DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and cnt5

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_595897.1	Gene:	cnt5 / 2539865	PomBaseID:	SPBC17G9.08c	Length:	870	Species:	Schizosaccharomyces pombe

Alignment Length:	705	Identity:	143/705 - (20%)
Similarity:	291/705 - (41%)	Gaps:	154/705 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PPSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSG 66
            ||....|:..:::|..:..           |..|.|| :..||...|...:  |||.:|.|.:..
pombe   234 PPLTNPVARDIDQTEPEDG-----------PLFRATI-LNYERTTHDMRMV--LKKLIKRIEHVA 284

  Fly    67 NTHVDNEMFM-----VRALERLGGKVIEQDEPDIGAAFLK--FSVVTKELSALMKTLMQNINNIV 124
            ::|  ..::|     :.|.||     :....|.....||.  ::...:...:......:.:.|.:
pombe   285 HSH--GLLYMSYKELMSAFER-----VATINPPAFKPFLDHYYAAAAQSFDSFNIDRARLLRNFL 342

  Fly   125 MFPVDSMLKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEME 189
            :.|:..:..::::.| ...|:.|::.::||   :..:.:......||....:|:      ..:..
pombe   343 IEPLRKIYDTDIKNV-STKKKDFEETSRDY---YTSLSRYLSKSEKETSSDKTK------ESKFA 397

  Fly   190 KERRLYQLQTCEYLLKYKDIK-TKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSE-- 251
            .::|.::|...:|....:||. .:.|.|:|..|..:.....|.....|..|:.....|..|.:
pombe   398 AKKRDFELSRFDYYSYMQDINGGRKGQEVLSVLTSFAANDYNLIHSSLTDIDALRPSIIQLQDIV 462

  Fly   252 ----KLHEIKQKQDEDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVT 312
                |..::.:.:.|:||     |.:..|:.:.|..|...::::         ::.:.|:... .
pombe   463 TEANKEFQLLRAEREERR-----RYIETSSRELEDKDAEIAAQA---------YKAKVDQDTS-A 512

  Fly   313 RQGHLL--KKSEGKVRRV----WQK--------RRCRVTS-DGFLDIFHADESKPPTRVNLLTCQ 362
            :||.||  .||...::.|    |.|        :.|...: ...|::    .::|   ::||...
pombe   513 KQGLLLAFSKSTSDLQVVGKSGWHKYWVVLDHGKICEYANWKQSLEL----HTEP---IDLLMAT 570

  Fly   363 IKPVPDDKRG--FDLISYNRPYHFQAEDEGDQKAWMAVL----------------VNCKE----- 404
            ::|.....|.  |::|:......:||..:.:..:|:..:                :|.:|
pombe   571 VRPAQSVSRKFCFEVITPQTKRTYQATSKAEMHSWIEAIQYSISESIVQKGKGTSMNSEETSVKH 635

  Fly   405 -------KALTKAFQHANPQ------------MSPSLVELQKTVIRYVQLLPGNDRCCDCGSRND 450
                   |||.:.....:|.            .|||||:..|      ::...:..|.||.:...
pombe   636 GPTSTIGKALQRVASVTSPSRHNSDSKEKKQTKSPSLVKTLK------EMHSSDQSCADCNTTAR 694

  Fly   451 VTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRG 515
            |.|.::||.:::||.|||:||.||.|.::|:|||||......:.:..|.|||.:|:|.|..:...
pombe   695 VEWCAINFPVVLCIDCSGIHRSLGTHITKIRSLTLDKFNPETVDLLYATGNSFVNEIYEGGITDW 759

  Fly   516 KLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCL 580
            |:::..:.|.|..|::.||:.||::..:.|  :|....|.:::.::::.:.:...|.|||:..
pombe   760 KIKNFENQERRVQFVKDKYLYKRFIKSSFS--HDPNTGLLESIEHSNLKEAVLCLALGADVNY-- 820

  Fly   581 PSSDAGETALHLAVLRE----------MGSTLHIVDFLIQNMPPKG----LNKAT 621
                  :.|:..|:|:.          .|::|::.:..::.:..:.    :|:||
pombe   821 ------QRAVVKALLKNNYLIAELLTLNGASLNVDEVTMETLSARAQAFVMNRAT 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	42/221 (19%)
		PH_ASAP	302..410	CDD:270071	27/152 (18%)
		ArfGap_ASAP	425..541	CDD:350063	39/115 (34%)
		Ank_2	554..662	CDD:403870	13/82 (16%)
		ANK repeat	586..622	CDD:293786	8/50 (16%)
		ANK repeat	624..662	CDD:293786
		Ank_2	636..>693	CDD:403870
		SH3_ASAP	1095..1149	CDD:212755
cnt5	NP_595897.1	BAR_ArfGAP_fungi	257..455	CDD:153292	40/217 (18%)
		PH-like	513..614	CDD:302622	21/107 (20%)
		PH	532..614	CDD:278594	14/88 (16%)
		COG5347	671..>870	CDD:227651	57/215 (27%)
		ArfGap	674..787	CDD:279720	39/118 (33%)
		ANK repeat	791..821	CDD:293786	6/37 (16%)
		ANK repeat	822..847	CDD:293786	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	89	1.000	Domainoid score	I2110
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9294
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810