DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and Appl2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_660255.1	Gene:	Appl2 / 216190	MGIID:	2384914	Length:	662	Species:	Mus musculus

Alignment Length:	464	Identity:	98/464 - (21%)
Similarity:	188/464 - (40%)	Gaps:	110/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PDCRHTIGVLEERLEFDREGLT----KLKKAVKAIHNSGNTHVDNEMFMVRALERLGGKVIEQD- 91
            |..|..:.|.||    |...||    :|.:|::.::.:     .|||.:  |.::|..:::..:
Mouse    17 PQARSLLSVFEE----DAGTLTDYTNQLLQAMQRVYGA-----QNEMCL--ATQQLSRQLLAYEK 70

  Fly    92 --------EPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFD 148
                    :.::.:....||.|..||:.|...|.:.:.:.::.||....:.:|..| ..:|..|.
Mouse    71 QNFALGKGDEEVISTLHYFSKVMDELNGLHTELAKQLADTMVLPVIQFREKDLTEV-STLKDLFG 134

  Fly   149 KAAKDYE---AKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIK 210
            .|:.:::   ||:.::.|:     ||....:|||     .:|:...||...|.:.:|......::
Mouse   135 LASSEHDLSMAKYSRLPKK-----KENEKAKTEI-----VKEVAAARRKQHLSSLQYYCALNALQ 189

  Fly   211 TKTGIELLQHLIEYYHALSNYFKDGLQ----TIEHFGTYIGDLSEKLH-EIKQKQDEDRRSLLDL 270
            .:....:::.||.:.|...|:||.|.:    :::.|.:.:.|:.:.:. |::.:.|:.|.|..:|
Mouse   190 YRKRAAMMEPLIGFAHGQINFFKRGAEMFSKSMDGFLSSVKDMVQSIQVELEAEADKMRVSQQEL 254

  Fly   271 RTVLRS--TPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHL-LKKSEGKVRRVWQKR 332
            .:|..|  |||   :|...:..:|                :.:.:.|:| |:...|.|...|: |
Mouse   255 LSVSESVYTPD---IDVATAQINR----------------NLIQKTGYLNLRNKTGLVTTTWE-R 299

  Fly   333 RCRVTSDGFLDIFHADESKPPTRV------NLLTCQIKPV-------------PDDKRGFDLISY 378
            ....|..|.|      ..:|...|      :|..|.:..|             |..|.|..|
Mouse   300 LYFFTQGGNL------MCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQISTPSGKPGIIL--- 355

  Fly   379 NRPYHFQAEDEGDQKAWMAVLVNCKEKA-LTKAFQHANPQMSPSLVELQKTVIRYVQLLP--GND 440
                  |||...:.:.|:..:.|...:. ||.     ||:  ...::|.:|.::.|..:.  |..
Mouse   356 ------QAESRKEYEEWICAVNNISRQIYLTD-----NPE--AVAIKLNQTALQAVTPITSFGKK 407

  Fly   441 RCCDCGSRN 449
            :...|.|:|
Mouse   408 QESSCSSQN 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	49/233 (21%)
		PH_ASAP	302..410	CDD:270071	26/128 (20%)
		ArfGap_ASAP	425..541	CDD:350063	7/27 (26%)
		Ank_2	554..662	CDD:403870
		ANK repeat	586..622	CDD:293786
		ANK repeat	624..662	CDD:293786
		Ank_2	636..>693	CDD:403870
		SH3_ASAP	1095..1149	CDD:212755
Appl2	NP_660255.1	BAR_APPL2	20..234	CDD:153316	50/235 (21%)
		BAR-PH_APPL	252..376	CDD:270067	32/158 (20%)
		PH	278..378	CDD:278594	24/115 (21%)
		PH domain	278..376		24/113 (21%)
		PTB_APPL	480..613	CDD:269980
		PTB domain	491..607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810