DRSC/TRiP Functional Genomics Resources

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Protein Alignment Asap and AGAP3

DIOPT Version :9

Sequence 1:NP_001014504.1 Gene:Asap / 35783 FlyBaseID:FBgn0050372 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_114152.3 Gene:AGAP3 / 116988 HGNCID:16923 Length:911 Species:Homo sapiens


Alignment Length:592 Identity:134/592 - (22%)
Similarity:226/592 - (38%) Gaps:149/592 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIKTKTGIELLQHLIEYY 225
            |.|:.|.        |:.|..:....::::|::..:.:. :.:...:.|..|.||.|.:.    .
Human   364 IRKQSKR--------RSNIFTSRKGADLDREKKAAECKV-DSIGSGRAIPIKQGILLKRS----G 415

  Fly   226 HALSNYFKDGLQTIEHFG--TYIGDLSEKLHEIKQKQDEDRRSLLDL--RTVLRSTPDFERVDNV 286
            .:|:..:|....|:...|  ||...|.:.:..|..|:.:..|:.:.:  :.:.|:||     ...
Human   416 KSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATP-----ATA 475

  Fly   287 PSSESRSGGAGYSLHQLQ-----GDKHHGVTRQGHLLKKSEGKV-RRVW--------QKRRCRVT 337
            |.:..|:.|........|     |..|...:...|    ||..: ...|        .:|.|.|:
Human   476 PGTSPRANGLSVERSNTQLGGGTGAPHSASSASLH----SERPLSSSAWAGPRPEGLHQRSCSVS 536

  Fly   338 S-DGFLDIFHADESKPPTR-------VNLLTCQIK----------------------PVPDD--- 369
            | |.:.:   |..|.||..       ..:|:...|                      |.||.   
Human   537 SADQWSE---ATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSS 598

  Fly   370 -----KRGFDLISYN---RPYHFQAEDEGDQKAW--------MAVLVNCKEKALTKAFQHANPQM 418
                 :..|:.:..:   :.:||:|....:::.|        :|.|..|:.........:.|..:
Human   599 ATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAAL 663

  Fly   419 SPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSL 483
            :          ::.|:.:.||..|.||.:.|. .|.|||.|.|:||:|||:||.||.|.||::||
Human   664 A----------VQAVRTVRGNSFCIDCDAPNP-DWASLNLGALMCIECSGIHRHLGAHLSRVRSL 717

  Fly   484 TLDNLTTANLLIARAMGNSTLNDIMEAKL-GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDD 547
            .||:.....|.:..||||:..|.:.|..| |..|...::..||:..:|||||..|.::....|.|
Human   718 DLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSD 782

  Fly   548 NDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNM 612
            ..|...|.:|||..|:..|:.:.|.|:       ..:..||         .|             
Human   783 VPLGQQLLRAVVEDDLRLLVMLLAHGS-------KEEVNET---------YG------------- 818

  Fly   613 PPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGH 677
                           |..|: |||||.:........:||:..|.|...::::..|.|..|:..|.
Human   819 ---------------DGDGR-TALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGS 867

  Fly   678 NSCRELI 684
            ..|.:::
Human   868 QECADIL 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsapNP_001014504.1 BAR_ASAPs 35..249 CDD:153288 17/89 (19%)
PH_ASAP 302..410 CDD:270071 29/170 (17%)
ArfGap_ASAP 425..541 CDD:350063 47/116 (41%)
Ank_2 554..662 CDD:403870 22/107 (21%)
ANK repeat 586..622 CDD:293786 3/35 (9%)
ANK repeat 624..662 CDD:293786 11/37 (30%)
Ank_2 636..>693 CDD:403870 12/49 (24%)
SH3_ASAP 1095..1149 CDD:212755
AGAP3NP_114152.3 small_GTPase 126..291 CDD:197466
Centaurin_gamma 128..285 CDD:133303
PH_AGAP 401..645 CDD:241281 48/259 (19%)
PH 404..>465 CDD:278594 14/64 (22%)
ArfGap 664..778 CDD:279720 47/124 (38%)
Ank_2 789..879 CDD:289560 27/131 (21%)
ANK 789..>878 CDD:238125 27/131 (21%)
ANK repeat 789..819 CDD:293786 11/73 (15%)
ANK repeat 821..852 CDD:293786 10/31 (32%)
ANK repeat 854..879 CDD:293786 5/21 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D751525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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