Protein Alignment Asap and AGFG2

DIOPT Version :9

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_005250363.1
• Gene: AGFG2 / 3268
• HGNCID: 5177
• Length: 492
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 125/620 - (20%)
• Similarity: 202/620 - (32%)
• Gaps: 229/620 - (36%)

  Fly   438 GNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNS 502
            ||..|.:|..|. ||::.:..|..||..|||:.|.|...| |::|:::...|...::..::.||.
Human    43 GNRHCFECAQRG-VTYVDITVGSFVCTTCSGLLRGLNPPH-RVKSISMTTFTEPEVVFLQSRGNE 105

  Fly   503 TLNDIMEAKLG----RGKLQHESSMEERY-DFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNAD 562
            ....|.   ||    |..|..:|...::. :|::.||..||:.:.
Human   106 VCRKIW---LGLFDARTSLVPDSRDPQKVKEFLQEKYEKKRWYVP-------------------- 147

  Fly   563 MSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKAT---NPA 624
                              |....|.|     ..:...||      .:|...|:|....|   :||
Human   148 ------------------PDQVKGPT-----YTKGSAST------PVQGSIPEGKPLRTLLGDPA 183

  Fly   625 GLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIK 689
            ..|.|....::..:...|.|                 .||.::    .:...|:|.::
Human   184 PSLSVAASTSSQPVSQSHAR-----------------TSQARS----TQPPPHSSVKK------- 220

  Fly   690 REKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFA-----GGDSPVLRSRSSTCDS 749
                    .:||  |..:.|...|:..:..          |:||     ||.:| .:...:..|:
Human   221 --------ASTD--LLADIGGDPFAAPQMA----------PAFAAFPAFGGQTP-SQGGFANFDA 264

  Fly   750 IQS--SSSPIANCPSRQFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSS 812
            ..|  |||...:.|      |:|..|:  .|..:|    :..:.|..:.:.|.:.....|::|.:
Human   265 FSSGPSSSVFGSLP------PAGQASF--QAQPTP----AASRMLTESYSFGSSQGTPFGATPLA 317

  Fly   813 ASSQSVRAARNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPH 877
            .:||.     |||   :|:|..:                       .||...:...||.:|..
Human   318 PASQP-----NSL---ADVGSFL-----------------------GPGVPAAGVPSSLFGMA-- 349

  Fly   878 PPRHSQNFDASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGV-------------SQ 929
                                       |.:|.|:||...  ||||...|:             :|
Human   350 ---------------------------GQVPPLQSVTMG--GGGGSSTGLAFGAFTNPFTAPAAQ 385

  Fly   930 DPGGSGNG-SNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRP 993
            .|..|.|. ..|.|.|..   |...|.:|         .|....:||||..       .|:...|
Human   386 SPLPSTNPFQPNGLAPGP---GFGMSSAG---------PGFPQAVPPTGAF-------ASSFPAP 431

  Fly   994 KIPPPGPPSEREISNGQSNESISS--MDEGPVAPP 1026
            ..||..|..:::  ||.|...:.|  :.:.|::.|
Human   432 LFPPQTPLVQQQ--NGSSFGDLGSAKLGQRPLSQP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	32/107 (30%)
		Ank_2	554..662	CDD:403870	15/110 (14%)
		ANK repeat	586..622	CDD:293786	8/38 (21%)
		ANK repeat	624..662	CDD:293786	5/37 (14%)
		Ank_2	636..>693	CDD:403870	6/56 (11%)
		SH3_ASAP	1095..1149	CDD:212755
AGFG2	XP_005250363.1	ArfGap	40..147	CDD:295313	32/108 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900