DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and smap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001120382.1	Gene:	smap1 / 100145457	XenbaseID:	XB-GENE-979112	Length:	471	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	120/523 - (22%)
Similarity:	192/523 - (36%)	Gaps:	119/523 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 KEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCS 467
            :|||..:..||             :.::..:.....|..|.||.::.. .|.|.|.|:.:||:|:
Frog     7 REKAQKQNEQH-------------QAILSRMLREEDNKYCADCEAKGP-RWASWNLGVFICIRCA 57

  Fly   468 GVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRG--KLQHESSMEERYDFI 530
            |:||:||||.||::|:.||..|...:...:.|||:....:.||.|...  :.|.:.|:|   .||
Frog    58 GIHRNLGVHISRVKSVNLDQWTPEQMQCMQDMGNTKARQMYEANLPENFRRPQTDQSVE---FFI 119

  Fly   531 RAKYVAKRYVMR-------TCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGET 588
            |.||..|:|..:       |.|.|         ||..:..|..||..||.:.|     ..:....
Frog   120 RDKYERKKYYDKNATVPGITSSSD---------AVQPSASSPSLQSAAEKSKL-----EKEKDRK 170

  Fly   589 ALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRE--CMKLL 651
            .......||               |.|.|    .|.|...|..|...|.:.|...:..  .:.||
Frog   171 KEERKKERE---------------PEKSL----KPVGADKVLKKELPLEVKASPKKSPELTVDLL 216

  Fly   652 -LRSGADYELKNSQNKTA------LDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDG 709
             |.:.|:..:.|....|.      |||...|..|...  :..|...:.::.:..:|  ::.:..|
Frog   217 GLDAPAETSVSNGNTSTIAGVNDDLDIFGPMVSNPIP--VSAAPPTQDTSTNPAST--SISSSSG 277

  Fly   710 STDFSDDETVIDE---RKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFT-LPS- 769
            ..|...|:|...|   :|..|:....:...:..::.:::|...:..|..|.:..|:..|. .||
Frog   278 DLDLFTDQTTKSEETQKKPLSKDSILSLYGTTNMQQQNTTGMFMGPSPMPYSAQPTASFQGFPSM 342

  Fly   770 GLPSYTHSAGTSPKQHISVGQYLG------------SATNVGGNGPGNG----------GSSPSS 812
            |:|             |:.|..:|            ||..:.|.|..||          |..||.
Frog   343 GVP-------------IAAGGIMGNMMGPSVPGMGQSAGMMVGMGMPNGFVANASAGVMGLPPSM 394

  Fly   813 ASSQ-----SVRAARNSLNMQSDLGG--HVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSS 870
            ...|     ::...:|...|..:...  :::...:..|..|:|......|...|..|:|...:.|
Frog   395 IGPQAGMVGNMATPQNKFGMPQNQPSPWNLSQMNQQMSGLNLNGASNMMAFGQPANTVGGGWAGS 459

  Fly   871 FYG 873
            ..|
Frog   460 ATG 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	3/6 (50%)
		ArfGap_ASAP	425..541	CDD:350063	40/117 (34%)
		Ank_2	554..662	CDD:403870	23/110 (21%)
		ANK repeat	586..622	CDD:293786	5/35 (14%)
		ANK repeat	624..662	CDD:293786	9/40 (23%)
		Ank_2	636..>693	CDD:403870	14/65 (22%)
		SH3_ASAP	1095..1149	CDD:212755
smap1	NP_001120382.1	ArfGap_SMAP	21..123	CDD:350068	36/105 (34%)
smap1	NP_001120382.1	Med15	<312..>454	CDD:312941	30/154 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910