DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and CDC53

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_010150.1	Gene:	CDC53 / 851424	SGDID:	S000002290	Length:	815	Species:	Saccharomyces cerevisiae

Alignment Length:	803	Identity:	194/803 - (24%)
Similarity:	338/803 - (42%)	Gaps:	142/803 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 QLSKPIKYSLEELYQAVVNMCSHK-------------------MDAQLYAKLKELTEQHVKRNIK 178
            ::..|..|.  |:|.|:.|.|.:|                   :.:::|.|||...:.::   :.
Yeast    41 KILSPTMYM--EVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNYI---LN 100

  Fly   179 LKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNST--VHSIWDMG----LD 237
            .|:    |..:..|...:.. |..|....|.:...|.||:|.:|.:..:  ...|:|:.    :.
Yeast   101 FKQ----SNSETFLQFYVKR-WKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMT 160

  Fly   238 LFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRG----LLKSLVRMLCD--------LQIYTS 290
            ...:.|..:..|   .::.||..:...|:|..:.|.    .:||||.:..|        |.:|..
Yeast   161 WKEVMFDPSKDV---LINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQ 222

  Fly   291 SFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKEL 355
            .||:.||..|.:.|...:...:::..|.||:...::.:..|.:.:..|.|..||.||...:.|.|
Yeast   223 VFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVL 287

  Fly   356 LAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTIV------- 413
            :.:|:.. |:.....||:...:..:|.||.|:.|.......:...|..::||.|...:
Yeast   288 ITDHIEK-LENEFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMH 351

  Fly   414 ---------IDPEK----------DKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFI 459
                     .:|:|          .|..::.||:..|....|....|..:.....:|..|...||
Yeast   352 KHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFI 416

  Fly   460 N------------QRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEA 512
            |            ...:|.:|::|||.|:.|:...|.....::..  :.|:.:|:::..||.||.
Yeast   417 NINEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSD--EDIITIFKYLTDKDAFET 479

  Fly   513 FYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNN 577
            .|::..||||:.|.|.|.:.|::::.:|:......:|.|:..||:|:.||:.:...| ..||.|.
Yeast   480 HYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDF-AVALKNE 543

  Fly   578 RDVHNL---DLCVSILTMGYWP-TYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNC 638
            .|....   ||...:|....|| :|...|..:|.:.:...:...:.|.:||:||.|:|...|  |
Yeast   544 PDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLWPL--C 606

  Fly   639 MLRAQFDAG-----PKELLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACG-- 696
            ....:.|.|     |....|:|||..:|||:||..||:.|.|...|.:       |:|.:|..
Yeast   607 RGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLENIQEGTSL-------TIQHIAAAMV 664

  Fly   697 ---RARVITKTPKGREILDGDQFDFNNEFTNKLFRIKI-----------------------NQIQ 735
               :.::|.:.|.|.:.|...:..|......|..:..|                       |::.
Yeast   665 PFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVKNDILQSLSGGGHDNHGNKLG 729

  Fly   736 MKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQ--LTFPVKPADLKKRI 798
            .|...|::: .|:.:..:||..::|.||||||.::.|.|..|:.|...|  ..|..|.:.:|:.|
Yeast   730 NKRLTEDER-IEKELNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAI 793

  Fly   799 ESLIDRDYMERDKDNQNQYNYVA 821
            :|||.:.|::|..|.:: |.|:|
Yeast   794 DSLIQKGYLQRGDDGES-YAYLA 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	161/676 (24%)
		CULLIN	503..644	CDD:214545	43/144 (30%)
		Cullin_Nedd8	750..815	CDD:214883	24/66 (36%)
CDC53	NP_010150.1	COG5647	7..815	CDD:227934	193/801 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820