DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Arfgap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006235793.1	Gene:	Arfgap1 / 246310	RGDID:	708452	Length:	425	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	100/489 - (20%)
Similarity:	176/489 - (35%)	Gaps:	140/489 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 KTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTA 491
            :.|::.|:....|:.|.:||:.|. .|:|:.:||.:|::|||.||.||||.|.::|:|:|.....
  Rat     7 RKVLKEVRAQDENNVCFECGAFNP-QWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDI 70

  Fly   492 NLLIARAMGNSTLNDIMEAKLGRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQ 556
            .|...:|.||:...:.:||   :...:...|::::|....|...  |..:.|.::..:...:...
  Rat    71 ELEKMKAGGNAKFREFLEA---QDDYEPSWSLQDKYSSRAAALF--RDKVATLAEGKEWSLESSP 130

  Fly   557 AVVNADMSQLLQVWA----EGADLTCCLPS------SDAGETALHLAVLREMGS-----TLHIVD 606
            |          |.|.    :....|...|:      :.:|:.|....:..::||     ....|.
  Rat   131 A----------QNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVG 185

  Fly   607 FLIQNMPPK----------------GLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSG 655
            | ...:||:                |.:..|..|.......|..|                .:.|
  Rat   186 F-GNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGA----------------TKFG 233

  Fly   656 ADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSA--FDHINT---------------DWN 703
            :....|....|...:.|.|:||:....:::.|.::.|..  ||.:::               .|
  Rat   234 SQASQKFWGYKQQSEPASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGW- 297

  Fly   704 LPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCD-----SIQSSSSPIANCPSR 763
               .|.:|.||.......:|.........:.||:    |::||.|     :..|:..|.|..||.
  Rat   298 ---RDVTTFFSGKAEDTSDRPLEGHSYQNSSGDN----SQNSTIDQSFWETFGSAEPPKAKSPSS 355

  Fly   764 QFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQ 828
            .        |:|.:       ..|.|:....:.::.|:|                 :|.|:.|..
  Rat   356 D--------SWTCA-------DASTGRRSSDSWDIWGSG-----------------SASNNKNSN 388

  Fly   829 SD-----LGGHVTGARKSTSTANMNSLKKRTAPA 857
            ||     .|....|..|:|         |:.||:
  Rat   389 SDGWESWEGASGEGRAKAT---------KKAAPS 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	35/113 (31%)
		Ank_2	554..662	CDD:403870	19/138 (14%)
		ANK repeat	586..622	CDD:293786	9/56 (16%)
		ANK repeat	624..662	CDD:293786	4/37 (11%)
		Ank_2	636..>693	CDD:403870	8/56 (14%)
		SH3_ASAP	1095..1149	CDD:212755
Arfgap1	XP_006235793.1	ArfGap	7..114	CDD:279720	35/112 (31%)
Arfgap1	XP_006235793.1	DUF4048	<325..376	CDD:289997	15/69 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810