Protein Alignment Asap and Asap1

DIOPT Version :10

• Sequence 1: NP_001014504.1
• Gene: Asap / 35783
• FlyBaseID: FBgn0050372
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_006520455.1
• Gene: Asap1 / 13196
• MGIID: 1342335
• Length: 1223
• Species: Mus musculus
• Alignment Length: 1238
• Identity: 474/1238 - (38%)
• Similarity: 666/1238 - (53%)
• Gaps: 219/1238 - (17%)

  Fly     1 MPPSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNS 65
            |.|:::.:.|           |.||:|               |.|:.||..|.|:||:||||:||
Mouse   122 MTPAVLHLGE-----------PYTSSF---------------EALDQDRTALQKVKKSVKAIYNS 160

  Fly    66 GNTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDS 130
            |..||.||....:.|::.|...:.:|.||:|.||:|||.:|||||.|:|.|:|.:::.|:|.:||
Mouse   161 GQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDS 225

  Fly   131 MLKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLY 195
            :||.:|:|||||:|:|||||.||||.||.||||||:..||:.||:||||..|.:||||||||||:
Mouse   226 LLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLF 290

  Fly   196 QLQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQ 260
            |||.||||:|..:||||.|::|||:||:||||..|:|:|||:|.:....||..|:..|:.|||.|
Mouse   291 QLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQ 355

  Fly   261 DEDRRSLLDLRTVLRSTPDFERVD----------NVPSSESRSGGAGYSLHQLQGDKHHGVTRQG 315
            ||:::.|..||.:::|:...:..:          |....:|:|...|||:|||||:|.:|..::|
Mouse   356 DEEKKQLTALRDLIKSSLQLDPKEVGGLYVASRANSSRRDSQSRQGGYSMHQLQGNKEYGSEKKG 420

  Fly   316 HLLKKSEGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNR 380
            .|||||:| :|:|||:|:|.| .:|.|.|.||..::.|.::||||||:||..:||:.|||||:||
Mouse   421 FLLKKSDG-IRKVWQRRKCAV-KNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNR 483

  Fly   381 PYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDC 445
            .||||||||.|..||::||.|.||:|||.||:........||.:|.|.:|..||.|||||.||||
Mouse   484 TYHFQAEDEQDYIAWISVLTNSKEEALTMAFRGEQSTGENSLEDLTKAIIEDVQRLPGNDICCDC 548

  Fly   446 GSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEA 510
            || ::.||:|.|.|||.||:|||:||::|||.||||||.||.|.|:.||:|:.:||::.||||||
Mouse   549 GS-SEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEA 612

  Fly   511 KL--GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEG 573
            .|  ...|....|.|..|.::|.||||..|:..:||:..:....:|.:|:.:.|:..|:||:|||
Mouse   613 NLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCASSSAKLNELLEAIKSRDLLALIQVYAEG 677

  Fly   574 ADLTCCL--PSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTAL 636
            .:|...|  |..:.|||||||||.....::||:||||:||.  ..|:|.|:..        ||.|
Mouse   678 VELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNC--GNLDKQTSVG--------NTVL 732

  Fly   637 HLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTD 701
            |.|:::.:.||:||||||....::.|...:|||||||.:....|.:|:..|...:.:...|:..:
Mouse   733 HYCSMYGKPECLKLLLRSKPTVDIVNQNGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYE 797

  Fly   702 WNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRS----STCDSIQSSSSPIANCPS 762
            |||..::  .|.|||:  :|::            .||:.:.||    |.|.|  ||.||......
Mouse   798 WNLRQDE--MDESDDD--LDDK------------PSPIKKERSPRPQSFCHS--SSISPQDKLAL 844

  Fly   763 RQFTLPSGLPSYTHSAGTSPKQHISVGQ-----YLGSATNVGGN--------GPGNGGSSPSSAS 814
            ..|:.|            ..||.:|.|.     :..::|::..:        .|.|.|..|:...
Mouse   845 PGFSTP------------RDKQRLSYGAFTNQIFASTSTDLPTSPTSEAPPLPPRNAGKGPTGPP 897

  Fly   815 SQSVRAARNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPG---TLGSASSSSFYGTLP 876
            |..      .|..|:..|.              ::|.|:..|.||||   ||....|     .||
Mouse   898 STL------PLGTQTSSGS--------------STLSKKRPPPPPPGHKRTLSDPPS-----PLP 937

  Fly   877 HPPRH-------------SQNFDASDIRAINHK--NQSLDVAYG-----TLPH---LRSVESSPR 918
            |.|.:             |.:..|:....::.:  ..|...|.|     .||.   ||..|:|
Mouse   938 HGPPNKGAIPWGNDVGPLSSSKTANKFEGLSQQASTSSAKTALGPRVLPKLPQKVALRKTETS-- 1000

  Fly   919 GGGGYGYGVSQD-----PGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLV--LPP- 975
                  :.:|.|     |......|..:.:|       ::.|.||...:.:.||....|  |||
Mouse  1001 ------HHLSLDRTNIPPETFQKSSQLTELP-------QKPPLGELPPKPVELAPKPQVGELPPK 1052

  Fly   976 TGELPTLKHVDKSALTRPK-----IPP-------PGPPSEREI-SNGQSNESISSMDEGPVA--- 1024
            .||||            ||     :||       |..|..::: ...|..:.::....|.|:
Mouse  1053 PGELP------------PKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQAGDVSAKV 1105

  Fly  1025 -PPRKLVNQSANFPDYESWHT-DMDSSGGGLDHSAESNVSSSDNDRLNSSPDNPSKTGGAGLGGK 1087
             ||.::..:|         || |:..:....| :.:...|...||...:.|:.|.........||
Mouse  1106 QPPSEVTQRS---------HTGDLSPNVQSRD-AIQKQASEDSNDLTPTLPETPVPLPRKINTGK 1160

  Fly  1088 FHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGIIEGQPTRKGMFPVSFVHM 1152
               |..||.:.:|||.|||||||.|.|||::||..|  :|:.|..|.|||||.|||:|||||||:
Mouse  1161 ---NKVRRVKTIYDCQADNDDELTFIEGEVIIVTGE--EDQEWWIGHIEGQPERKGVFPVSFVHI 1220

  Fly  1153 LPD 1155
            |.|
Mouse  1221 LSD 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	118/213 (55%)
		PH_ASAP	302..410	CDD:270071	62/107 (58%)
		ArfGap_ASAP	425..541	CDD:350063	65/117 (56%)
		ANKYR	<573..709	CDD:440430	52/137 (38%)
		ANK repeat	586..622	CDD:293786	19/35 (54%)
		ANK repeat	624..662	CDD:293786	13/37 (35%)
		Vac17	<706..>788	CDD:435863	20/85 (24%)
		SH3_ASAP	1095..1149	CDD:212755	32/53 (60%)
Asap1	XP_006520455.1	BAR_ASAP1	138..344	CDD:153325	118/205 (58%)
		PH_ASAP	407..513	CDD:270071	62/107 (58%)
		ArfGap_ASAP1	528..649	CDD:350073	66/121 (55%)
		ANKYR	<673..784	CDD:440430	50/120 (42%)
		ANK repeat	692..725	CDD:293786	19/34 (56%)
		ANK repeat	727..758	CDD:293786	13/38 (34%)
		PHA03247	<816..1154	CDD:223021	90/413 (22%)
		SH3_ASAP1	1165..1221	CDD:212898	36/57 (63%)