DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Agap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_038939665.1	Gene:	Agap1 / 316611	RGDID:	1309244	Length:	1428	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	109/427 - (25%)
Similarity:	184/427 - (43%)	Gaps:	71/427 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 RSTPDFERVDNVPSSESRSGGAGYSLHQ----LQGDKH---H---GVTR--QGHLLKKSEGKVRR 327
            :||.:|:......::|.....:|..|..    ..||.|   |   |..|  :.||........|:
  Rat  1033 KSTSNFKADGLTGTAEGSHSHSGLRLRDPVAWRPGDLHPQFHTSLGQKRAPRPHLGSFWVSAKRK 1097

  Fly   328 VWQKRRCRVTSDGFL-DIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISY-NRPYHFQAEDEG 390
            .|:..|.     |.| :|:.:..:....:            ::...|.::|. .:.:||:|....
  Rat  1098 AWKLNRV-----GSLRNIYSSSSTNTEEQ------------EENLEFIIVSLTGQTWHFEATTYE 1145

  Fly   391 DQKAWMAVLVNCKEKALTKAFQHANPQMSPSLVELQK--TVIRYVQLLPGNDRCCDCGSRNDVTW 453
            ::.||:..:    |..:..:.|......:.|.:..|.  ..::.::.:.||..|.||.::|. .|
  Rat  1146 ERDAWVQAI----ESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNP-NW 1205

  Fly   454 ISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIM-EAKLGRGKL 517
            .|||.|.|:||:|||:||:||.|.||::||.||:.....:.:..::||...|.:. |...||.|.
  Rat  1206 ASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEEGSQGRTKP 1270

  Fly   518 QHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGA----DLTC 578
            ..:|:.||:..:|||||..|.::......:..|...|..|....|:..::.:.|.|:    :.||
  Rat  1271 SLDSTREEKERWIRAKYEQKLFLAPLPCTEFSLGQQLLHATAEEDLRTVILLLAHGSRDEVNETC 1335

  Fly   579 CLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHD 643
               ....|.||||||..:  |:.:     |:|.:...|::....     |..| ||||.......
  Rat  1336 ---GEGDGRTALHLACRK--GNVV-----LVQLLIWYGVDVMAR-----DAHG-NTALAYARQAS 1384

  Fly   644 RRECMKLLLRSGADYE------------LKNSQNKTA 668
            .:||:.:||:.|...|            ..||:|.::
  Rat  1385 SQECIDVLLQYGCPDERFVLMATPNLSRKNNSRNNSS 1421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	22/121 (18%)
		ArfGap_ASAP	425..541	CDD:350063	45/118 (38%)
		Ank_2	554..662	CDD:403870	30/123 (24%)
		ANK repeat	586..622	CDD:293786	11/35 (31%)
		ANK repeat	624..662	CDD:293786	12/49 (24%)
		Ank_2	636..>693	CDD:403870	10/45 (22%)
		SH3_ASAP	1095..1149	CDD:212755
Agap1	XP_038939665.1	Centaurin_gamma	561..722	CDD:133303
		PH_AGAP	837..>911	CDD:241281
		PH-like	<1123..1163	CDD:418428	8/43 (19%)
		ArfGap_AGAP2	1180..1288	CDD:350078	42/108 (39%)
		ANK repeat	1304..1332	CDD:293786	5/27 (19%)
		Ank_2	1307..1397	CDD:403870	28/105 (27%)
		ANK repeat	1339..1370	CDD:293786	11/42 (26%)
		ANK repeat	1372..1397	CDD:293786	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820