DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Git2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_017453834.1	Gene:	Git2 / 304546	RGDID:	1359708	Length:	761	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	156/717 - (21%)
Similarity:	244/717 - (34%)	Gaps:	206/717 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 LPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMG 500
            |..||.|.|| |..|.:|.|:|.|.|:|.:|..|||.||.|.|:::.|.........|.:...:.
  Rat     5 LRSNDVCADC-SGPDPSWASVNRGTLICDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLY 68

  Fly   501 NSTLNDIMEAKL--------GRGKLQHESSME-ERYDFIRAKYVAKRYVMR-TCSDDNDLRCDLE 555
            ::..|.|.|..|        ||.|...:..:. .:.:||||||....:|.| .|.||:
  Rat    69 SNGANSIWEHSLLDPASVMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDD------- 126

  Fly   556 QAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKA 620
             :|...|:|:.|.......:|          ||.|.|..|....:..|         |.||
  Rat   127 -SVTAKDLSKQLHSSVRTGNL----------ETCLRLLSLGAQANFFH---------PEKG---- 167

  Fly   621 TNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIE 685
                        :|.||:.:...:....:||...|||....:|..||.:|.|::.||   |||.|
  Rat   168 ------------STPLHVASKAGQILQAELLAVYGADPGTHDSSGKTPVDYARQGGH---RELAE 217

  Fly   686 CAIK-----REKSAF-------DHIN---------TDWNLPNEDGSTDFSD-------------- 715
            ..::     .::.||       ||.|         .|..|     |.|.|:
  Rat   218 RLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADRRL-----SLDLSELAKAAKKKLQSLSN 277

  Fly   716 ---DETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSGLPSY--T 775
               :|..:|......|            |...:...:.|:.|:.:.......| ||.. |.|  |
  Rat   278 HLFEELAMDVYDEVDR------------RETDAVWLATQNHSTLVTETTVVPF-LPVN-PEYSST 328

  Fly   776 HSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDLGGHVTGAR- 839
            .:.|.......:..::.....::..:.......||.|.|..:|.....:::.|     |.|.::
  Rat   329 RNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSNQ-----HSTESQD 388

  Fly   840 ------KSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNF-------DASD-- 889
                  .|.::.....::.|.:......:|.|..|..        |...|.|       .||:
  Rat   389 NDQPDYDSVASDEDTDVETRASRTNRQKSLDSDLSDG--------PVTVQEFMEVKHALVASEAK 445

  Fly   890 ----IRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFG 950
                ::..|:.:..|.:....|..|:|..||.|                 ..:..|.....|...
  Rat   446 RQQLMKVNNNLSGELRIMQKKLQTLQSENSSLR-----------------RQATASACQVQTASD 493

  Fly   951 HKRSPSGESLNRNIHLAGAK---LVLPPTGELPTLKHVDKSALTRPKIPPPGPPSEREISNGQSN 1012
            ||.:.|..||.|.....|::   :....:|:.|.|              |.|..:..|
  Rat   494 HKDTVSHSSLKRRPSARGSRPMSMYETGSGQKPYL--------------PMGEANHPE------- 537

  Fly  1013 ESISSMDEGPVAPPRK-LVNQSANFPDYE---SWHTDMDSSGGGLDHSAESNVSSSDNDRLNSSP 1073
            ||.:.:...|....|. ||..|::.|.:.   ||..|            ||...:|..::.||:|
  Rat   538 ESRTRLQPFPTHIGRSALVTSSSSLPSFPSTLSWSRD------------ESTRRASRLEKQNSTP 590

  Fly  1074 DN 1075
            ::
  Rat   591 ES 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	37/113 (33%)
		Ank_2	554..662	CDD:403870	22/107 (21%)
		ANK repeat	586..622	CDD:293786	9/35 (26%)
		ANK repeat	624..662	CDD:293786	8/37 (22%)
		Ank_2	636..>693	CDD:403870	18/61 (30%)
		SH3_ASAP	1095..1149	CDD:212755
Git2	XP_017453834.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810