DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Asap and Git1

DIOPT Version :10

Sequence 1:NP_001014504.1 Gene:Asap / 35783 FlyBaseID:FBgn0050372 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001004144.1 Gene:Git1 / 216963 MGIID:1927140 Length:770 Species:Mus musculus


Alignment Length:726 Identity:150/726 - (20%)
Similarity:253/726 - (34%) Gaps:194/726 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   437 PGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGN 501
            |..:.|.|| |..|..|.|::.|:|||.:|..|||.||.|.|.::.|.........|.:...:.:
Mouse     6 PRAEVCADC-SAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69

  Fly   502 STLNDIMEAKL--------GRGKLQHESSMEE-RYDFIRAKYVAKRYVMR-TCSDDNDLRCDLEQ 556
            :..|.|.|..|        ||.|...:..:.. :.:||||||....:|.: .|.||:        
Mouse    70 NGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDD-------- 126

  Fly   557 AVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKAT 621
            .|...|:|:.|.......:|          ||.|.|..|....:..|         |.||     
Mouse   127 GVTAKDLSKQLHSSVRTGNL----------ETCLRLLSLGAQANFFH---------PEKG----- 167

  Fly   622 NPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRE-LIE 685
                       .|.||:.|...:....:||:..|||....:...:|.:|.|::.||:...| |:|
Mouse   168 -----------TTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221

  Fly   686 CAIK-REKSAF-------DHINTDWNLPN-----------------------------------E 707
            |..: .::.||       ||.|..:.:|.                                   |
Mouse   222 CQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFE 286

  Fly   708 DGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSGLP 772
            :.:.|..|:   :|.|::          |:..|.:::.:....:.|:.|.         ||.. |
Mouse   287 ELAMDVYDE---VDRREN----------DAVWLATQNHSTLVTERSAVPF---------LPVN-P 328

  Fly   773 SY--THSAGTSPKQHISVGQY----LGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDL 831
            .|  |.:.|.......:..::    :...:.......|...|||:.....|.| :::.|:.|.|.
Mouse   329 EYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSAR-SQSELDDQHDY 392

  Fly   832 GGHVT------------GARKSTSTANMNS---------------LKKRTAPAPPPGTLGSASSS 869
            ....:            ||.::....:|:|               |||..|.:..........:|
Mouse   393 DSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNS 457

  Fly   870 SFYGTLPHPPRHSQNFDASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGG------------ 922
            |....|....|......|.:::.   :.....|...:||..|: |.:..|.||            
Mouse   458 SLSDELRRLQREIHKLQAENLQL---RQPPGPVPPPSLPSERA-EHTLMGPGGSTHRRDRQAFSM 518

  Fly   923 YGYGVSQDPGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHL-AGAKLV--------LPPTGE 978
            |..|.:..|.|...|  :.|...:..| |......::: .::|: ||...:        :|.|..
Mouse   519 YEPGSALKPFGGTPG--DELATRLQPF-HSTELEDDAI-YSVHVPAGLYRIRKGVSASSVPFTPS 579

  Fly   979 LPTLKHVDKSALTRPKIPPPGPPSEREISNGQSNESISSMDEGPVAPPRKLVNQSANFPDYESWH 1043
            .|.|....:.:....|:...|..::.:..|.||.:.:..: ||     ::.:..|..    :..|
Mouse   580 SPLLSCSQEGSRHASKLSRHGSGADSDYENTQSGDPLLGL-EG-----KRFLELSKE----DELH 634

  Fly  1044 TDMDSSGGGLD 1054
            .:::|..|.||
Mouse   635 PELESLDGDLD 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsapNP_001014504.1 BAR_ASAPs 35..249 CDD:153288
PH_ASAP 302..410 CDD:270071
ArfGap_ASAP 425..541 CDD:350063 35/112 (31%)
ANKYR <573..709 CDD:440430 35/179 (20%)
ANK repeat 586..622 CDD:293786 9/35 (26%)
ANK repeat 624..662 CDD:293786 9/37 (24%)
Vac17 <706..>788 CDD:435863 15/118 (13%)
SH3_ASAP 1095..1149 CDD:212755
Git1NP_001004144.1 Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 1..124 37/118 (31%)
ArfGap_GIT1 1..111 CDD:350071 33/105 (31%)
ANKYR <123..221 CDD:440430 32/140 (23%)
ANK 1 132..161 9/38 (24%)
ANK repeat 137..165 CDD:293786 8/46 (17%)
ANK 2 166..195 11/44 (25%)
ANK repeat 167..197 CDD:293786 10/45 (22%)
ANK 3 199..228 9/28 (32%)
Interaction with PCLO. /evidence=ECO:0000250|UniProtKB:Q9Z272 245..374 20/151 (13%)
Interaction with PTK2/FAK1. /evidence=ECO:0000250|UniProtKB:Q9Z272 253..424 28/194 (14%)
Interaction with ARHGEF7. /evidence=ECO:0000250|UniProtKB:Q9Z272 254..376 19/144 (13%)
GIT_SHD <281..301 CDD:462506 5/22 (23%)
GIT_SHD 337..365 CDD:462506 1/27 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..425 13/62 (21%)
Interaction with NCK2 and GRIN3A. /evidence=ECO:0000250|UniProtKB:Q9Z272 375..596 41/229 (18%)
Required for localization at synapses. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 375..596 41/229 (18%)
GIT_CC 418..482 CDD:465174 11/66 (17%)
Interaction with MAPK1. /evidence=ECO:0000269|PubMed:15923189 420..475 10/54 (19%)
Interaction with IKBKG. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 429..629 39/213 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..615 7/36 (19%)
Interaction with PXN and TGFB1I1. /evidence=ECO:0000250|UniProtKB:Q9Z272 646..770 150/726 (21%)
GIT1_C 652..765 CDD:463492
Blue background indicates that the domain is not in the aligned region.

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