DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and cnt-1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001369802.1	Gene:	cnt-1 / 174848	WormBaseID:	WBGene00000565	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	865	Identity:	179/865 - (20%)
Similarity:	302/865 - (34%)	Gaps:	237/865 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TTSTFASRMP------DCRHTI--------GVLEERLEFDR--EGLTKLKKAVKAIHNSGNTHVD 71
            |.|.....||      ||...|        .|.:..:.|:|  ..|.::.:.:.|:.:....:.:
Worm     2 TVSNNGMAMPSVPPKIDCSEAIQDSPKFRATVAQHAMYFNRLENRLNEMLRHITAMIDFSKNYTN 66

  Fly    72 NEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSEL 136
            ....:..::.:|..:.. ...|.....|...|........|.:|...:.|.:....:.:.:|.||
Worm    67 TFYKLTVSVNQLCDESF-SGNPLASTTFQGLSEAYAHTVNLFRTYFDHSNVVTFTKLSNFIKIEL 130

  Fly   137 RGVKGDMKRPFDKAAKDYEAKFIK---IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQ 198
            ..| .:.:..|:..::..:...:|   |.::|.|.|.|.....|.:...            :...
Worm   131 TKV-AESRAHFENMSQSMDDALVKNASISRQKPADATEGRNALTAVGTC------------FAHT 182

  Fly   199 TCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHF-GTYIGDLSEKLHEIKQKQDE 262
            |.:|:.............:|..|.......|.:|..|..|.:.: ....|.:::.:.....|...
Worm   183 TLDYVANINIAHAHKDHMILDALWTLVRESSAFFSKGHATFDEWTAADNGAIADTIQTFAAKSKL 247

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRR 327
            ..|.:.|:.:::.... |:....:|               ::.|    |..:|:|.|:|.... :
Worm   248 IERKMQDVHSLVPKEM-FQHPSGMP---------------IEPD----VMMEGYLYKRSSNAF-K 291

  Fly   328 VWQKRRCRVTSDGFLDIFHADESKPPT--RVNLLTCQIKPVPD--DKRG-FDLISYNRPYHFQAE 387
            .|.:|..::.....|....:.:.:|.|  ..||..|.::|.|.  |:.| |:|::..|.:..||:
Worm   292 TWNRRWFQIKDKQLLYSHRSTDLEPATIMEENLRICLVRPAPSNIDRIGCFELVTPTRIHLLQAD 356

  Fly   388 DEGDQKAWMAVL-----------------VNCKEKA-----------------------LTKAFQ 412
            .|...:.||..|                 .:.:.|.                       :||...
Worm   357 SESLCQDWMRALQRTILALHEGDSVDVASTSPRNKTTSMSSGVTLTSANAISPLSNAMDVTKGRS 421

  Fly   413 HANPQMSPSLVELQK-----------TVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQC 466
            .::|..:.:......           |....|:.:|||:.|.||||... .|:|:|.|:::||:|
Worm   422 VSDPASTYTSANTSSISTAAGFSSSTTAFEQVRRVPGNEVCADCGSPAP-KWVSINLGVVLCIEC 485

  Fly   467 SGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRG------KLQHESSMEE 525
            ||.||.|||..|:::||.:|::......:..|:||..:|:|..|.|...      ::..:|:...
Worm   486 SGAHRSLGVQTSKVRSLCMDSIDNELRDVLLALGNRQVNEIFLAHLPPADSIVPPQINEKSARPA 550

  Fly   526 RYDFIRAKYVAKRYV-------------------------------------------------- 540
            |..:|:||||.:|:.
Worm   551 REAWIKAKYVERRFAVAEDTRARSSATNRQEHLKHKTSIGGNSSSNGVNRSSSYADVQDAESGGL 615

  Fly   541 --------------------MRTCSDDNDLRC--------------DLEQAVVNADMSQLLQVWA 571
                                :..|..|.:|..              .:::|....|:..|:..:|
Worm   616 LDADPWSADLSVPVPTASKRLSACGSDTNLDAIGSSSIDTKTVEWDSVKEACECGDLLALMTAYA 680

  Fly   572 EGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTAL 636
            :|.||.    :...|.||||:|.  ..|.|. .|:||:       ||.|  ...:|| ...||.|
Worm   681 QGFDLN----ALHNGTTALHIAT--RNGQTA-AVEFLL-------LNGA--KINMLD-EKLNTPL 728

  Fly   637 HLCAL--HDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHIN 699
            ||.|.  |....|.  ||:.|||..|.|..:||.||||.|..|.....|....|.|     :..|
Worm   729 HLAAKEGHTLPVCQ--LLKRGADSNLANVDSKTPLDIAMECTHADIVTLFRVTIMR-----NDFN 786

  Fly   700 TDWNLPNEDGSTDFSDDETV 719
            .|:|.|.         ||||
Worm   787 ADFNNPM---------DETV 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	34/227 (15%)
		PH_ASAP	302..410	CDD:270071	29/152 (19%)
		ArfGap_ASAP	425..541	CDD:350063	43/202 (21%)
		Ank_2	554..662	CDD:403870	37/109 (34%)
		ANK repeat	586..622	CDD:293786	14/35 (40%)
		ANK repeat	624..662	CDD:293786	16/39 (41%)
		Ank_2	636..>693	CDD:403870	24/58 (41%)
		SH3_ASAP	1095..1149	CDD:212755
cnt-1	NP_001369802.1	BAR_ACAPs	30..233	CDD:153287	32/216 (15%)
		PH_ACAP	278..377	CDD:270070	25/99 (25%)
		ArfGap_ACAP	447..565	CDD:350064	43/118 (36%)
		PTZ00322	628..>795	CDD:140343	56/199 (28%)
		ANK repeat	690..721	CDD:293786	14/42 (33%)
		Ank_2	695..775	CDD:403870	36/94 (38%)
		ANK repeat	723..754	CDD:293786	14/32 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920