DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and Acap3

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_997106.1	Gene:	Acap3 / 140500	MGIID:	2153589	Length:	833	Species:	Mus musculus

Alignment Length:	883	Identity:	183/883 - (20%)
Similarity:	319/883 - (36%)	Gaps:	258/883 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTHVDNEMFMVRALERLGGKVIEQDEPDIG 96
            |..|.||..:|..:......|.||.|....:..:|..:|......|..:..|..:.  |.:..|.
Mouse    13 PRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQQC--QGDTVIS 75

  Fly    97 AAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFDKAAKDYEAKFIKI 161
            ....:|....:|:......|.......|...:.:.:|.::|..| :.|:.|||..:|.|...:
Mouse    76 ECLQRFGDSLQEMVNYHTILFDQAQRSVRQQLHNFVKEDVRKFK-ETKKQFDKVREDMELSLV-- 137

  Fly   162 EKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIKTKTGIELLQHLIEYYH 226
               :.|||....  ..|::.|..|  :...|:.::....:|:|:...::.|...|:|..::.:.|
Mouse   138 ---RNAQAPRHR--PHEVEEATGA--LTVTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMH 195

  Fly   227 ALSNYFKDGLQTIEHFGTYIGDLSEKLHE------IKQKQDEDRRSLLDLRTVLRSTPDFERVDN 285
            |..::|:.|...:.....|:..|:.:|.:      :::::.|.:.:.:..||:|:   ||..  :
Mouse   196 AQYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQ---DFSY--D 255

  Fly   286 VPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGFLDIFHADES 350
            .|..|            ...|...||..:|:|.|::.... :.|.:|...:.:.   .:.:..:.
Mouse   256 EPKVE------------FDVDAPSGVVMEGYLFKRASNAF-KTWNRRWFSIQNS---QLVYQKKL 304

  Fly   351 KPPTRV---NLLTCQIKPVPDDKRG--FDLISYNRPYHFQAEDEGDQKAWMAVLVNCKEKALTKA 410
            |....|   :|..|.:||..|.:|.  |:::|..:....||:.|..::||    |...:.::..|
Mouse   305 KDALTVVVDDLRLCSVKPCEDIERRFCFEVVSPTKSCMLQADSEKLRQAW----VQAVQASIASA 365

  Fly   411 FQHA---------NPQMSPSLVELQKT------------VIRYVQLLPGNDRCCDCGSRNDVTWI 454
            ::.:         :...|||...:..|            |::.||.:.||.:|.||| :.|..|.
Mouse   366 YRESPDSCYSERLDRTASPSTSSIDSTTDSRERGVKGESVLQRVQSVAGNSQCGDCG-QPDPRWA 429

  Fly   455 SLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKL---GRGK 516
            |:|.|:|:||:|||:||.||||.|:::|||||:.....|.:...:||||:|.|.||:.   |..|
Mouse   430 SINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQCEGPGVRK 494

  Fly   517 LQHESSMEERYDFIRAKYVAKRYVMRT-------------------------------------- 543
            ....||.:::..:|:.|||.|:::.:.
Mouse   495 PTASSSRQDKEAWIKDKYVEKKFLRKLTSAPAREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPV 559

  Fly   544 -----------------------CSDDND-----------------LRCD--------------- 553
                                   |.|:.|                 |..|
Mouse   560 LPSVAALSSAATMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLA 624

  Fly   554 ---------------------------------------------LEQAVVNADMSQLLQVWAEG 573
                                                         ..||....|:..|....|.|
Mouse   625 FGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRELHPGLLAHQAARTRDLPALAAALAHG 689

  Fly   574 ADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHL 638
            |::... .::|.|:|.|..|||   |.:|.:.:||:||  ...:|:.       |..|: ..||.
Mouse   690 AEVNWA-DAADEGKTPLVQAVL---GGSLIVCEFLLQN--GADVNQR-------DSLGR-APLHH 740

  Fly   639 CALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWN 703
            ..|..|...:.|.|:.|||....:.:.:..|.||.:..:.....|:..|
Mouse   741 ATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLA---------------- 789

  Fly   704 LPNEDGSTDFSDDETVIDERKSRSRPPSFAG---GDSP 738
                          .:.:|.:....||...|   |.||
Mouse   790 --------------RMAEEMREAEAPPGQPGPLPGSSP 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	44/213 (21%)
		PH_ASAP	302..410	CDD:270071	24/112 (21%)
		ArfGap_ASAP	425..541	CDD:350063	51/130 (39%)
		Ank_2	554..662	CDD:403870	32/107 (30%)
		ANK repeat	586..622	CDD:293786	13/35 (37%)
		ANK repeat	624..662	CDD:293786	11/37 (30%)
		Ank_2	636..>693	CDD:403870	14/56 (25%)
		SH3_ASAP	1095..1149	CDD:212755
Acap3	NP_997106.1	BAR_ACAP3	16..215	CDD:153321	43/210 (20%)
		PH	269..363	CDD:278594	22/101 (22%)
		PH_ACAP	271..367	CDD:270070	22/103 (21%)
		ArfGap	403..521	CDD:279720	50/118 (42%)
		ANK	671..786	CDD:238125	35/128 (27%)
		Ank_2	671..764	CDD:289560	32/106 (30%)
		ANK repeat	700..731	CDD:293786	13/42 (31%)
		ANK repeat	733..764	CDD:293786	10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820