DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Asap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_038935098.1	Gene:	Asap1 / 314961	RGDID:	1307379	Length:	1147	Species:	Rattus norvegicus

Alignment Length:	1232	Identity:	492/1232 - (39%)
Similarity:	691/1232 - (56%)	Gaps:	185/1232 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..|:||||:.||..||:|||||:|.:|:.:||:|:.:|||.|:.||..|.|:||:||||:|||.
  Rat    22 PDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQ 86

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            .||.||....:.|::.|...:.:|.||:|.||:|||.:|||||.|:|.|:|.:::.|:|.:||:|
  Rat    87 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLL 151

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |.:|:|||||:|:|||||.||||.||.||||||:..||:.||:||||..|.:||||||||||:||
  Rat   152 KGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQL 216

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||:|..:||||.|::|||:||:||||..|:|:|||:|.:....||..|:..|:.|||.|||
  Rat   217 QMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDE 281

  Fly   263 DRRSLLDLRTVLRSTPDFERVD----NVPS--------SESRSGGAGYSLHQLQGDKHHGVTRQG 315
            :::.|..||.:::|:...:..:    .|||        |:||.|  |||:|||||:|.:|..::|
  Rat   282 EKKQLTALRDLIKSSLQLDPKEVGGLYVPSRANSSRRDSQSRQG--GYSMHQLQGNKEYGSEKKG 344

  Fly   316 HLLKKSEGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNR 380
            .|||||:| :|:|||:|:|.| .:|.|.|.||..::.|.::||||||:||..:||:.|||||:||
  Rat   345 FLLKKSDG-IRKVWQRRKCAV-KNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNR 407

  Fly   381 PYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDC 445
            .||||||||.|..||::||.|.||:|||.||:........||.:|.|.:|..||.|||||.||||
  Rat   408 TYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSTGENSLEDLTKAIIEDVQRLPGNDICCDC 472

  Fly   446 GSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEA 510
            || ::.||:|.|.|||.||:|||:||::|||.||||||.||.|.|:.||:|:.:||::.||||||
  Rat   473 GS-SEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEA 536

  Fly   511 KL--GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEG 573
            .|  ...|....|.|..|.::|.||||..|:..:||:..:....:|.:|:.:.|:..|:||:|||
  Rat   537 NLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCASSSAKLNELLEAIKSRDLLALIQVYAEG 601

  Fly   574 ADLTCCL--PSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTAL 636
            .:|...|  |..:.|||||||||.....::||:||||:||.  ..|:|.|:..        ||.|
  Rat   602 VELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNC--GNLDKQTSVG--------NTVL 656

  Fly   637 HLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTD 701
            |.|:::.:.||:||||||....::.|...:|||||||.:....|.:|:..|...:.:...|:..:
  Rat   657 HYCSMYGKPECLKLLLRSKPTVDIVNQNGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYE 721

  Fly   702 WNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRS----STCDSIQSSSSPIANCPS 762
            |||..::  .|.|||:  :|::            .||:.:.||    |.|.|  ||.||......
  Rat   722 WNLRQDE--MDESDDD--LDDK------------PSPIKKERSPRPQSFCHS--SSISPQDKLAL 768

  Fly   763 RQFTLPSGLPSYTHSAGTSPKQHISVGQ-----YLGSATNVGGN--------GPGNGGSSPSSAS 814
            ..|:.|            ..||.:|.|.     ::.::|::..:        .|.|.|..|:...
  Rat   769 PGFSTP------------RDKQRLSYGAFTNQIFVSTSTDLPTSPTSEAPPLPPRNAGKGPTGPP 821

  Fly   815 SQSVRAARNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPG---TLGSASSSSFYGTLP 876
            |..      .|..|:..|.              ::|.|:..|.||||   ||....|     .||
  Rat   822 STL------PLGTQTSSGS--------------STLSKKRPPPPPPGHKRTLSDPPS-----PLP 861

  Fly   877 HPPRH-------------SQNFDASDIRAINHK--NQSLDVAYG-----TLPH---LRSVESSPR 918
            |.|.:             |.:..|:....::.:  ..|...|.|     .||.   ||..|:|
  Rat   862 HGPPNKGAIPWGNDVGPSSSSKTANKFEGLSQQASTSSAKTALGPRVLPKLPQKVALRKTETS-- 924

  Fly   919 GGGGYGYGVSQD-----PGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLV--LPP- 975
                  :.:|.|     |......|..|.:|       ::.|.|:...:.:.||....:  |||
  Rat   925 ------HHLSLDRANIPPETFQKSSQLSELP-------QKPPLGDLPPKPMELAPKPQIGELPPK 976

  Fly   976 TGELPTLKHVDKSAL----TRPKIP--PPGP-----PSEREISNGQSNESISSMDEGPVAPPRKL 1029
            .||||     .|..|    .:|::.  ||.|     |.:.::.:..:....|.: ...|.||.::
  Rat   977 PGELP-----PKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQASDL-SAKVQPPSEV 1035

  Fly  1030 VNQSANFPDYESWHT-DMDSSGGGLDHSAESNVSSSDNDRLNSSPDNPSKTGGAGLGGKFHYNGQ 1093
            ..:|         || |:..:....| :.:...|...||...:.|:.|.........||   |..
  Rat  1036 TQRS---------HTGDLSPNVQSRD-AIQKQASEDSNDLTPTLPETPVPLPRKINTGK---NKV 1087

  Fly  1094 RRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGIIEGQPTRKGMFPVSFVHMLPD 1155
            ||.:.:|||.|||||||.|.|||::||..|  :|:.|..|.|||||.|||:|||||||:|.|
  Rat  1088 RRVKTIYDCQADNDDELTFIEGEVIIVTGE--EDQEWWIGHIEGQPERKGVFPVSFVHILSD 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	122/213 (57%)
		PH_ASAP	302..410	CDD:270071	62/107 (58%)
		ArfGap_ASAP	425..541	CDD:350063	65/117 (56%)
		Ank_2	554..662	CDD:403870	45/109 (41%)
		ANK repeat	586..622	CDD:293786	19/35 (54%)
		ANK repeat	624..662	CDD:293786	13/37 (35%)
		Ank_2	636..>693	CDD:403870	22/56 (39%)
		SH3_ASAP	1095..1149	CDD:212755	32/53 (60%)
Asap1	XP_038935098.1	BAR_ASAP1	54..268	CDD:153325	122/213 (57%)
		PH_ASAP	331..437	CDD:270071	62/107 (58%)
		ArfGap_ASAP1	452..573	CDD:350073	66/121 (55%)
		ANK repeat	616..649	CDD:293786	19/34 (56%)
		Ank_2	620..>692	CDD:403870	34/81 (42%)
		ANK repeat	651..682	CDD:293786	13/38 (34%)
		PHA03247	<739..1051	CDD:223021	83/392 (21%)
		SH3_ASAP1	1089..1145	CDD:212898	36/57 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1733
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7684
Inparanoid	1	1.050	755	1.000	Inparanoid score	I532
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm45513
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980