DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and asap1a

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005163531.1	Gene:	asap1a / 100170829	ZFINID:	ZDB-GENE-070912-129	Length:	1154	Species:	Danio rerio

Alignment Length:	1230	Identity:	475/1230 - (38%)
Similarity:	667/1230 - (54%)	Gaps:	174/1230 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGN 67
            |..|:||||:.||..||:|||||:|.:|:..||:|:.||||.|:.||..|.|:||:||||:|||.
Zfish    22 PDQISVSEFLSETTEDYNSPTTSSFTTRLQSCRNTVNVLEEALDQDRTALQKVKKSVKAIYNSGQ 86

  Fly    68 THVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSML 132
            .||.||....:||::.|...|.:|..|:|.||:|||.:.|||:||:|.|:|::::.|:|.:||:|
Zfish    87 EHVQNEENYGQALDKFGSNFISRDNSDLGTAFIKFSGLIKELAALLKNLLQSLSHNVIFTLDSLL 151

  Fly   133 KSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197
            |.:|:|||||:|:|||||.||||.||.||||||:..||:.||:||||..|.:|||||||||::||
Zfish   152 KGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRIFQL 216

  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262
            |.||||:|..:||||.|::|||:||:||||..|:|:|||:|.:....||..|:..|:.|||.|||
Zfish   217 QMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDE 281

  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRR 327
            :::.|..||.:::|:...::.::...|:|:.  :|||:|||||:|..|..::|:|.|||:| :|:
Zfish   282 EKKQLTALRDLIKSSLQLDQKESRRDSQSKQ--SGYSMHQLQGNKEFGSEKKGYLFKKSDG-IRK 343

  Fly   328 VWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGDQ 392
            |||:|:|.| .:|.|.|.||..::.|.|:||||||:||..:||:.|||||:||.||||||||.:.
Zfish   344 VWQRRKCSV-KNGILTISHATSNRQPVRLNLLTCQVKPSGEDKKCFDLISHNRTYHFQAEDEQEF 407

  Fly   393 KAWMAVLVNCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLN 457
            ..|::||.|.||:||..||:........||.:|.|.:|..|..:|||:.|||||: .:..|:|.|
Zfish   408 VIWISVLTNSKEEALNMAFRGEQSAGDDSLEDLTKAIIEDVLRIPGNEVCCDCGA-PEPKWLSTN 471

  Fly   458 FGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKL--GRGKLQHE 520
            .|||.||:|||:||::|||.|||||:.||.|.|:.||:|:.:|||:.|:|:|..|  ...|....
Zfish   472 LGILTCIECSGIHREMGVHISRIQSMELDKLGTSELLLAKNVGNSSFNEILEGNLPSPSPKPAPS 536

  Fly   521 SSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPSS-- 583
            |.|.||.::|.||||..|:..||.:.....:.||.:||...|:..|:|::|:|.:|....|.:
Zfish   537 SDMTERKEYINAKYVEHRFARRTATTATARQGDLYEAVRTRDLMALIQLYADGVELMDPFPEAGQ 601

  Fly   584 DAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD--VTGKNTALHLCALHDRRE 646
            |.||||||.||.....::||:||||:||            :|.||  ....|.|||.|..:::.|
Zfish   602 DPGETALHFAVRTSDQTSLHLVDFLVQN------------SGTLDRQTESGNAALHYCCTYEKPE 654

  Fly   647 CMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGST 711
            |:|||||.....:|.|...:||||||:.:.:..|.||:..|.....:...|:..:|||..|:  .
Zfish   655 CLKLLLRGKPSIDLVNQNGETALDIARRLRNVQCEELLVEAAAGRFNPHVHVEYEWNLRLEE--I 717

  Fly   712 DFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSGLPSYTH 776
            |.|||:  :|::            .|||.:.||....|...|||.   .|..:.|||..|
Zfish   718 DESDDD--LDDK------------PSPVKKERSPRPQSFCHSSSV---SPQEKLTLPGYL----- 760

  Fly   777 SAGTSPKQHISVGQYLGSATNVGGNGPGNGGS-SPSSASSQSVRA------ARNSLNMQSDLGGH 834
              |...||.:|.|.:.....:.....|.:..| .|:.||....:|      ....|..||..||.
Zfish   761 --GHRDKQRLSYGAFANPVYSTSTETPASPVSEGPTIASKTPAKAPSCGPPTSLPLGSQSSAGGS 823

  Fly   835 VTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDIRAINHKNQS 899
            .|             |.|:.||.||||                   |.:          .|.:..
Zfish   824 ST-------------LSKKRAPPPPPG-------------------HKR----------THSDPP 846

  Fly   900 LDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNG----SNNSLMPAMTTFGHK---RSPSG 957
            ..|..|  |..:..||:|....      ...|.....|    .:.:.|....|||.:   :.|..
Zfish   847 SPVLQG--PQSKGSESTPPSAN------RTSPANKFEGIQQQQSTTSMNTKATFGPRVLPKLPQK 903

  Fly   958 ESLNR--NIHLAGAK------LVLPPTG-ELPTLKHVDKSALTR-----PKIP------------ 996
            .:|.:  .|||....      |..||.. :.|..:..|  .:||     ||||
Zfish   904 VALRKIDTIHLPSVDKSGPDVLQKPPQAQDAPPTRASD--TITRPTEPPPKIPQVAERSQPVDVP 966

  Fly   997 --------PPGP-----PSEREISNGQSNESISSMDEGPV---APPRKLVNQSANFPDY--ESWH 1043
                    ||.|     |.:.::|:......:|.:...|.   .||:..::...:.|..  .|..
Zfish   967 QKPHISDLPPKPQLSDLPPKPQLSDLPPKPQLSDLPPKPQLKDLPPKPQISDLPSKPAVCSASEA 1031

  Fly  1044 TDMDSSGGGLDHSAESNVSSSDNDRLNSSPDNPSK-TGGAGLGG---------KFH---YNGQRR 1095
            |...|:........:...:.|.:.:...||...|: |.||..|.         |.:   .|..:|
Zfish  1032 TQRQSTQEETSPKPQLTETQSFSQQEELSPRQASEDTNGAPAGALEMPVPMPRKINTVAKNKAKR 1096

  Fly  1096 CRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGIIEGQPTRKGMFPVSFVHMLPD 1155
            .:.:|||.|||||||.|.|||::||..|  :|:.|..|.|||||.|||:||:||||:|.|
Zfish  1097 VKTIYDCQADNDDELTFVEGEVIIVTGE--EDQEWWIGHIEGQPERKGVFPMSFVHILSD 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	122/213 (57%)
		PH_ASAP	302..410	CDD:270071	59/107 (55%)
		ArfGap_ASAP	425..541	CDD:350063	58/117 (50%)
		Ank_2	554..662	CDD:403870	43/111 (39%)
		ANK repeat	586..622	CDD:293786	16/35 (46%)
		ANK repeat	624..662	CDD:293786	16/39 (41%)
		Ank_2	636..>693	CDD:403870	22/56 (39%)
		SH3_ASAP	1095..1149	CDD:212755	31/53 (58%)
asap1a	XP_005163531.1	BAR_ASAP1	54..268	CDD:153325	122/213 (57%)
		PH_ASAP	319..425	CDD:270071	59/107 (55%)
		PH	329..414	CDD:278594	46/86 (53%)
		ArfGap	442..553	CDD:279720	56/111 (50%)
		ANK	570..693	CDD:238125	53/134 (40%)
		ANK repeat	604..637	CDD:293786	19/44 (43%)
		Ank_2	608..697	CDD:289560	39/100 (39%)
		ANK repeat	639..670	CDD:293786	13/30 (43%)
		ANK repeat	672..697	CDD:293786	10/24 (42%)
		Tankyrase_bdg_C	883..1044	CDD:291973	33/162 (20%)
		TonB_N	916..1045	CDD:292650	24/130 (18%)
		SH3_ASAP1	1096..1152	CDD:212898	35/57 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	767	1.000	Inparanoid score	I524
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm24323
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980