DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and APPL1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_036228.1	Gene:	APPL1 / 26060	HGNCID:	24035	Length:	709	Species:	Homo sapiens

Alignment Length:	746	Identity:	152/746 - (20%)
Similarity:	278/746 - (37%)	Gaps:	181/746 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN-----THVD 71
            :|||..|  ||.|          |..:||.||........:.:|.:|:..|:::.|     ||:.
Human     9 IEETLED--SPQT----------RSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLT 61

  Fly    72 NEMFMVRALER--LGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKS 134
            :::......:|  |||     |:..:.:...:||.|..|||:....|...:.:.:|||:....:.
Human    62 SKLLKEYEKQRFPLGG-----DDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKER 121

  Fly   135 ELRGVKGDMKRPFDKAAKDYEA---KFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQ 196
            :|:.:. .:|..|..|:.|::|   ::.::.|:     :|...|:.|     |.|::...|:...
Human   122 DLKEIL-TLKEVFQIASNDHDAAINRYSRLSKK-----RENDKVKYE-----VTEDVYTSRKKQH 175

  Fly   197 LQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTI-EHFGTYIGDLSEKLHEIKQKQ 260
            .....|......::.|..|.||:.|:.|..|..::||.|.:.: |....::.::...:..::::.
Human   176 QTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREM 240

  Fly   261 DEDRRSLLDLRTVLRSTPDFERVDN-----------VPSSESRSGGAGY-------SLHQLQGDK 307
            |.      |:.|:.::..|.|...:           .|.:.:.:..|||       .|.....|:
Human   241 DS------DIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDR 299

  Fly   308 HHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGF-LDIFHADESKPPTRVNLLTCQIKPVP-DDK 370
            ....|:.|:|:.::.|.|            :.|. :||.:              |.:..|. :|:
Human   300 QFYFTQGGNLMSQARGDV------------AGGLAMDIDN--------------CSVMAVDCEDR 338

  Fly   371 R-GFDLISYN--RPYHFQAEDEGDQKAWMAVLVNCK---------EKALTKAFQHANPQMSPSLV 423
            | .|.:.|::  :....|||.:.|.:.|:..:.|..         |:...:..|.|...::||..
Human   339 RYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPS 403

  Fly   424 ELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNL 488
            ..|    |:..|.|.      .|.....|..:.:.|            .||...:.:.:|:||:|
Human   404 FQQ----RHESLRPA------AGQSRPPTARTSSSG------------SLGSESTNLAALSLDSL 446

  Fly   489 TTANLLI---------------ARAMGNS--TLNDIMEAKLGRGKLQHESSMEERYDFIR----- 531
            ...:..|               |:|.|..  ..|...|:. |..|.:.|.|:..:...:|
Human   447 VAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESG-GSTKSETEDSILHQLFIVRFLGSM 510

  Fly   532 ---------AKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLP-----S 582
                     ..|...|.::...:..|..|......:|..|..:|:....:...||..||     :
Human   511 EVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYA 575

  Fly   583 SDAGETALHLAVLREMG----STLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHD 643
            :......|...|||...    |.|..|.::.:: ..:| .|..:..||    .|..|||  |..|
Human   576 THQENKRLFGFVLRTSSGRSESNLSSVCYIFES-NNEG-EKICDSVGL----AKQIALH--AELD 632

  Fly   644 RRECMKLLLRSGADYELKNSQNKTALDIAKE 674
            ||...|       ..|::..:.|...::.|:
Human   633 RRASEK-------QKEIERVKEKQQKELNKQ 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	51/224 (23%)
		PH_ASAP	302..410	CDD:270071	22/121 (18%)
		ArfGap_ASAP	425..541	CDD:350063	26/146 (18%)
		Ank_2	554..662	CDD:403870	28/116 (24%)
		ANK repeat	586..622	CDD:293786	9/39 (23%)
		ANK repeat	624..662	CDD:293786	12/37 (32%)
		Ank_2	636..>693	CDD:403870	10/39 (26%)
		SH3_ASAP	1095..1149	CDD:212755
APPL1	NP_036228.1	Required for RAB5A binding	1..428		100/488 (20%)
		BAR_APPL1	20..234	CDD:153315	51/229 (22%)
		BAR-PH_APPL	252..376	CDD:270067	28/149 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..434		11/58 (19%)
		F&H	403..414		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..491		6/24 (25%)
		PTB_APPL	490..625	CDD:269980	27/140 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..709		2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810