DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Asap and APPL2

DIOPT Version :9

Sequence 1:NP_001014504.1 Gene:Asap / 35783 FlyBaseID:FBgn0050372 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001238833.1 Gene:APPL2 / 55198 HGNCID:18242 Length:670 Species:Homo sapiens


Alignment Length:470 Identity:95/470 - (20%)
Similarity:189/470 - (40%) Gaps:116/470 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 PDCRHTIGVLEERLEFDREGLT----KLKKAVKAIHNSGNTHVDNEMFMVRALERLGGKVIEQD- 91
            |..|..:.|.||    |...||    :|.:|::.::.:     .|||.:  |.::|..:::..: 
Human    17 PQTRSLLSVFEE----DAGTLTDYTNQLLQAMQRVYGA-----QNEMCL--ATQQLSKQLLAYEK 70

  Fly    92 --------EPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFD 148
                    :.::.:....||.|..||:.|...|.:.:.:.::.|:....:.:|..| ..:|..|.
Human    71 QNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEV-STLKDLFG 134

  Fly   149 KAAKDY---------EAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLL 204
            .|:.|.         .||:.::.|:     ||...|:||     |.:|:...||...|.:.:|..
Human   135 LASNDVCLFLEHDLSMAKYSRLPKK-----KENEKVKTE-----VGKEVAAARRKQHLSSLQYYC 189

  Fly   205 KYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQ----TIEHFGTYIGDLSEKLH-EIKQKQDEDR 264
            ....::.:..:.:::.:|.:.|...|:||.|.:    .::.|.:.:.|:.:.:. |::.:.::.|
Human   190 ALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMR 254

  Fly   265 RSLLDLRTVLRS--TPDFERVDNVPSSESRSGGAGY-SLHQLQG------DKHHGVTRQGHLLKK 320
            .|..:|.:|..|  |||.: |.....:.:....||| :|....|      ::.:..|:.|:|:.:
Human   255 VSQQELLSVDESVYTPDSD-VAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQ 318

  Fly   321 SEGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPV-------------PDDKRG 372
            ..|.|            :.|.:.             :|..|.:..|             |:.|.|
Human   319 PRGAV------------AGGLIQ-------------DLDNCSVMAVDCEDRRYCFQITTPNGKSG 358

  Fly   373 FDLISYNRPYHFQAEDEGDQKAWMAVLVNCKEKA-LTKAFQHANPQMSPSLVELQKTVIRYVQLL 436
            ..|         |||...:.:.|:..:.|...:. ||.     ||:  ...::|.:|.::.|..:
Human   359 IIL---------QAESRKENEEWICAINNISRQIYLTD-----NPE--AVAIKLNQTALQAVTPI 407

  Fly   437 P--GNDRCCDCGSRN 449
            .  |..:...|.|:|
Human   408 TSFGKKQESSCPSQN 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsapNP_001014504.1 BAR_ASAPs 35..249 CDD:153288 49/239 (21%)
PH_ASAP 302..410 CDD:270071 21/127 (17%)
ArfGap_ASAP 425..541 CDD:350063 7/27 (26%)
Ank_2 554..662 CDD:403870
ANK repeat 586..622 CDD:293786
ANK repeat 624..662 CDD:293786
Ank_2 636..>693 CDD:403870
SH3_ASAP 1095..1149 CDD:212755
APPL2NP_001238833.1 BAR_APPL2 20..240 CDD:153316 50/241 (21%)
BAR-PH_APPL 258..382 CDD:270067 30/158 (19%)
PTB_APPL 488..621 CDD:269980
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..670
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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