Protein Alignment Asap and Agfg2

DIOPT Version :10

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001290195.1
• Gene: Agfg2 / 231801
• MGIID: 2443267
• Length: 490
• Species: Mus musculus
• Alignment Length: 689
• Identity: 136/689 - (19%)
• Similarity: 206/689 - (29%)
• Gaps: 288/689 - (41%)

  Fly   438 GNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNS 502
            ||..|.:|..|. ||::.:..|..||..|||:.|.|...| |::|:::...|...:|..::.||.
Mouse    43 GNRHCFECAQRG-VTYVDITVGSFVCTTCSGLLRGLNPPH-RVKSISMTTFTEPEVLFLQSRGNE 105

  Fly   503 TLNDIMEAKLG----RGKLQHESSMEERY-DFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNAD 562
            ....|.   ||    |..|..:|...::. :|::.||..||:.
Mouse   106 VCRKIW---LGLFDARTSLIPDSRDPQKVKEFLQEKYEKKRWY---------------------- 145

  Fly   563 MSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLL 627
                                                             :||:.:
Mouse   146 -------------------------------------------------VPPEQV---------- 151

  Fly   628 DVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREK 692
                                      .|..|. |.|.:.|.:..:...| ...|.|:...:   .
Mouse   152 --------------------------KGPSYS-KGSVSATPVQGSVPEG-KPIRTLLGDPV---P 185

  Fly   693 SAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPI 757
            |..|..:|.    ::.||             :|::|..|.|....|  .|.|||   .::|:..:
Mouse   186 SLSDPASTS----SQPGS-------------QSQARSSSQARSSQP--PSHSST---KKASTDLL 228

  Fly   758 ANCPSRQFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGG--------SSPSSAS 814
            |:.....|..|..:|::....|      ..|||           .|.:||        |||||::
Mouse   229 ADIGGDPFAAPQVVPAFASFPG------FGVGQ-----------TPAHGGFANFDAFSSSPSSST 276

  Fly   815 SQSVRAARNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPP 879
            ..|:..     ::|:......|.|.....|.:.              :.||...|:| |..|
Mouse   277 FGSLPP-----SVQAPFQAQPTPAANRMLTGSY--------------SFGSGQMSAF-GVAP--- 318

  Fly   880 RHSQNFDASDIRAINHKNQSLDVAYGTLPHLRSVESSPR--GGG--GYGYGV--------SQDPG 932
                      :.|.:..|...||. |.|        .||  .||  |..:|:        |..||
Mouse   319 ----------LAAASQPNNLADVG-GLL--------GPRMAAGGLPGSVFGMPSQVPALQSAVPG 364

  Fly   933 GSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSAL------- 990
            .||:|.    :|    ||...:|               ...|...:||:......:.|
Mouse   365 VSGSGG----LP----FGAYTNP---------------FATPAQAQLPSTNPFQPNGLASGPGFG 406

  Fly   991 ---TRPKIPPPGPPSEREISNGQSNESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGG 1052
               .||.:..|.|||          .:.:|....||.|.:      |...|.::     .||.|.
Mouse   407 MSSVRPGLLQPVPPS----------GAFASPFSAPVFPTQ------AGLADQQN-----GSSFGD 450

  Fly  1053 LDHSAESNVSSSDNDRLNSSP----DNPSKTGGAGLGGK 1087
            |.       :|....|..|.|    .||..||.:....|
Mouse   451 LG-------TSKLGQRPLSQPAGISTNPFMTGSSAFASK 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	33/107 (31%)
		ANKYR	<573..709	CDD:440430	13/135 (10%)
		ANK repeat	586..622	CDD:293786	2/35 (6%)
		ANK repeat	624..662	CDD:293786	2/37 (5%)
		Vac17	<706..>788	CDD:435863	17/81 (21%)
		SH3_ASAP	1095..1149	CDD:212755
Agfg2	NP_001290195.1	ArfGap_AGFG2	30..146	CDD:350090	33/178 (19%)
		PHA03247	<146..465	CDD:223021	97/491 (20%)