DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and acap2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_004914426.1	Gene:	acap2 / 100497437	XenbaseID:	XB-GENE-990716	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	860	Identity:	196/860 - (22%)
Similarity:	331/860 - (38%)	Gaps:	220/860 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTH-VDNEMFM 76
            ||...|  ||   .|.:.:.|....:..||.:|:       ||.|....:.::|... ..|:.||
Frog     8 EECLKD--SP---RFRASLEDVEGDVAELEMKLD-------KLVKLCIGMIDAGKAFCAANKQFM 60

  Fly    77 --VRALERLGGK--VIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELR 137
              :|.|.:...|  |||       ::..||:...:|:......|.......:...:.:.:|.:|:
Frog    61 NGIRDLAQYSSKDSVIE-------SSLTKFADSLQEMIKYHAMLFDQAQRSIKTQLQTFVKEDLK 118

  Fly   138 GVKGDMKRPFDKAAKDYEAKFIK---IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQT 199
            ..| |.|:.|||.:::.|...:|   .::.|:.:.:||    |.|..|.        |:.::...
Frog   119 KFK-DAKKQFDKVSEEKENALVKNAQAQRTKQHEVEEA----TNILVAT--------RKCFRHIA 170

  Fly   200 CEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEI-----KQK 259
            .:|:|:...:::|...|:|:.::.:.:|...:|..|.........::.||..:|..:     |:|
Frog   171 LDYVLQINVLQSKRRSEILKSMLSFMYAHLTFFHQGYDLFSELEPHMKDLGAQLDNLVGDAAKEK 235

  Fly   260 QD-EDRRSLLDLRTVLRSTPDFERVD-----NVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLL 318
            :| |.:.|.:..:       ||...|     ||                   |...|:..:|:|.
Frog   236 RDMEIKHSTIQQK-------DFADDDTKLECNV-------------------DTTSGIVMEGYLF 274

  Fly   319 KKSEGKVRRVWQKRRCRVTSDGFLD-----IFHADESKPPTRV--NLLTCQIKPVPDDKRG--FD 374
            |::.... :.|.:::...|...|..     ::.......||.|  :|..|.:||..|.:|.  |:
Frog   275 KRASNAF-KTWNRKKPDHTRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKPCEDIERRFCFE 338

  Fly   375 LISYNRPYHFQAEDEGDQKAWM-----AVLVNCKEKALTKAFQHANPQMSPSLVELQ-------- 426
            ::|..:....||:.:..::||:     ::....:||..........|.:|.:..|.:
Frog   339 VVSPTKSCILQADSDKLRQAWIKAVQTSIATAYREKGDEAEKAEKKPSVSITSPESETKENLVKG 403

  Fly   427 KTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTA 491
            ::.::.||.:|||..||||| .:|..|.|:|.||.:||:|||:||.||||.|:::|||||.....
Frog   404 ESALQRVQCIPGNTNCCDCG-LSDPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPE 467

  Fly   492 NLLIARAMGNSTLNDIMEA---KLGRGKLQHESSMEERYDFIRAKYVAKRYV------------- 540
            .|.:...:||..:|.|.||   |:|..|.||....:|:..:|:||||.|::|
Frog   468 LLKLMCELGNDVMNSIYEARVEKMGVRKPQHGCQRQEKEAYIKAKYVEKKFVDKYSDSSLMVYKR 532

  Fly   541 ---------------MRTCS---------------------------------DDNDLRCD---- 553
                           .||.|                                 .|.:.:.|
Frog   533 SPSLSKADRLSSEPLTRTPSKSSVKSNDSGIQFSAEVSREGLAVTASSNSLFDQDGEKKDDKQDS 597

  Fly   554 ----------------LEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTL 602
                            |.||....::..:.:..|.||::...   :..|..|..| :....|.:|
Frog   598 SAFQELNVKKLLPGPQLFQASYEGNLPGMAEALAHGAEVNWV---NTKGNNATPL-IQAVHGGSL 658

  Fly   603 HIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCAL-HDRRECMKLLLRSGADYELKNSQNK 666
            ...:||:||    |.|....     |:.|:....|...| |..:.|  |.|:.||:....:...|
Frog   659 VTCEFLLQN----GANVNNR-----DIKGRGPLHHATLLGHTGQVC--LFLKRGANQHASDEDGK 712

  Fly   667 TALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPS 731
            ..|.||.:..:.....|:..|...|:           :...:|......|||..|..:..|...|
Frog   713 DPLTIAIDAANADIVTLLRLARMNEE-----------MRESEGLYGQPGDETYQDIFRDFSHMAS 766

  Fly   732 --------FAGGDSP 738
                    |...|||
Frog   767 NNPEKLNRFHQSDSP 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	45/221 (20%)
		PH_ASAP	302..410	CDD:270071	25/121 (21%)
		ArfGap_ASAP	425..541	CDD:350063	53/154 (34%)
		Ank_2	554..662	CDD:403870	27/108 (25%)
		ANK repeat	586..622	CDD:293786	11/35 (31%)
		ANK repeat	624..662	CDD:293786	10/38 (26%)
		Ank_2	636..>693	CDD:403870	15/57 (26%)
		SH3_ASAP	1095..1149	CDD:212755
acap2	XP_004914426.1	BAR_ACAP2	18..217	CDD:153322	46/225 (20%)
		PH_ACAP	269..372	CDD:270070	21/103 (20%)
		ArfGap_ACAP2	404..519	CDD:350076	52/115 (45%)
		Ank_2	614..708	CDD:372319	27/108 (25%)
		ANK repeat	614..640	CDD:293786	6/28 (21%)
		ANK repeat	642..675	CDD:293786	11/42 (26%)
		ANK repeat	677..708	CDD:293786	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010