DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and agap2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_002933734.3	Gene:	agap2 / 100496997	XenbaseID:	XB-GENE-1011294	Length:	2037	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	178/906 - (19%)
Similarity:	297/906 - (32%)	Gaps:	339/906 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHN--SGN---------------THVDNE 73
            |.:..:|:.|  :|||         |.||..|:. .:|.  :|:               ..|:.:
Frog  1289 TLSRTVPEIR--VGVL---------GSTKSAKSA-LVHRFVTGSYQPLEAPESAQFKKEISVEGQ 1341

  Fly    74 MFMVRALERLGGKVIEQDEPD------IGAAFLKFSVVTKELSALMKTLMQ------NINNIVMF 126
            .:::...|..|.       ||      :.|....||:   |..|..:.:.|      |..|:
Frog  1342 SYLLLIREEAGA-------PDAKFANWVDAVIFVFSL---ENEASFQDIFQYYALLANYRNV--- 1393

  Fly   127 PVDSMLKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAV--VAEEME 189
               :.|...|.|.:..:.....:..:|..|:.:..:.::....:........:|...  ||::|.
Frog  1394 ---ADLAMALVGTQDKISANNKRVVEDVRARALCNDIKRCVYYETCATYGLNVDRVFNEVAQKMV 1455

  Fly   190 KERRLYQLQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLH 254
            ..:|..||.:|:.|.......:.:            .|:|....:|       || ..|.|..|.
Frog  1456 AIKRQQQLLSCKSLPSSPSHSSGS------------IAISVQASNG-------GT-TSDYSSSLP 1500

  Fly   255 EIKQKQDEDRRSLLDL--------------RTVL---RSTPDFERVDNVPSSESRSGGAGYSLHQ 302
            ........:.||.:.:              ||.:   |...|.|:    .|.:||:.|||
Frog  1501 STPNISHRELRSEVSIGVSTPVSLHRGTKRRTSIFTNRRGSDLEK----RSFDSRADGAG----- 1556

  Fly   303 LQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGFL-------DIFHADESK--------- 351
              |.:...: :|..|:|:|...:.:.|:|:...:||:|.|       |..|:...|
Frog  1557 --GGRALPI-KQSFLMKRSGNSLNKEWKKKYVTLTSNGVLLYHPSINDYLHSTHGKEMDLLRTTV 1618

  Fly   352 ---------------PPTRVNLLTCQI------------------------------------KP 365
                           |...:|.|...:                                    .|
Frog  1619 KVPGKRPPIAMSACGPSNSINGLLKDVGSSPGGDTASNKAQSTKSKSTGDVISSPTSNKDPPSSP 1683

  Fly   366 VPDDKR------------------------------------------GFDLI---SYNRPYHFQ 385
            :.|.|:                                          .|:.|   |..:.:||:
Frog  1684 MSDKKKNRRKKNMTPSKTEGSAGQADAKRKMWKLKTFGSLRNIYKTEENFEFIIVSSTGQTWHFE 1748

  Fly   386 AEDEGDQKAWMAVL-------VNCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCC 443
            .....::.:|:..:       :.|.|.:..||...:         :.:...|:.::...||..|.
Frog  1749 TSSFEERDSWVQAIESQILASLQCCESSKNKARMDS---------QSEAVAIQAIRNAKGNSFCV 1804

  Fly   444 DCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIM 508
            |||:.|. ||.|||.|.|:||:|||:||:||.|.||::||.||:......|:..::||...|.|.
Frog  1805 DCGAPNP-TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPLELTLVLTSIGNEMANSIW 1868

  Fly   509 EAKL-GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAE 572
            |... ||.|...:||.|||..:|||||
Frog  1869 EMTTHGRTKPAPDSSREERESWIRAKY-------------------------------------- 1895

  Fly   573 GADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKA------TNPAGLLDVTG 631
                          |..|.||.|:..|  :.:|..|.:.:..|.|...      :|...:..:||
Frog  1896 --------------EQRLFLAPLKSPG--VPLVKQLFKAVHEKNLGNVLLLLAHSNKEQINGITG 1944

  Fly   632 ---KNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKS 693
               :.||||:..........:||:..|.|.:.::|...||:..||:.....|.:::
Frog  1945 DRDRRTALHVACELGEVVTTQLLVWYGIDVKSRDSNGHTAVFYAKKSNSQECVDIL--------- 2000

  Fly   694 AFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSS 754
             ..|     ..|||                       |.:...:|.||.:||:...:::.|
Frog  2001 -LQH-----GCPNE-----------------------STSALSTPSLRRKSSSASIVRTDS 2032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	42/244 (17%)
		PH_ASAP	302..410	CDD:270071	28/226 (12%)
		ArfGap_ASAP	425..541	CDD:350063	50/116 (43%)
		Ank_2	554..662	CDD:403870	21/116 (18%)
		ANK repeat	586..622	CDD:293786	10/41 (24%)
		ANK repeat	624..662	CDD:293786	10/40 (25%)
		Ank_2	636..>693	CDD:403870	12/56 (21%)
		SH3_ASAP	1095..1149	CDD:212755
agap2	XP_002933734.3	PHA03247	<111..662	CDD:223021
		PHA03247	<470..878	CDD:223021
		Centaurin_gamma	1297..1454	CDD:133303	31/184 (17%)
		PH_AGAP	1559..1771	CDD:241281	25/212 (12%)
		ArfGap_AGAP	1789..1896	CDD:350065	50/159 (31%)
		Ank_2	1915..2005	CDD:403870	21/104 (20%)
		ANK repeat	1915..1945	CDD:293786	5/29 (17%)
		ANK repeat	1947..1978	CDD:293786	8/30 (27%)
		ANK repeat	1980..2005	CDD:293786	6/39 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920