DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and asap2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_002935078.3	Gene:	asap2 / 100494274	XenbaseID:	XB-GENE-1002636	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	1206	Identity:	476/1206 - (39%)
Similarity:	652/1206 - (54%)	Gaps:	235/1206 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |.||:|||||.||..||.|||.|.|.:|:..||:|:..::|.||.|...|.|:||:|||||.||.
Frog     2 PDLISVSEFVCETNEDYKSPTASNFTNRLSQCRNTVVAIDEALEVDHTILNKMKKSVKAIHTSGL 66

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            |||:||....:|||:.|...:.:|:||:|.|||||||.||||:||.|.|:||:|||:.||:||:|
Frog    67 THVENEEQYTQALEKFGSNCVCRDDPDLGTAFLKFSVFTKELTALFKNLVQNMNNIITFPLDSLL 131

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |.:|:||||::|:||:||.||||.|..|||||||..||..||:||||..|.:|||||||||::||
Frog   132 KGDLKGVKGELKKPFEKAWKDYETKVTKIEKEKKEHAKMHGMIRTEISGAEIAEEMEKERRVFQL 196

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||||..:||.|.|::|||:||:|:||..|:|:|||:.:|.....|..||..||.|||.|||
Frog   197 QMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVETLKPSIEKLSTDLHTIKQVQDE 261

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRR 327
            :|:.|..||.:|::....|:.::   |:.|...| |||||.||:|.||..|.|:|.|||:| :|:
Frog   262 ERKQLSQLRDILKAALQVEQKED---SQIRQSVA-YSLHQPQGNKEHGSERDGYLYKKSDG-IRK 321

  Fly   328 VWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGDQ 392
            |||||:|.| .:|||.|.|...:.||.::||||||:|..|::|:.|||||::|.||||||||.:.
Frog   322 VWQKRKCTV-QNGFLTISHGTANIPPAKLNLLTCQVKTNPEEKKSFDLISHDRTYHFQAEDETEC 385

  Fly   393 KAWMAVLVNCKEKALTKAFQHANPQMSPSLV-ELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISL 456
            :.||:||.|.||:||..||:..:.....::| ||.|.:|..:|.:||||.|||||: :|.||:|.
Frog   386 QIWMSVLQNSKEEALNNAFKGDHSAGENNIVQELTKEIISDIQRMPGNDVCCDCGA-SDPTWLST 449

  Fly   457 NFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRG---KLQ 518
            |.|||.||:|||:||:||||:|||||||||.|.|:.||:|:.:|||..|::|||.|...   |..
Frog   450 NLGILTCIECSGIHRELGVHYSRIQSLTLDVLGTSELLLAKNIGNSGFNELMEACLPADDSVKPS 514

  Fly   519 HESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLP-- 581
            ..|.|..|.|:|..||:.::|..|...|:......|..||.:.|:..|:|:.|||.|||..:|
Frog   515 PCSDMNARKDYITTKYIERKYARRKYHDNASKLHGLCDAVKSRDIFTLVQLHAEGVDLTEGIPLA 579

  Fly   582 -SSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD-VTGK-NTALHLCALHD 643
             ..:.|||||||||.....::|||||||:||            :|.|| .|.| :||||.|.|.|
Frog   580 NGHEQGETALHLAVRSVDRNSLHIVDFLVQN------------SGNLDKQTAKGSTALHYCCLTD 632

  Fly   644 RRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNED 708
            ..||:|||||..|..::.|...:|.|||||.:.|..|.:|:..|:....:|..|:..:|.|.:.|
Frog   633 NAECLKLLLRGKASTDIANDAGETPLDIAKRLKHAQCEDLLIQAMNGRFNAHVHVEYEWRLHHMD 697

  Fly   709 GSTDFSDDETVIDER-------KSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFT 766
              .|.|||:  :||:       :...||.||.|     :.....:...:...::.||....|.|
Frog   698 --LDESDDD--MDEKIQQPSPIRREERPVSFFG-----INQGQPSVACLAREAASIAKDKPRTF- 752

  Fly   767 LPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDL 831
            ||:.:.:.|:            |..:|::     |.||| .:.||:.::..: ..||::.:.|.:
Frog   753 LPNIIQNETY------------GAVIGNS-----NSPGN-ATGPSTTNAPPL-PPRNTIKVHSTI 798

  Fly   832 GGHV-------TGARKSTSTANMNSLKKRTA--------PAPPPGTLGSASSSSFYGTLPHPPRH 881
            .|..       |.|.|::|....:..::|::        |.||.....:|::|      |.||..
Frog   799 FGSSIHPTPSNTPAWKASSVTPESGSRQRSSSDPPSIQPPVPPVRVTSTATNS------PPPPPV 857

  Fly   882 SQNFDASDIRAIN-HKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPA 945
            ::.  ||.|.|:: |..||
Frog   858 TKT--ASVIEALSQHSKQS---------------------------------------------- 874

  Fly   946 MTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRP--KIPPPG----PPSER 1004
                    .|....||        |.|.||....|.         .||  |.|.||    ||:.:
Frog   875 --------PPPPVPLN--------KPVPPPVPPQPA---------NRPLHKRPAPGIDKPPPTAK 914

  Fly  1005 EISNGQSNESISSMDEGP-----VAPPRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESNVSSS 1064
                            ||     .|||    :.:|.||                          |
Frog   915 ----------------GPPPALVTAPP----SAAAEFP--------------------------S 933

  Fly  1065 DNDRL--NSSPDN--------PSKTGGAGLGGKFHYNGQRRCRALYDCVADNDDELEFKEGEILI 1119
            |...|  .|.|.|        |.|:       :......:|.:|:|.|.|||.|||.|.||||::
Frog   934 DTTALQPGSKPSNRTQPPAPMPRKS-------QLPKMKPKRVKAIYHCSADNPDELTFSEGEIIV 991

  Fly  1120 VLNERTDDENWMEGIIEGQPTRKGMFPVSFVHMLPD 1155
            |..|  :|:.|..|.|:|:|.|:|.|||||||.:.:
Frog   992 VDGE--EDKEWWIGHIDGEPNRRGAFPVSFVHFIAE 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	124/213 (58%)
		PH_ASAP	302..410	CDD:270071	60/107 (56%)
		ArfGap_ASAP	425..541	CDD:350063	63/118 (53%)
		Ank_2	554..662	CDD:403870	51/112 (46%)
		ANK repeat	586..622	CDD:293786	18/35 (51%)
		ANK repeat	624..662	CDD:293786	20/39 (51%)
		Ank_2	636..>693	CDD:403870	24/56 (43%)
		SH3_ASAP	1095..1149	CDD:212755	28/53 (53%)
asap2	XP_002935078.3	BAR_ASAP2	34..248	CDD:153326	124/213 (58%)
		PH_ASAP	297..403	CDD:270071	60/107 (56%)
		ArfGap_ASAP2	419..541	CDD:350074	64/122 (52%)
		ANKYR	498..676	CDD:223738	77/189 (41%)
		ANK repeat	550..582	CDD:293786	13/31 (42%)
		ANK repeat	585..618	CDD:293786	21/44 (48%)
		ANK repeat	620..651	CDD:293786	16/30 (53%)
		PHA02682	<902..>980	CDD:177464	28/130 (22%)
		SH3_ASAP2	967..1022	CDD:212899	31/56 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1708
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	752	1.000	Inparanoid score	I561
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm48598
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10447
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110