Protein Alignment Asap and CenB1A

DIOPT Version :10

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Alignment Length: 933
• Identity: 212/933 - (22%)
• Similarity: 338/933 - (36%)
• Gaps: 298/933 - (31%)

  Fly     7 AVSEFVEETRSDYSSPTTSTFASR-MPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTHV 70
            |..|| ||...|  ||....|.|: ..|..|    ||:|||       |:.|......:||..:|
  Fly     3 ATIEF-EECLKD--SPRFRQFVSKEESDIEH----LEQRLE-------KIIKLCNVAVDSGKEYV 53

  Fly    71 DNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSE 135
            .|:.....:|..|....:  |..:...|..|.....:|::.....|:...:..|:..:...:|.:
  Fly    54 KNQSAFAMSLWDLQQHFL--DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDD 116

  Fly   136 LRGVKGDMKRPFDKAAKDYEAKFIK---IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            :..|| |.|..|.|.::.|:...||   ..|.:..:.:||            |..:...:..:|.
  Fly   117 INQVK-DYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEA------------ANILSASKSCFQH 168

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            ...:|:......:.:....:|..|::||.|...|:..|......|..:..::||.|:.::
  Fly   169 TALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALR----- 228

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTR-------------Q 314
                           .|:::                 |.:...::|..|.|             :
  Fly   229 ---------------GDYQQ-----------------LEKAMQNRHMSVNRYCDSNTNSTSNKIE 261

  Fly   315 GHLLKKSEGKVRRVWQKR-----------RCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPD 368
            |:|.|| :.|..:.|.:|           |.|...|.| .:...|         |..|.::||.:
  Fly   262 GYLFKK-KSKGFKTWCRRWFYLSDNQLVYRKRSNEDSF-SVMEED---------LRICSVRPVNE 315

  Fly   369 DKRG--FDLISYNRPYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQ-----HANPQM--SPSLVE 424
            ..|.  |::||..:.:..||:.......|::.|    :.::..|.|     |:.||.  :|:...
  Fly   316 GDRRFCFEVISPTKSHILQADSADMLSLWISAL----QHSIGAAIQHDSTHHSRPQSTNAPNNSL 376

  Fly   425 LQKTVIRYVQLL--PGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDN 487
            ..|..|.:.:.|  |||..||||.| .:..|.|:|.||.:||:||||||.||||:|:::|||||.
  Fly   377 PAKRRIHWEEFLKIPGNAYCCDCRS-PEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDA 440

  Fly   488 LTTANLLIARAMGNSTLNDIMEAKLGRG----KLQHESSMEERYDFIRAKYVAKRYVM------- 541
            ..:.|:.:...:||..:|.|.||::|..    |...:..:..|..:|:||||.:|:|.
  Fly   441 WESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQE 505

  Fly   542 ---------------------------------------------------------RTCSDD-- 547
                                                                     :|.|||
  Fly   506 LLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPS 570

  Fly   548 --------NDLRCDLEQAVVN-------------------------------------------- 560
                    ::|..|.:...:|
  Fly   571 IYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDA 635

  Fly   561 ----------ADMSQLL-------------QVWAEGADLTCCLPSSDAGETALHLAVLREMGSTL 602
                      .|.:|||             ..:|.|||.....| .|...:.||.||:  .||.:
  Fly   636 ESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNP-QDRQRSFLHQAVI--SGSVM 697

  Fly   603 HIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKT 667
             ..:||:       ||.|...|  :|..| .:|||:.........:.|||:..|.|:|.:|..|.
  Fly   698 -ACEFLL-------LNGAAIDA--VDEMG-YSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKK 751

  Fly   668 ALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSF 732
            |||||.:..:.....|:     |.....|.|.     ||::.:   .:|||..:..|..|:.|:
  Fly   752 ALDIAVDQENADIVTLL-----RLTQLNDEIG-----PNDEYN---GEDETYKNVMKDFSKLPA- 802

  Fly   733 AGGDSPVLRSR--SSTCDSIQSS 753
              ..:.|||.|  |:|.:|.:||
  Fly   803 --SQTRVLRQRHDSNTLESQRSS 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	44/216 (20%)
		PH_ASAP	302..410	CDD:270071	27/133 (20%)
		ArfGap_ASAP	425..541	CDD:350063	50/121 (41%)
		ANKYR	<573..709	CDD:440430	41/135 (30%)
		ANK repeat	586..622	CDD:293786	11/35 (31%)
		ANK repeat	624..662	CDD:293786	12/37 (32%)
		Vac17	<706..>788	CDD:435863	16/50 (32%)
		SH3_ASAP	1095..1149	CDD:212755
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	47/224 (21%)
		PH_ACAP	260..355	CDD:270070	24/109 (22%)
		ArfGap_ACAP	381..497	CDD:350064	49/116 (42%)
		ANKYR	<647..>768	CDD:440430	40/134 (30%)
		ANK repeat	687..713	CDD:293786	12/37 (32%)
		ANK repeat	715..746	CDD:293786	10/31 (32%)