Protein Alignment Cul4 and Cul4a

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_666319.2
• Gene: Cul4a / 99375
• MGIID: 1914487
• Length: 759
• Species: Mus musculus
• Alignment Length: 759
• Identity: 488/759 - (64%)
• Similarity: 590/759 - (77%)
• Gaps: 10/759 - (1%)

  Fly    69 GGSHGEIRTASTTSNLLNRMGAIHN--SKPGDV---KKIVIKNFKDKPTLPDNYSKDTYVKLEEA 128
            |...|.:......:|.|.:..|:..  :|||..   :|:|||||:|:|.|||||::||:.||.||
Mouse     5 GPRKGSVSALMGRTNGLTKPAALAGGPAKPGGTGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEA 69

  Fly   129 VIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNI-KLKELTGGSMDKLIL 192
            |.|||.|..|:|:||||||||.|:||||:...||.:|:::.|.||:..| ..:|   .|:|.::.
Mouse    70 VKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPFRE---DSLDSVLF 131

  Fly   193 LEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGL 257
            |:|||..|...|:||||||||||::|||||||||.:.|||||||:|||.|...:.:||.:|:||:
Mouse   132 LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGI 196

  Fly   258 LTLIEKERQGSTVDRGLLKSLVRMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQ 322
            |.||.:||.|..|||.||:||:.||.|||:|..|||.|||:.||.||.||.||.||:.||||||.
Mouse   197 LLLIGRERSGEAVDRSLLRSLLSMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLN 261

  Fly   323 HVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLL 387
            ||:|||.||.:|:..|||.||:.|||..|||:||.||||:||||||:.||::||:.|||.:|.|.
Mouse   262 HVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEHLLDENRVPDLTQMYQLF 326

  Fly   388 SRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLR 452
            ||||.|...|..:::.:||..|.||||:|||||.|||||||||||:|.:|..||:.||:|.|.::
Mouse   327 SRVKGGQHALLQHWSEYIKTFGTTIVINPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMK 391

  Fly   453 EAFEFFINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKD 517
            |:||.|||:|.|||||||||:||.|||:|||..||||||:.|||||:||||||||||||||||||
Mouse   392 ESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKD 456

  Fly   518 LAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHN 582
            ||||||||||||||:|||||||||.|||..|||||||||||||||:||.:.|:.| :.|......
Mouse   457 LAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQH-MQNQSAPGP 520

  Fly   583 LDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAG 647
            :||.|:||||||||||.|.||.:||:.:..|::|..|||.||||||||||.|||:.:|:|.|..|
Mouse   521 IDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEG 585

  Fly   648 PKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILD 712
            .||..|||||.||||:||:....|:|||..||.|||.||||||||||||:|||:.|:|||:|:.|
Mouse   586 KKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVED 650

  Fly   713 GDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLL 777
            ||:|.||.:|.:|||||||||||||||.|||.:|.|||||||||||||||||||||||||.||||
Mouse   651 GDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLL 715

  Fly   778 ITELFNQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ::||:|||.|||||.||||||||||||||||||||:.|||:|||
Mouse   716 VSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	380/598 (64%)
		Cullin_Nedd8	753..813	CDD:463146	53/59 (90%)
Cul4a	NP_666319.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		8/34 (24%)
		Cullin	63..660	CDD:459983	380/600 (63%)
		Cullin_Nedd8	688..753	CDD:214883	57/64 (89%)