
• Similarity: 523/992 - (52%)
• Gaps: 124/992 - (12%)

  Fly     3 PSLIAVSEFVEETRSDYSSPT-TSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSG 66
            |...:|:||:..|..|.|||. .:.||::||..|......||.||.|:..|.::||||:|||:||
Human     2 PEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVRAIHSSG 66

  Fly    67 NTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSM 131
            ..||:||.....|:|.||...:.|:..::...||..:|.|:|::||.|.|:||:||||.||:||:
Human    67 LGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSL 131

  Fly   132 LKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQ 196
            :|.:||..:.|.|:..:||.||||||..|:|||:. :|:..|.:..|     ||::|::|||::|
Human   132 MKGQLRDGRQDSKKQLEKAWKDYEAKMAKLEKERD-RARVTGGIPGE-----VAQDMQRERRIFQ 190

  Fly   197 LQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQD 261
            |..||||||..:.:.|.|.:.||.||:::||..|:|:||.:..:....:|..|:..:|.:.|.|:
Human   191 LHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQE 255

  Fly   262 EDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVR 326
            ::.:.|..||..||.|...|..:.......::.|.|||:||.||:|..|..:.|.|.|||:| :|
Human   256 DELQKLTQLRDSLRGTLQLESREGQEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDG-IR 319

  Fly   327 RVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGD 391
            ||||||:|.| ..|.|.|.|:..::||.::.|||||::|.|::|:.|||:::||.||||||||.:
Human   320 RVWQKRKCGV-KYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHE 383

  Fly   392 QKAWMAVLVNCKEKALTKAFQHANPQMSPSL----------VELQKTVIRYVQLLPGNDRCCDCG 446
            .:||::||.|.|::||:.||. ..|...|..          .:|.|.:|..|:..|||.:|||||
Human   384 CEAWVSVLQNSKDEALSSAFL-GEPSAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDCG 447

  Fly   447 SRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAK 511
            :. |.||:|.|.|:|.|||||||||:|||..||:||||||.|..:.||:|..|||::.|::|||:
Human   448 AA-DPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQ 511

  Fly   512 L---GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEG 573
            |   |..|...||.|..|.|:|.||||..|:. |.|:.:..   .|..|:.|.|:..:|:.:|.|
Human   512 LPSHGGPKPSAESDMGTRRDYIMAKYVEHRFA-RRCTPEPQ---RLWTAICNRDLLSVLEAFANG 572

  Fly   574 ADLTCCLPSSDA---GETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGK--N 633
            .|....||..||   .|..|||||.....::|.:|||:|||            .|.||....  |
Human   573 QDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQN------------GGHLDAKAADGN 625

  Fly   634 TALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFD-H 697
            ||||..||:::.:|:||||:..|.....|...:||||||::..|..|.||:|.| :....||. |
Human   626 TALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQA-QAGTFAFPLH 689

  Fly   698 INTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPS 762
            ::..|.:..|.|| |..:||   :|:...|..|..:|....  |:|..            ..|..
Human   690 VDYSWVISTEPGS-DSEEDE---EEKVGPSPVPQASGWQKE--RARLG------------LRCLL 736

  Fly   763 RQFTLPSGLPSYTHSAG----TSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARN 823
            :       ||:..|.|.    .|.|.:.:|.. ||:||..|          .|......:....:
Human   737 K-------LPAQAHWASGRLDISNKTYETVAS-LGAATPQG----------ESEDCPPPLPVKNS 783

  Fly   824 SLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAP-PPGTLGS-ASSSSFYGTL-PHPPRHSQNF 885
            |..:......|.:|.|...|:.        ::.|| .|.:||| |||||....| |..|..:...
Human   784 SRTLVQGCARHASGDRSEVSSL--------SSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPN 840

  Fly   886 DASDIRAINHKNQSLDVAYGTLPH-----LRSVESSPRGGGGYGYGV-SQDPGGS---------- 934
            ....:|.....::. .:..||.|.     :|....|.|   .|..|. |.:.|.|
Human   841 SEEGLREPPGTSRP-SLTSGTTPSEMYLPVRFSSESTR---SYRRGARSPEDGPSARQPLPRRNV 901

  Fly   935 ------GNGSNNSLMPA 945
                  |:||....:||
Human   902 PVGITEGDGSRTGSLPA 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	91/213 (43%)
		PH_ASAP	302..410	CDD:270071	55/107 (51%)
		ArfGap_ASAP	425..541	CDD:350063	64/118 (54%)
		ANKYR	<573..709	CDD:440430	53/141 (38%)
		ANK repeat	586..622	CDD:293786	13/35 (37%)
		ANK repeat	624..662	CDD:293786	16/39 (41%)
		Vac17	<706..>788	CDD:435863	19/85 (22%)
		SH3_ASAP	1095..1149	CDD:212755
ASAP3	XP_011540057.1	BAR_ASAP3	35..243	CDD:153324	91/213 (43%)
		PH_ASAP	296..402	CDD:270071	55/107 (51%)
		ArfGap_ASAP3	426..548	CDD:350087	66/123 (54%)
		ANK repeat	553..586	CDD:293786	12/32 (38%)
		ANK repeat	588..621	CDD:293786	16/44 (36%)
		ANKYR	<592..681	CDD:440430	41/101 (41%)
		ANK repeat	623..654	CDD:293786	13/30 (43%)
		Metaviral_G	743..878	CDD:462833	37/157 (24%)