DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Appl1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_038951064.1	Gene:	Appl1 / 290537	RGDID:	1309388	Length:	720	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	168/805 - (20%)
Similarity:	303/805 - (37%)	Gaps:	187/805 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN-----THVD 71
            :|||..|  ||.|          |..:||.||........:.:|.:|:..|:::.|     ||:.
  Rat     9 IEETLED--SPQT----------RSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLT 61

  Fly    72 NEMFMVRALER--LGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKS 134
            :::......:|  |||     |:..:.:...:||.|..|||:....|...:.:.:|||:....:.
  Rat    62 SKLLKEYEKQRFPLGG-----DDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPISQFKER 121

  Fly   135 ELRGVKGDMKRPFDKAAKDYEA---KFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQ 196
            :|:.:. .:|..|..|:.|::|   ::.::.|:     :|...|:.|     |.|::...|:...
  Rat   122 DLKEIL-TLKEVFQIASNDHDAAINRYSRLSKK-----RENDKVKYE-----VTEDVYTSRKKQH 175

  Fly   197 LQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQD 261
            .....|......::.|..|.||:.|:.|..|..::||.|.:.:.      |.|.|.|..|.....
  Rat   176 QTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLN------GQLEEFLANIGTSVQ 234

  Fly   262 EDRRSL-LDLRTVLRSTPDFERVDN-----------VPSSESRSGGAGY-------SLHQLQGDK 307
            ..||.: .|:.|:.::..|.|...:           .|.:.:.:..|||       .|.....|:
  Rat   235 NVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDR 299

  Fly   308 HHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGF-LDIFHADESKPPTRVNLLTCQIKPVP-DDK 370
            ....|:.|:|:.::.|.|            :.|. :||.:              |.:..|. :|:
  Rat   300 QFYFTQGGNLMSQARGDV------------AGGLAMDIDN--------------CSVMAVDCEDR 338

  Fly   371 R-GFDLISYN--RPYHFQAEDEGDQKAWMAVLVNCK---------EKALTKAFQHANPQMSPSLV 423
            | .|.:.|::  :....|||.:.|.:.|:..:.|..         |:...:..|.|...::||..
  Rat   339 RYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPS 403

  Fly   424 ELQKTVIRYVQLLPGND------RCCDCGS----RNDVTWISLN----------FGIL--VCIQC 466
            ..|    |:..|.||..      |....||    ..::..:||:          |.|:  ||...
  Rat   404 FQQ----RHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQ 464

  Fly   467 SGVHRDLGVHHSRIQSL---------TLDNLTTANLLIARAMGNSTLNDIMEAKLGRGKLQHESS 522
            .|..:..|....|....         ..:..|..| :..|.:.||.|:.:...:. .|.::.:|
  Rat   465 PGQAKAFGQGGRRTNPFGESGGSTKSETEGRTDCN-VHPRVISNSILHQLFIVRF-LGSMEVKS- 526

  Fly   523 MEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLP-----S 582
             ::..|.:   |...|.::...:..|..|......:|..|..:|:....:...||..||     :
  Rat   527 -DDHPDVV---YETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPYVVLYA 587

  Fly   583 SDAGETALHLAVLREMG----STLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHD 643
            :......|...|||..|    |.|..|.::.:: ..:| .|..:..||    .|..|||  |..|
  Rat   588 THQENKRLFGFVLRTSGGRSESNLSSVCYIFES-NNEG-EKICDSVGL----AKQIALH--AELD 644

  Fly   644 RRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNED 708
            ||...|       ..|::..:.|...:::|:.           .|:::......:....:.|::.
  Rat   645 RRASEK-------QKEIERVKEKQQKELSKQK-----------EIEKDLEEQSRLIAASSRPSQS 691

  Fly   709 G-------STDFSDDETVIDERKSR 726
            |       |:..|::..:.:|.|.|
  Rat   692 GSEGQLVLSSSQSEESDLGEEGKKR 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	51/223 (23%)
		PH_ASAP	302..410	CDD:270071	22/121 (18%)
		ArfGap_ASAP	425..541	CDD:350063	28/146 (19%)
		Ank_2	554..662	CDD:403870	29/116 (25%)
		ANK repeat	586..622	CDD:293786	10/39 (26%)
		ANK repeat	624..662	CDD:293786	12/37 (32%)
		Ank_2	636..>693	CDD:403870	11/56 (20%)
		SH3_ASAP	1095..1149	CDD:212755
Appl1	XP_038951064.1	BAR_APPL1	20..234	CDD:153315	55/235 (23%)
		BAR-PH_APPL	252..376	CDD:270067	28/149 (19%)
		PTB_APPL	506..637	CDD:269980	30/142 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910