DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and Arap2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_848494.2	Gene:	Arap2 / 212285	MGIID:	2684416	Length:	1703	Species:	Mus musculus

Alignment Length:	486	Identity:	106/486 - (21%)
Similarity:	182/486 - (37%)	Gaps:	145/486 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 EIKQKQDEDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGA---------GYSLHQLQGDKHHG 310
            |.|....:|..|..:..||........| .|..:|:||:..|         .|.|....|:....
Mouse   398 EDKNNLAQDSASESEYSTVEECFQSLRR-KNSKASKSRTQKAFYLDPFNRHSYPLSSTSGNTEPS 461

  Fly   311 VT-------------------RQGHLLKKS-EGKVRRVWQKRRCRVTSDGF-LDIFHADE---SK 351
            .|                   :.|.|.|.| :||  |::|||  .|..||. :..::.|.   ||
Mouse   462 STISNAISPYACFYGSSAAKEKCGWLDKLSPQGK--RMFQKR--WVKFDGLSISYYNNDREMYSK 522

  Fly   352 ---PPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGDQKAWMAVLVN------------ 401
               |.|.::.:..|    .|:|  |::::..|.:.|:.|.|.::..|:::|::
Mouse   523 GIIPLTAISTVRAQ----GDNK--FEIVTTQRTFVFRVEKEEERNDWISILLSALKSPSLASQLQ 581

  Fly   402 -------------------------------CK------------------------EKALTKAF 411
                                           ||                        ::|:.::|
Mouse   582 AAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRAVKQSF 646

  Fly   412 QHANPQMSPSLV----------------ELQKTVIRY-----VQLLPGNDRCCDCGSRNDVTWIS 455
            :...|..|.|..                .:.:|:..|     :.....|..|.|| ...|..|.|
Mouse   647 EIITPYRSFSFTADSEREKQEWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADC-KAPDPDWAS 710

  Fly   456 LNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIAR--AMGNSTLNDIMEAKLGRG-KL 517
            :|..:::|.:|:|.||.||...|:::||.:|....:|.||..  .:||...||.....|.:. :|
Mouse   711 INLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEEL 775

  Fly   518 QHESSMEERYDFIRAKYVAKRY--VMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCL 580
            |.:|.:|:|.:||..||...::  .:.......:|...|..|||..|:.:.:.:...|||:.|.
Mouse   776 QVDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCA- 839

  Fly   581 PSSDAGETALHLAVLREMGSTLHIVDFLIQN 611
             :.|...:..:| :.::.|.:|. ::||..|
Mouse   840 -TGDPVHSTPYL-LAKKAGQSLQ-MEFLYHN 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	33/201 (16%)
		ArfGap_ASAP	425..541	CDD:350063	38/125 (30%)
		Ank_2	554..662	CDD:403870	16/58 (28%)
		ANK repeat	586..622	CDD:293786	6/26 (23%)
		ANK repeat	624..662	CDD:293786
		Ank_2	636..>693	CDD:403870
		SH3_ASAP	1095..1149	CDD:212755
Arap2	NP_848494.2	SAM_Arap1,2,3	6..68	CDD:188889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..232
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319
		PH1_ARAP	482..573	CDD:270073	28/100 (28%)
		PH2_ARAP	583..673	CDD:270074	7/89 (8%)
		ArfGap_ARAP2	678..798	CDD:350081	38/120 (32%)
		PH3_ARAP	890..1000	CDD:270076
		PH-like	1013..1108	CDD:388408
		RhoGAP_ARAP	1112..1291	CDD:239850
		RA_ARAP2	1323..1420	CDD:340747
		PH-like	1426..1537	CDD:388408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1633..1670
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1684..1703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810