DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and agap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_004917925.2	Gene:	agap1 / 100485248	XenbaseID:	XB-GENE-981023	Length:	1203	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	112/465 - (24%)
Similarity:	179/465 - (38%)	Gaps:	132/465 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 STPDFERVD-------NVPSSESRSGGAGYSLHQLQGDKHHG----------------------- 310
            |...|.|:|       :|.|::..|.||..:...:..|...|
Frog   775 SLGSFSRMDGMHQRSYSVSSADQWSEGAVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSP 839

  Fly   311 -VTRQGHLLKKS-------------EGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTC 361
             ..|:.|..|||             |.| |:.|:..|.....:.:....:.:|.
Frog   840 HANRKKHRRKKSTSNFKADGLSSTAEAK-RKAWKLNRVGSLRNVYSSNANTEEQ----------- 892

  Fly   362 QIKPVPDDKRGFDLISY-NRPYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQHANPQMSPSLVEL 425
                  ::...|.::|. ::.:||:|....::.||:..:    |..:..:.|......:.|.:..
Frog   893 ------EENFEFIIVSLTSQSWHFEATSYEERDAWVQAI----ESQILASLQSCESSKNKSRLTS 947

  Fly   426 QK--TVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNL 488
            |.  ..::.::.||||..|.||.::|. .|.|||.|.|:||:|||:||:||.|.||::||.||:.
Frog   948 QNEALALQSIRNLPGNSHCVDCDAQNP-DWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDW 1011

  Fly   489 TTANLLIARAMGNSTLNDIME-AKLGRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRC 552
            ....:.:..|:||...|.:.| :..|..|...||..||:..:|||||..|.::......|..|..
Frog  1012 PPELIKVMSAIGNELANSVWEGSSQGHVKPCSESPREEKERWIRAKYEQKLFLSPLPCRDLPLGQ 1076

  Fly   553 DLEQAVVNADMSQLLQVWAEGA----DLTCCLPSSDAGE----TALHLAVLREMGSTLHIVDFLI 609
            .|.:|....|:..::.:.|.|:    :.||       ||    |:||||.
Frog  1077 QLLRATAEEDLRAVILLLAHGSREEVNETC-------GEGDRRTSLHLAC--------------- 1119

  Fly   610 QNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKE 674
                .||                |..|           ::||:..|.|...::....|||..||:
Frog  1120 ----RKG----------------NVVL-----------VQLLIWYGVDVMARDFHGNTALAYAKQ 1153

  Fly   675 MGHNSCRELI 684
            ...:..|||:
Frog  1154 AVTSEVRELL 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	21/145 (14%)
		ArfGap_ASAP	425..541	CDD:350063	48/118 (41%)
		Ank_2	554..662	CDD:403870	22/115 (19%)
		ANK repeat	586..622	CDD:293786	9/39 (23%)
		ANK repeat	624..662	CDD:293786	6/37 (16%)
		Ank_2	636..>693	CDD:403870	13/49 (27%)
		SH3_ASAP	1095..1149	CDD:212755
agap1	XP_004917925.2	Centaurin_gamma	382..543	CDD:133303
		PH_AGAP	658..934	CDD:241281	30/180 (17%)
		ArfGap_AGAP	953..1059	CDD:350065	45/106 (42%)
		ANK repeat	1078..1108	CDD:293786	7/36 (19%)
		Ank_5	1093..1151	CDD:404699	22/110 (20%)
		ANK repeat	1110..1141	CDD:293786	13/76 (17%)
		ANK repeat	1143..1168	CDD:293786	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010