DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Asap and Asap3

DIOPT Version :10

Sequence 1:NP_001014504.1 Gene:Asap / 35783 FlyBaseID:FBgn0050372 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001008233.1 Gene:Asap3 / 230837 MGIID:2684986 Length:904 Species:Mus musculus


Alignment Length:953 Identity:355/953 - (37%)
Similarity:512/953 - (53%) Gaps:82/953 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PSLIAVSEFVEETRSDYSSPT-TSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSG 66
            |..::|:||:..|..|.|||. .:.||::||.||......||.||.|:..|.::||||:|||:||
Mouse     2 PEQLSVAEFLAVTAEDLSSPAGAAAFAAKMPRCRGAALAREEALEGDQAILQRIKKAVRAIHSSG 66

  Fly    67 NTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSM 131
            ..||:.|.....|:|.||...:.|:..::...||..:|.|:|::||.|.|:||:||||.||:||:
Mouse    67 LGHVETEEHYREAVEALGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDSL 131

  Fly   132 LKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQ 196
            :|..||..:.|.|:..:||.||||:|..|:|||:.......|      ...|::::.::|||::|
Mouse   132 MKGHLRDGRHDSKKHLEKAWKDYESKVAKLEKERDRARFPGG------SHGVMSQDTQRERRVFQ 190

  Fly   197 LQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQD 261
            |..||||:|..:.:.|.|.:.||.||:::||..|:|:||.:..:....:|..|:..:|.::|.|:
Mouse   191 LHMCEYLVKAGESQVKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLSPFIDKLAASVHGLRQAQE 255

  Fly   262 EDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVR 326
            |:...|..||..||.....|..::.|:  .::.|.|||:||.||:|..|..:.|.|.|||:| :|
Mouse   256 EELHKLTQLRDSLRGMLHLESREDHPN--RKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDG-IR 317

  Fly   327 RVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGD 391
            ||||||:|.| ..|.|.|.|:..::||.::.|||||::|.|::||.|||:::||.|||.||||.:
Mouse   318 RVWQKRKCGV-KYGCLTISHSMINRPPVKLPLLTCQVRPNPEEKRCFDLVTHNRTYHFHAEDEQE 381

  Fly   392 QKAWMAVLVNCKEKALTKAFQHANP---------QMSPSLVELQKTVIRYVQLLPGNDRCCDCGS 447
            .:||::||.|.|::||:.|| |..|         ::.....:|...::..|:..||||||||||:
Mouse   382 CEAWVSVLQNSKDEALSNAF-HGEPSGGQWSWGTRLDTEPHDLTNMLVAEVKSRPGNDRCCDCGA 445

  Fly   448 RNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKL 512
            . |.||:|.|.|:|.|||||||||:|||..|||||||||.|..:.||:|..:|||..|::|||.|
Mouse   446 A-DPTWLSTNLGVLTCIQCSGVHRELGVRFSRIQSLTLDLLGPSELLLALNIGNSHFNEVMEAHL 509

  Fly   513 ---GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGA 574
               |..|...||.|..|.::|.||||..::...:..|...||    .|:.:.|:..:|:.:|.|.
Mouse   510 PSHGSPKPSAESDMSSRRNYIVAKYVEHKFARHSTPDPQKLR----TAICSRDLLSVLEAFANGQ 570

  Fly   575 DLTCCLPSSDA---GETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGK--NT 634
            |....||..|.   ||.|||||:.....::|.||||||||            .|.||....  ||
Mouse   571 DFGQLLPGPDGQAPGELALHLAIRVASHASLPIVDFLIQN------------GGHLDAKAADGNT 623

  Fly   635 ALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFD-HI 698
            |||..|||.:.:|:|||||..|.....|...:||||||:...|..|.||:|.| :....||. |:
Mouse   624 ALHCAALHGQLDCLKLLLRGRAPVGAVNDAGETALDIARNRQHKECEELLEQA-QAGTLAFPLHM 687

  Fly   699 NTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSR 763
            :..|....|.|   |..:|...:|:...|:||:.|...|..|...:.|.::: ::..| |...|:
Mouse   688 DYHWGHSMEHG---FDSEEEEEEEKHCPSKPPAQACWGSVRLDISNKTYETV-ATPGP-ATTQSQ 747

  Fly   764 QFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNG---PGNGGSSPSSASSQSVRAARNSL 825
            ....|..|| ..:|:.|.         .||.|.:..|:.   |.....||.:..::|..|:.:|.
Mouse   748 SEDSPPPLP-IKNSSRTI---------VLGRAGHCSGDRSDLPSLRSESPEALENRSSPASSSSS 802

  Fly   826 NMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDI 890
            ...|...|.::.|..|.......|     |....||.....:|:..|  ||      ..|.:...
Mouse   803 LTSSVEPGGLSQAPSSPEEGLQES-----ASISRPGLASGTTSAEVY--LP------VKFSSEST 854

  Fly   891 RAINHKNQSLDVAYGTLPHLRSVESSPRG---GGGYGYGVSQD 930
            |:.....:||:.:......|.|....|.|   |.|...||..|
Mouse   855 RSYRRGGRSLEDSPSARQPLCSRRHIPVGLVEGDGSKIGVLPD 897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsapNP_001014504.1 BAR_ASAPs 35..249 CDD:153288 84/213 (39%)
PH_ASAP 302..410 CDD:270071 55/107 (51%)
ArfGap_ASAP 425..541 CDD:350063 63/118 (53%)
ANKYR <573..709 CDD:440430 57/141 (40%)
ANK repeat 586..622 CDD:293786 16/35 (46%)
ANK repeat 624..662 CDD:293786 18/39 (46%)
Vac17 <706..>788 CDD:435863 20/81 (25%)
SH3_ASAP 1095..1149 CDD:212755
Asap3NP_001008233.1 BAR_ASAP3 35..243 CDD:153324 84/213 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..297 8/23 (35%)
PH_ASAP 294..400 CDD:270071 55/107 (51%)
ArfGap_ASAP3 423..546 CDD:350087 63/123 (51%)
ANK repeat 550..583 CDD:293786 11/36 (31%)
ANK 1 584..616 18/43 (42%)
ANKYR <585..678 CDD:440430 47/105 (45%)
ANK repeat 585..618 CDD:293786 19/44 (43%)
ANK repeat 620..651 CDD:293786 15/30 (50%)
ANK 2 620..649 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 697..716 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..877 35/166 (21%)
Blue background indicates that the domain is not in the aligned region.

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