DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Asap and Acap1

DIOPT Version :9

Sequence 1:NP_001014504.1 Gene:Asap / 35783 FlyBaseID:FBgn0050372 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_722483.2 Gene:Acap1 / 216859 MGIID:2388270 Length:740 Species:Mus musculus


Alignment Length:811 Identity:193/811 - (23%)
Similarity:313/811 - (38%) Gaps:207/811 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 IGVLEERLEFDREGLTKLKKAVKAIHNSGNTHV-DNEMFMVRA--LERLGGKVIEQDEPDIGAAF 99
            :..||.|||       ||.|....:..||..:: ....|:|..  |.|||     ..||.:....
Mouse    28 VSELETRLE-------KLLKLGSCLLESGQHYLAAGRAFVVGICDLARLG-----PPEPMMAECL 80

  Fly   100 LKFSVVTKE--------LSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFDKAAKDYEA 156
            .||:|....        |.|...||.|.|..:|        |..|||.: :.:|.|.:.|::.||
Mouse    81 EKFTVSLNHKLDSHAELLDATQHTLQQQIQTLV--------KEGLRGFR-EARRDFWRGAENLEA 136

  Fly   157 KF---IKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIKTKTGIELL 218
            ..   .::.:.:..:|:|||..            :...|..|:.:..:|.|:...|:.|...:::
Mouse   137 ALTHNAEVPRRRVQEAEEAGTA------------LRTARAGYRSRALDYALQVNVIEDKRKFDIM 189

  Fly   219 QHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEI-----KQKQD-EDRRSLLDLRTVLRST 277
            :.::....|.:.||:.|.:.:.....|..:|..:||.:     :||:| |.|..||..:.:....
Mouse   190 EFVLRLVEAQATYFQQGHEELNRLAQYRKELGTQLHNLVLNSARQKRDMEQRHVLLKQKELGGEE 254

  Fly   278 PDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGFL 342
            |:       ||.:             :|..  |:..:|||.|::.... :.|.:|...:.::   
Mouse   255 PE-------PSLK-------------EGPS--GLVMEGHLFKRASNAF-KTWSRRWFTIQNN--- 293

  Fly   343 DIFHADESKPPTRV---NLLTCQIKPVPDDKRG--FDLISYNRPYHFQAEDEGDQKAWMAVLVNC 402
            .:.:..:.|.|..|   :|..|.:|..||.:|.  |:::|.::....||:.|...:.|    |:.
Mouse   294 QLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCFLQADSERLLQLW----VSA 354

  Fly   403 KEKALTKAFQHANPQMSP-------------SLVELQ-------------KTVIRYVQLLPGNDR 441
            .:.::..||..|:.:.||             |...|.             ..|...||.:.||.:
Mouse   355 VQSSIASAFSQAHLENSPRGPGQVSGYHAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQ 419

  Fly   442 CCDCGSRNDV-TWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLN 505
            ||||  |... .|.|:|.|:.:||||||:||.||||.|:::|||||:.....:.:...:||..:|
Mouse   420 CCDC--REPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIIN 482

  Fly   506 DIMEAK---LGRGKLQHESSMEERYDFIRAKYVAKRYVMR------------------------- 542
            .|.||:   :...|.....|.:|:..:|.||||.|:::.:                         
Mouse   483 QIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPP 547

  Fly   543 ------------TCSDDNDLRCDLEQAVVNADMSQ----------LLQVWAEGADLTCCLPSSDA 585
                        .|..|     |:......|.:.|          :....|.|||:...    :.
Mouse   548 IRPHSGIVRSKSECPSD-----DMGSLHPGALLFQAAGHPPSLPTMADALAHGADVNWV----NV 603

  Fly   586 GETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCAL-HDRRECMK 649
            |:......:.....::|...:||:||    |.|  .|.|   |..|:....|...| |....|  
Mouse   604 GQGNATPLIRATAANSLLACEFLLQN----GAN--VNQA---DSAGRGPLHHATILGHTGLAC-- 657

  Fly   650 LLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFS 714
            |.|:.|||...::::.:..|.||.|..:.....|:..|..||..|               :...:
Mouse   658 LFLKRGADLGARDTEGRDPLTIAMETTNADIVTLLRLAKMREAEA---------------AQGQA 707

  Fly   715 DDETVIDERKSRSRPPSFAGGDSPVLRSRSS 745
            .|||.:|    ..|..|....|.|...||.|
Mouse   708 GDETYLD----IFRDFSLMASDDPEKLSRRS 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsapNP_001014504.1 BAR_ASAPs 35..249 CDD:153288 52/224 (23%)
PH_ASAP 302..410 CDD:270071 24/112 (21%)
ArfGap_ASAP 425..541 CDD:350063 48/132 (36%)
Ank_2 554..662 CDD:403870 27/118 (23%)
ANK repeat 586..622 CDD:293786 8/35 (23%)
ANK repeat 624..662 CDD:293786 12/38 (32%)
Ank_2 636..>693 CDD:403870 17/57 (30%)
SH3_ASAP 1095..1149 CDD:212755
Acap1NP_722483.2 Required for formation of endosomal tubules when overexpressed with PIP5K1C. /evidence=ECO:0000250|UniProtKB:Q15027 1..382 94/416 (23%)
BAR_ACAP1 18..217 CDD:153323 51/221 (23%)
PH 266..360 CDD:278594 22/101 (22%)
PH_ACAP 268..364 CDD:270070 23/103 (22%)
Required for interaction with GULP1. /evidence=ECO:0000250|UniProtKB:Q15027 405..740 97/371 (26%)
ArfGap 406..519 CDD:279720 47/114 (41%)
Prevents interaction with ITGB1 when S-554 is not phosphorylated. /evidence=ECO:0000250 525..566 2/45 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..562 0/36 (0%)
Ank_2 575..670 CDD:289560 26/109 (24%)
ANK repeat 575..602 CDD:293786 5/30 (17%)
ANK <592..692 CDD:238125 29/114 (25%)
ANK repeat 606..637 CDD:293786 9/39 (23%)
ANK repeat 639..670 CDD:293786 10/32 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D751525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.