DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Asap3

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001008233.1	Gene:	Asap3 / 230837	MGIID:	2684986	Length:	904	Species:	Mus musculus

Alignment Length:	953	Identity:	355/953 - (37%)
Similarity:	512/953 - (53%)	Gaps:	82/953 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPT-TSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSG 66
            |..::|:||:..|..|.|||. .:.||::||.||......||.||.|:..|.::||||:|||:||
Mouse     2 PEQLSVAEFLAVTAEDLSSPAGAAAFAAKMPRCRGAALAREEALEGDQAILQRIKKAVRAIHSSG 66

  Fly    67 NTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSM 131
            ..||:.|.....|:|.||...:.|:..::...||..:|.|:|::||.|.|:||:||||.||:||:
Mouse    67 LGHVETEEHYREAVEALGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDSL 131

  Fly   132 LKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQ 196
            :|..||..:.|.|:..:||.||||:|..|:|||:.......|      ...|::::.::|||::|
Mouse   132 MKGHLRDGRHDSKKHLEKAWKDYESKVAKLEKERDRARFPGG------SHGVMSQDTQRERRVFQ 190

  Fly   197 LQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQD 261
            |..||||:|..:.:.|.|.:.||.||:::||..|:|:||.:..:....:|..|:..:|.::|.|:
Mouse   191 LHMCEYLVKAGESQVKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLSPFIDKLAASVHGLRQAQE 255

  Fly   262 EDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVR 326
            |:...|..||..||.....|..::.|:  .::.|.|||:||.||:|..|..:.|.|.|||:| :|
Mouse   256 EELHKLTQLRDSLRGMLHLESREDHPN--RKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDG-IR 317

  Fly   327 RVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGD 391
            ||||||:|.| ..|.|.|.|:..::||.::.|||||::|.|::||.|||:::||.|||.||||.:
Mouse   318 RVWQKRKCGV-KYGCLTISHSMINRPPVKLPLLTCQVRPNPEEKRCFDLVTHNRTYHFHAEDEQE 381

  Fly   392 QKAWMAVLVNCKEKALTKAFQHANP---------QMSPSLVELQKTVIRYVQLLPGNDRCCDCGS 447
            .:||::||.|.|::||:.|| |..|         ::.....:|...::..|:..||||||||||:
Mouse   382 CEAWVSVLQNSKDEALSNAF-HGEPSGGQWSWGTRLDTEPHDLTNMLVAEVKSRPGNDRCCDCGA 445

  Fly   448 RNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKL 512
            . |.||:|.|.|:|.|||||||||:|||..|||||||||.|..:.||:|..:|||..|::|||.|
Mouse   446 A-DPTWLSTNLGVLTCIQCSGVHRELGVRFSRIQSLTLDLLGPSELLLALNIGNSHFNEVMEAHL 509

  Fly   513 ---GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGA 574
               |..|...||.|..|.::|.||||..::...:..|...||    .|:.:.|:..:|:.:|.|.
Mouse   510 PSHGSPKPSAESDMSSRRNYIVAKYVEHKFARHSTPDPQKLR----TAICSRDLLSVLEAFANGQ 570

  Fly   575 DLTCCLPSSDA---GETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGK--NT 634
            |....||..|.   ||.|||||:.....::|.||||||||            .|.||....  ||
Mouse   571 DFGQLLPGPDGQAPGELALHLAIRVASHASLPIVDFLIQN------------GGHLDAKAADGNT 623

  Fly   635 ALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFD-HI 698
            |||..|||.:.:|:|||||..|.....|...:||||||:...|..|.||:|.| :....||. |:
Mouse   624 ALHCAALHGQLDCLKLLLRGRAPVGAVNDAGETALDIARNRQHKECEELLEQA-QAGTLAFPLHM 687

  Fly   699 NTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSR 763
            :..|....|.|   |..:|...:|:...|:||:.|...|..|...:.|.::: ::..| |...|:
Mouse   688 DYHWGHSMEHG---FDSEEEEEEEKHCPSKPPAQACWGSVRLDISNKTYETV-ATPGP-ATTQSQ 747

  Fly   764 QFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNG---PGNGGSSPSSASSQSVRAARNSL 825
            ....|..|| ..:|:.|.         .||.|.:..|:.   |.....||.:..::|..|:.:|.
Mouse   748 SEDSPPPLP-IKNSSRTI---------VLGRAGHCSGDRSDLPSLRSESPEALENRSSPASSSSS 802

  Fly   826 NMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDI 890
            ...|...|.::.|..|.......|     |....||.....:|:..|  ||      ..|.:...
Mouse   803 LTSSVEPGGLSQAPSSPEEGLQES-----ASISRPGLASGTTSAEVY--LP------VKFSSEST 854

  Fly   891 RAINHKNQSLDVAYGTLPHLRSVESSPRG---GGGYGYGVSQD 930
            |:.....:||:.:......|.|....|.|   |.|...||..|
Mouse   855 RSYRRGGRSLEDSPSARQPLCSRRHIPVGLVEGDGSKIGVLPD 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	84/213 (39%)
		PH_ASAP	302..410	CDD:270071	55/107 (51%)
		ArfGap_ASAP	425..541	CDD:350063	63/118 (53%)
		Ank_2	554..662	CDD:403870	43/112 (38%)
		ANK repeat	586..622	CDD:293786	16/35 (46%)
		ANK repeat	624..662	CDD:293786	18/39 (46%)
		Ank_2	636..>693	CDD:403870	25/56 (45%)
		SH3_ASAP	1095..1149	CDD:212755
Asap3	NP_001008233.1	BAR_ASAP3	35..243	CDD:153324	84/213 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..297		8/23 (35%)
		PH_ASAP	294..400	CDD:270071	55/107 (51%)
		PH	307..390	CDD:278594	45/84 (54%)
		ArfGap	427..541	CDD:279720	62/114 (54%)
		ANK repeat	550..583	CDD:293786	11/36 (31%)
		ANK 1	584..616		18/43 (42%)
		ANK	<585..673	CDD:238125	44/99 (44%)
		ANK repeat	585..618	CDD:293786	19/44 (43%)
		Ank_4	588..641	CDD:290365	28/64 (44%)
		ANK repeat	620..651	CDD:293786	15/30 (50%)
		ANK 2	620..649		15/28 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..716		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..877		35/166 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5557
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43449
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780