DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and AGAP1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006712302.2	Gene:	AGAP1 / 116987	HGNCID:	16922	Length:	1151	Species:	Homo sapiens

Alignment Length:	403	Identity:	106/403 - (26%)
Similarity:	173/403 - (42%)	Gaps:	75/403 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 DNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKS-------------EGKVRRVWQKRRCR 335
            |:|.||.|.|....   .:|.........|:.|..|||             |.| |:.|:..|.
Human   769 DSVCSSPSISSTTS---PKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEAK-RKAWKLNRV- 828

  Fly   336 VTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYN---RPYHFQAEDEGDQKAWMA 397
                |.|...::..:.              ..:.:..|:.|..:   :.:||:|....::.||:.
Human   829 ----GSLRNIYSSSTN--------------TEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQ 875

  Fly   398 VLVNCKEKALTKAFQHANPQMSPSLVELQK--TVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGI 460
            .:    |..:..:.|......:.|.:..|.  ..::.::.:.||..|.||.::|. .|.|||.|.
Human   876 AI----ESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNP-NWASLNLGA 935

  Fly   461 LVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIM-EAKLGRGKLQHESSME 524
            |:||:|||:||:||.|.||::||.||:.....:.:..::||...|.:. |:..||.|...:|:.|
Human   936 LMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTRE 1000

  Fly   525 ERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGA----DLTCCLPSSDA 585
            |:..:|||||..|.::......:..|...|.:|..:.|:...:.:.|.|:    :.||   ....
Human  1001 EKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETC---GEGD 1062

  Fly   586 GETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGK----NTALHLCALHDRRE 646
            |.||||||..:  |:.:     |.|.:...|          :|||.:    ||||........:|
Human  1063 GRTALHLACRK--GNVV-----LAQLLIWYG----------VDVTARDAHGNTALAYARQASSQE 1110

  Fly   647 CMKLLLRSGADYE 659
            |:.:||:.|...|
Human  1111 CIDVLLQYGCPDE 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	21/123 (17%)
		ArfGap_ASAP	425..541	CDD:350063	45/118 (38%)
		Ank_2	554..662	CDD:403870	31/114 (27%)
		ANK repeat	586..622	CDD:293786	11/35 (31%)
		ANK repeat	624..662	CDD:293786	13/40 (33%)
		Ank_2	636..>693	CDD:403870	7/24 (29%)
		SH3_ASAP	1095..1149	CDD:212755
AGAP1	XP_006712302.2	Centaurin_gamma	337..498	CDD:133303
		RAS	338..504	CDD:214541
		PH_AGAP	613..886	CDD:241281	27/143 (19%)
		PH	616..>680	CDD:278594
		PH	<830..881	CDD:278594	9/68 (13%)
		ArfGap	905..1019	CDD:279720	44/114 (39%)
		Ank_2	1030..1120	CDD:289560	29/109 (27%)
		ANK	1030..>1119	CDD:238125	29/108 (27%)
		ANK repeat	1062..1093	CDD:293786	14/47 (30%)
		ANK repeat	1095..1120	CDD:293786	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820