DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and git-1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_509761.2	Gene:	git-1 / 181253	WormBaseID:	WBGene00008805	Length:	670	Species:	Caenorhabditis elegans

Alignment Length:	722	Identity:	131/722 - (18%)
Similarity:	226/722 - (31%)	Gaps:	263/722 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 CCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLND 506
            |.||| :.:|.|.|:..|.::|.:|...|..||...|.::.|........::.:..|:..|..|.
Worm    18 CDDCG-KKEVEWASVKKGTVICSECFCFHSYLGPSVSYLRHLRKSAWDEEHIRLVHALNTSNTNM 81

  Fly   507 IMEAKLGRGKLQHESSMEERYDFIRAKYVAKRYVMRTC----SDDNDLRCDLEQ---AVVNADMS 564
            |.|:.|..|..:.:..|.:....|:.::|.::|...|.    ..|.||...|.:   |...:|.:
Worm    82 IWESALYEGSTKFQKPMAQDPSHIKEQFVKEKYEKLTFQPKRGKDEDLENSLNRQLIACARSDFA 146

  Fly   565 QL-LQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD 628
            .: |::.|.|||:.  .|..:.|:||||:|. ||..|..
Worm   147 HVTLRLIALGADVN--YPDPETGDTALHVAA-REGNSNQ-------------------------- 182

  Fly   629 VTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELI--------- 684
                               ::||...|||....|.:......:|::.||......|
Worm   183 -------------------VELLFLYGADIMAPNREGMLPYILARDAGHGQLSHRIYEFFFYVFD 228

  Fly   685 -----ECAIKREKSAFDHINT-DWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSR 743
                 .|..|.     ||.|. |:.:|.             :.|::..::
Worm   229 RFSFFMCNRKA-----DHKNNQDFFIPE-------------VTEKQFLTK--------------- 260

  Fly   744 SSTCDSIQSSSSPIANCPSRQFTLPSGL------PSYTHSAGTSPKQHISVGQYLGSATNVGGNG 802
              |.||..:.|           .||.|.      .::..:.....:.:.::.::..:|     .|
Worm   261 --TNDSRAAIS-----------VLPKGQFFDLCEDAFDETVRRENEVNWNMTKWAKTA-----KG 307

  Fly   803 PGNGGSSPSSASSQSVRAARNS-----------------LNMQSDLGGHVTGARKSTSTANMNSL 850
            |.|....|:...|    ||||.                 :::..|....:||..
Worm   308 PTNLFLPPTPQMS----AARNQRRQKLAKFTPIQFTILLIDLIKDQKRRITGDN----------- 357

  Fly   851 KKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDIRAINHKNQSLDVAYGTLPHLRSVES 915
                 |||                :..||::.:..:.:.:| |..|::     |.....:..:..
Worm   358 -----PAP----------------VSEPPKNMRKSNDTPLR-IMKKSE-----YADYDEVAGISC 395

  Fly   916 SPRGGGGYGYGVSQDPGGSGN--------------------GSNNSLMPAMTTFGHKRSPSGESL 960
            ||..|        ..|....|                    .|..:::..:|       ...|.|
Worm   396 SPISG--------IVPNSQANTLDESSSRVWDELLEMKERLSSTETMVVTLT-------KQNEEL 445

  Fly   961 NRNIHLAGAKLVLPPTGELPT----LKHVDKSALTRPKIPPPGPPSEREISNGQSNESISSMDEG 1021
            .:.:|...|:.: ....||.|    |.::.::.:|| ::|.|                 .::.|.
Worm   446 TKLVHSLQAQNI-NLNSELITFRDDLYNLKRTNMTR-RMPSP-----------------LAIVET 491

  Fly  1022 P--VAPPRKLVNQSANFPDYES--------WHTDMDSSGGGLDHSAESNVSSSDNDRLNS----- 1071
            |  |.||.. :.|..:..|.|.        |.::........||..:..|....:..:.|
Worm   492 PERVMPPVG-IQQGFSRRDSEDRIDGGGARWRSNSSDRRNSNDHKLDKKVERRQDSMMESSSSLS 555

  Fly  1072 -SPDNPS 1077
             |..|||
Worm   556 RSSQNPS 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	26/98 (27%)
		Ank_2	554..662	CDD:403870	23/111 (21%)
		ANK repeat	586..622	CDD:293786	9/35 (26%)
		ANK repeat	624..662	CDD:293786	5/37 (14%)
		Ank_2	636..>693	CDD:403870	12/70 (17%)
		SH3_ASAP	1095..1149	CDD:212755
git-1	NP_509761.2	ArfGap	7..127	CDD:214518	27/109 (25%)
		ANK	<122..212	CDD:238125	28/137 (20%)
		Ank_5	152..207	CDD:290568	20/102 (20%)
		ANK repeat	165..197	CDD:293786	14/77 (18%)
		GIT	264..294	CDD:128828	5/40 (13%)
		GIT	326..356	CDD:128828	2/29 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810