Protein Alignment Asap and Acap1

DIOPT Version :10

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001099266.2
• Gene: Acap1 / 287443
• RGDID: 1305360
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 799
• Identity: 189/799 - (23%)
• Similarity: 311/799 - (38%)
• Gaps: 183/799 - (22%)

  Fly    38 IGVLEERLEFDREGLTKLKKAVKAIHNSGNTHV-DNEMFMVRA--LERLGGKVIEQDEPDIGAAF 99
            :..||.|||       ||.|....:..||:.:: .:..|:|..  |..||     ..||.:....
  Rat    28 VSELETRLE-------KLLKLGSCLLESGHHYLAASRAFVVGICDLAHLG-----PPEPMMAECL 80

  Fly   100 LKFSVVTKE--------LSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFDKAAKDYEA 156
            .||:.....        |.|...||.|.|..:|        |..|||.: :.:|.|.:.|:..||
  Rat    81 EKFTESLNHKLDSHAELLDATQHTLQQQIQTLV--------KEGLRGFR-EARRDFWRGAESLEA 136

  Fly   157 KF---IKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIKTKTGIELL 218
            ..   .::.:.:..:|::||..            :...|.:|:.:..:|.|:...|:.|...:::
  Rat   137 ALSHNAEVPRRRVQEAEDAGTA------------LRTARAVYRSRALDYALQVNVIEDKRKFDIM 189

  Fly   219 QHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDEDRRSLLDLRTVLRSTPDFERV 283
            :.::....|.:.||:.|.:.:.....|..:|..:||.:......:||. ::.|.||....:....
  Rat   190 EFILRLVEAQATYFQQGHEELNQLAQYRKELGAQLHNLVLNSARERRD-MEQRHVLLKQKELGGE 253

  Fly   284 DNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGFLDIFHAD 348
            :..||.:..|.               |:..:|||.|::.... :.|.:|...:.::   .:.:..
  Rat   254 EPEPSLKEGSS---------------GLVMEGHLFKRASNAF-KTWSRRWFTIQNN---QLVYQK 299

  Fly   349 ESKPPTRV---NLLTCQIKPVPDDKRG--FDLISYNRPYHFQAEDEGDQKAWMAVLVNCKEKALT 408
            :.|.|..|   :|..|.:|..||.:|.  |:::|.::....||:.|...:.|    |:..:.::.
  Rat   300 KYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLW----VSAVQSSIA 360

  Fly   409 KAFQHANPQMSP-------------SLVELQ-------------KTVIRYVQLLPGNDRCCDCGS 447
            .||..|:.:.||             |...|.             ..|...||.:.||.:|||| .
  Rat   361 SAFSQAHLENSPRGPGQVSGYHSPGSAATLSCGGPARGREPGGVGQVAAQVQSVDGNAQCCDC-K 424

  Fly   448 RNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAK- 511
            .....|.|:|.||.:||||||:||.||||.|:::|||||:.....:.:...:||..:|.|.||:
  Rat   425 EPAPEWASINLGITLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVVINQIYEARV 489

  Fly   512 --LGRGKLQHESSMEERYDFIRAKYVAKRY----------------------------------V 540
              :...|.....|.:|:..:|.||||.|::                                  :
  Rat   490 EAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPSIRPQSGI 554

  Fly   541 MRTCSD--DNDL------RCDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLRE 597
            :|:.|:  ..|:      ....:.|.....:..:....|.|||:...    :||:......:...
  Rat   555 VRSKSESPSEDIGSLHPGALLFQAAGYPPSLPTMADALAHGADVNWV----NAGQGNATPLIRAT 615

  Fly   598 MGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCAL-HDRRECMKLLLRSGADYELK 661
            ..::|...:||:||    |.|  .|.|   |..|:....|...| |....|  |.|:.|||...:
  Rat   616 AANSLLACEFLLQN----GAN--VNQA---DSAGRGPLHHATILGHTGLAC--LFLKRGADLGAR 669

  Fly   662 NSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSR 726
            :::.:..|.||.|..:.....|:..|..||..|            ..|.|   .|||.:|    .
  Rat   670 DTEGRDPLTIAMETTNADIVTLLRLAKMREAEA------------AQGQT---GDETYLD----I 715

  Fly   727 SRPPSFAGGDSPVLRSRSS 745
            .|..|....|.|...||.|
  Rat   716 FRDFSLMASDDPEKLSRRS 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	49/224 (22%)
		PH_ASAP	302..410	CDD:270071	23/112 (21%)
		ArfGap_ASAP	425..541	CDD:350063	48/165 (29%)
		ANKYR	<573..709	CDD:440430	34/136 (25%)
		ANK repeat	586..622	CDD:293786	8/35 (23%)
		ANK repeat	624..662	CDD:293786	12/38 (32%)
		Vac17	<706..>788	CDD:435863	13/40 (33%)
		SH3_ASAP	1095..1149	CDD:212755
Acap1	NP_001099266.2	BAR_ACAP1	18..217	CDD:153323	48/221 (22%)
		PH_ACAP	268..364	CDD:270070	23/103 (22%)
		ArfGap_ACAP1	405..524	CDD:350077	47/119 (39%)
		ANK repeat	575..602	CDD:293786	5/30 (17%)
		ANKYR	<592..704	CDD:440430	35/138 (25%)
		ANK repeat	606..637	CDD:293786	9/39 (23%)
		ANK repeat	639..670	CDD:293786	10/32 (31%)