DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and Agfg1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006496493.1	Gene:	Agfg1 / 15463	MGIID:	1333754	Length:	577	Species:	Mus musculus

Alignment Length:	655	Identity:	144/655 - (21%)
Similarity:	219/655 - (33%)	Gaps:	185/655 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 VIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANL 493
            ::|.:..||.|.:|.||..|.. |::::..|..||..|||..|.|...| |::|:::...|...:
Mouse    16 MLRDMTGLPHNRKCFDCDQRGP-TYVNMTVGSFVCTSCSGSLRGLNPPH-RVKSISMTTFTQQEI 78

  Fly   494 LIARAMGNSTLNDIMEAKLGRGKLQHESSM-------EERYDFIRAKYVAKRYVMRTCSDDNDLR 551
            ...:..||.....|.     .|.....||.       ::..:|::.||..||:.:..
Mouse    79 EFLQKHGNEVCKQIW-----LGLFDDRSSAIPDFRDPQKVKEFLQEKYEKKRWYVPP-------- 130

  Fly   552 CDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKG 616
               |||.|.|.:.  ..:....|..|...|     |.....::|.|....||
Mouse   131 ---EQAKVVASVH--ASISGSSASSTSSTP-----EVKPLKSLLGESAPALH------------- 172

  Fly   617 LNKAT---NPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHN 678
            |||.|   :|     |.|::..                          ..|.|...|:..::|.:
Mouse   173 LNKGTPSQSP-----VVGRSQG--------------------------QQQEKKQFDLLSDLGSD 206

  Fly   679 SCRELIECAIKREKSA------FDHINTD--WNLPNED-----------GSTDFSDDETVIDERK 724
                 |..|...:.:|      |.|.|:.  .|..|.|           ||::|....|.    .
Mouse   207 -----IFAAPAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTA----S 262

  Fly   725 SRSRPPSFAGGDSPVLRSRSSTCDSIQSSSS------------PIANCPSRQFTLPSGLPSYTHS 777
            ..|..|...||.:..:.:..:..|:...|||            ..|:..|:..|..:||.:....
Mouse   263 HSSFQPQTTGGSAGSVNANFAHFDNFPKSSSADFGTFSTSQSHQTASTVSKVSTNKAGLQTADKY 327

  Fly   778 AGTSPKQHI-SVGQYLGSATNVGGNGPGNGGS-----SPSSASSQSVRAARNSLNMQSDLGGHVT 836
            |..:...:| |.||.....:..|..|....||     |.|||||....|.   ..:.|......|
Mouse   328 AALANLDNIFSAGQGGDQGSGFGTTGKAPVGSVVSVPSHSSASSDKYAAL---AELDSVFSSAAT 389

  Fly   837 GARKSTSTANMNS---------LKKRTAPAPP-PGTLGSASSSSFYGTLPHP------------- 878
            .:...|.|:|.:|         ...:|.||.. |...|:..|::.:.....|
Mouse   390 SSNAYTPTSNASSSVFGTVPVGASAQTQPASSGPAPFGATPSTNPFVAATGPSAASSTNPFQTNA 454

  Fly   879 --------PRHSQNFDASDIRA-INHKNQSLDVAYGTLPHLRSVESSPRGG---------GGYGY 925
                    ..|||.|..:...| ....:.|:...:|| |...|:.:|..|.         ..:..
Mouse   455 RGATGLSGAMHSQVFPHAHFAATFGTASMSMPAGFGT-PAQYSLPTSFSGSFQQPAFPAQAAFPQ 518

  Fly   926 --GVSQDPGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKS 988
              ..||.|.|:|..:.....|.:|.||   ..:...::.|..:.||     |||:|||     .|
Mouse   519 QTAFSQQPNGAGFATFGQTKPVVTPFG---QVAAAGVSSNPFMTGA-----PTGQLPT-----GS 570

  Fly   989 ALTRP 993
            :.|.|
Mouse   571 SSTNP 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	32/118 (27%)
		Ank_2	554..662	CDD:403870	20/110 (18%)
		ANK repeat	586..622	CDD:293786	9/38 (24%)
		ANK repeat	624..662	CDD:293786	2/37 (5%)
		Ank_2	636..>693	CDD:403870	6/56 (11%)
		SH3_ASAP	1095..1149	CDD:212755
Agfg1	XP_006496493.1	COG5347	8..268	CDD:227651	70/329 (21%)
Agfg1	XP_006496493.1	ArfGap_AGFG1	13..128	CDD:350082	32/118 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900