DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and K02B12.7

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_492310.1	Gene:	K02B12.7 / 172643	WormBaseID:	WBGene00010500	Length:	423	Species:	Caenorhabditis elegans

Alignment Length:	647	Identity:	120/647 - (18%)
Similarity:	205/647 - (31%)	Gaps:	266/647 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 KTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTA 491
            :.|::.::....|:.|.:| ..|:..|:|:::||.:|::|||:||.||||.|.::|:|:|.....
Worm     7 RRVLKELRPCDDNNFCFEC-EANNPQWVSVSYGIWICLECSGIHRSLGVHLSFVRSVTMDKWKDI 70

  Fly   492 NLLIARAMGNSTLNDIMEAKLGRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDND-LRCDLE 555
            .|...:|.||....:.         ||.:...:|::.      :.::|..|..:...| :.|:.|
Worm    71 ELAKMKAGGNRKFAEF---------LQSQPDYKEKWT------IQEKYNSRAAALFRDKVACEAE 120

  Fly   556 QAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPK--GLN 618
            .           :.|::...     |:::                          .:||.  |::
Worm   121 G-----------REWSQSTS-----PAAN--------------------------YVPPTLGGMS 143

  Fly   619 KATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCREL 683
            ..:.|..                                   |:|.|.:       :|
Worm   144 SQSKPTN-----------------------------------KSSGNSS-------LG------- 159

  Fly   684 IECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCD 748
                                                           |:.||:|...:|......
Worm   160 -----------------------------------------------SYYGGNSSYSQSTGDGAY 177

  Fly   749 SIQSSSSPIANCPSRQFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSA 813
            |.|.|:|....               ..:.|..|.|..|....|..|.    :|...|.|..|..
Worm   178 STQDSNSKYQG---------------FGNTGYVPNQSNSGDDLLAGAM----SGLSMGWSMLSKG 223

  Fly   814 SSQSVRAARNSLNMQSDLG--GHVTGARKSTSTANMNSLKKRTA-PAPPPGTLGSASSSSFYGTL 875
            :||:...|:       |:|  .....::.|.:.:..|||....| .|...||......|||.
Worm   224 ASQAAAMAK-------DVGIQAQQKASQLSENVSQNNSLFGGVANKASEVGTKSWDGLSSFV--- 278

  Fly   876 PHPPRHSQNFDASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNN 940
                                |:.||:...|.|  .::......||||         |.||:.|.|
Worm   279 --------------------KSPSLNAFSGIL--AKTGYEDFGGGGG---------GMSGSSSQN 312

  Fly   941 --------SLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRPKIPP 997
                    |.:|..||.|      |:      ||:..:  |.||..:.|.|..::|      :.|
Worm   313 EFNDWLKQSNLPRGTTEG------GD------HLSNEE--LKPTEPVETKKKKERS------VKP 357

  Fly   998 PGPPSEREISNGQSNESISSMDE---------------GPV--APPRKLVNQSANFPDYESW 1042
            .....:....|.:.::|.|::.:               .||  |||:|...::..:.| ::|
Worm   358 VQSKEKVTAENVEDDDSSSTITQFESSFNKPKTTAPRLAPVAAAPPKKKEEKAKGWDD-DAW 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	31/113 (27%)
		Ank_2	554..662	CDD:403870	7/109 (6%)
		ANK repeat	586..622	CDD:293786	3/37 (8%)
		ANK repeat	624..662	CDD:293786	0/37 (0%)
		Ank_2	636..>693	CDD:403870	4/56 (7%)
		SH3_ASAP	1095..1149	CDD:212755
K02B12.7	NP_492310.1	ArfGap_ArfGap1	6..121	CDD:350059	34/129 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810