DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and acap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_031755514.1	Gene:	acap1 / 100496659	XenbaseID:	XB-GENE-6257486	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	858	Identity:	189/858 - (22%)
Similarity:	326/858 - (37%)	Gaps:	215/858 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTHVDNEMFMV 77
            ||:.:|  ||.|   .:.|.:....:..||.|||       ||.|....:::.|..:..:....|
Frog     8 EESLTD--SPRT---RAAMEEVECEVSDLESRLE-------KLVKLSSHMNDGGRQYCSSSRHFV 60

  Fly    78 RALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELRGVKGD 142
            .||..|...  .|.:..:.....:||....::......|::||.......:..:||.:||..: |
Frog    61 EALRDLSHH--SQKDSMLSECLERFSDGLSKIIDSHVELLENIQFSFKQRLLHLLKEDLRSFR-D 122

  Fly   143 MKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYK 207
            .::..::..:..|:......:..:.:|:||.      ||   |..::..|:.::.:..||.|:..
Frog   123 SRKDMERCREGLESALHHNAETARRKAQEAQ------DA---ASAVQGSRKAFRDRALEYALQIN 178

  Fly   208 DIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDEDRRSLLDLRT 272
            .|:.|...::||.:::...|.::........::....|..:|:.::|....:...::|.:....|
Frog   179 VIQGKKKFDILQFMLQLMDAQASSLAQSHHAMQALDQYRNELAAQVHRSVLEAAREQRDMEQKVT 243

  Fly   273 VLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVT 337
            ::::..        ||.|.         ..||||... |..:|:|.|::.... :.|.:|...:.
Frog   244 LIKAKD--------PSDED---------SVLQGDGAQ-VVIEGYLFKRASNTF-KTWSRRWFSIQ 289

  Fly   338 SDGF-----LDIFHADESKPPTRVNLLTCQIKPVPDDKRG--FDLISYNRPYHFQAEDEGDQKAW 395
            ::..     :|:...      ..|:|..|.:|..|:.:|.  |:::|..:....|||.:...:.|
Frog   290 NNQLVYQKKVDVLTV------VIVDLRLCAVKLCPEAERRFCFEVVSPAKSCMLQAESDRVLQLW 348

  Fly   396 MAVLVNCKEKALTKAFQH-----------ANPQMSPS----LVELQKTVIRYVQLLPGNDRCCDC 445
                |:..::::|.|:..           .:|..:|:    :...|..|:|    :|||..||||
Frog   349 ----VSAVQRSITTAYSDNKRESGSLRLPRSPAEAPAQEKGVQGAQDAVLR----VPGNASCCDC 405

  Fly   446 GSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEA 510
            .:. :..|.|:|.|:.:||:|||:||.||||.|:::|||||:.....:.:...:||||:|.|.||
Frog   406 RTA-EPEWASINLGVTLCIECSGIHRSLGVHFSKVRSLTLDSWEPELIKLMCELGNSTINGIYEA 469

  Fly   511 KLGRGKLQH---ESSMEERYDFIRAKYVAKRYV-------------------------------- 540
            ::....::.   .||..|:..:||||||.|:::
Frog   470 RIEDMNIRKPTAASSRSEKEVWIRAKYVEKKFITKLPQSSLRSPRHSQPDPPSHSPKARTLGQRP 534

  Fly   541 ------------------MRTCSDDNDLRCDLEQAVVNADMSQ-----------------LLQVW 570
                              .|..|.....|.:.|:..:..:..:                 |....
Frog   535 NSGPDLKALSRPFAQTELQRPISSPGAQRQNTEETEIEPENGRQVRLRKATRPLLRPKPGLATAR 599

  Fly   571 AEGAD-----------------LTCCLP----------------SSDAGETALHLAVLREMGSTL 602
            |||||                 ...|||                |.:.|.|.|..|||   .::|
Frog   600 AEGADGKDVRSLHPGALLYRAVEHRCLPTMADALAHGADVNWVRSEERGYTPLIRAVL---SNSL 661

  Fly   603 HIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKT 667
            ...:||:||      ..:.|..   |..|:. .||...|........|.|:.|||....::..|.
Frog   662 VASEFLLQN------GASVNQT---DKDGRG-PLHHATLQGYTGLACLFLKRGADINAVDNSGKD 716

  Fly   668 ALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSF 732
            .|.||.|..:.....|:.....||               .|.:...|.|||.:|    ..|..|.
Frog   717 VLSIAIENANADIVTLLRLVKMRE---------------ADIALGQSGDETYLD----IFRDFSL 762

  Fly   733 AGGDSPVLRSRSS 745
            ...|:|...||.|
Frog   763 MASDAPEKLSRRS 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	41/213 (19%)
		PH_ASAP	302..410	CDD:270071	25/114 (22%)
		ArfGap_ASAP	425..541	CDD:350063	49/168 (29%)
		Ank_2	554..662	CDD:403870	33/157 (21%)
		ANK repeat	586..622	CDD:293786	11/35 (31%)
		ANK repeat	624..662	CDD:293786	10/37 (27%)
		Ank_2	636..>693	CDD:403870	16/56 (29%)
		SH3_ASAP	1095..1149	CDD:212755
acap1	XP_031755514.1	BAR_ACAP1	18..217	CDD:153323	41/217 (19%)
		PH_ACAP	266..361	CDD:270070	21/105 (20%)
		ArfGap	387..506	CDD:355783	49/123 (40%)
		ANKYR	<633..734	CDD:223738	29/113 (26%)
		ANK repeat	647..678	CDD:293786	12/42 (29%)
		ANK repeat	680..711	CDD:293786	9/31 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010