DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul4 and CUL2

DIOPT Version :9

Sequence 1:NP_001163084.1 Gene:Cul4 / 35780 FlyBaseID:FBgn0033260 Length:821 Species:Drosophila melanogaster
Sequence 2:XP_011518045.1 Gene:CUL2 / 8453 HGNCID:2552 Length:808 Species:Homo sapiens


Alignment Length:810 Identity:229/810 - (28%)
Similarity:391/810 - (48%) Gaps:78/810 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 SHGEIR------TASTTSNLLNRMGAIHNSKPGDVKKIVIKNF----KDKPTLPDNYSKDTYVKL 125
            :||::.      ...:|..|:...|.:.....||....:.:::    ..||.:.|  ..:|:.||
Human    18 THGDMERKPCDIERKSTGQLIGENGTLLYPDCGDGHAWLFQHYTCTMSLKPRVVD--FDETWNKL 80

  Fly   126 EEAVIAIQLSKPI-KYSLEELYQAVVNMC---SHKMDAQLYAKLKELTEQHV----KRNIKLKEL 182
            ...:.|:.:.:.: :.:..:.:..:..:|   ...:..:||.:.|...|.||    ||.::.:|.
Human    81 LTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQ 145

  Fly   183 TGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHS----------------- 230
                     :|...:.:|..:.:....:..::.|::..::.:|....:                 
Human   146 ---------VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLME 201

  Fly   231 IWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQG----STVDRGLLKSLV-----RMLCDLQ 286
            |.::.||::|....:  .:|...:..||..|:.:|.|    ..|..|::.|.|     :....|:
Human   202 IGELALDMWRKLMVE--PLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLK 264

  Fly   287 IYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNV 351
            .|...||..||..|.:.||.|:...:||....:|::.|..||.:|..|.|.||..|:...:|:..
Human   265 FYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHEC 329

  Fly   352 EKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKG--RTIVI 414
            ::.::|:|| ..|.....:::...:.:|:..:|.||..|..|...:.......|..:|  .|..:
Human   330 QQRMVADHL-QFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL 393

  Fly   415 DPEKDKSM-VQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPA----ELIAKYV 474
            ..|...:: |:.:|:...|...::.|....::.|.::|.:|....:|.|..|..    ||:|||.
Human   394 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYC 458

  Fly   475 DMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSK 539
            |..|:...||.|:.|:|..|...:.:|::|..||||:.||.:.|||||:.|.|.|:|||::|::|
Human   459 DNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINK 523

  Fly   540 LKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVS----ILTMGYWP-TYA 599
            |||.||..|||||..|:.||.:|.|:|..|..  ...|:|. .:||.:|    :|..|.|| |.|
Human   524 LKQACGYEFTSKLHRMYTDMSVSADLNNKFNN--FIKNQDT-VIDLGISFQIYVLQAGAWPLTQA 585

  Fly   600 PTEVTMPPQFINPQ-QIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLL 663
            |:.....||.:... |:|..||.:..|||||.|...|....::..:...|...:|:.:|..|||.
Human   586 PSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLA 650

  Fly   664 FNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNEFTNKLFR 728
            ||:...:||:|:..:|.:.:.||.:|::||.  ..::|....:..:|.....|..|..|::|..:
Human   651 FNNSETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRTK 713

  Fly   729 IKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKP-- 791
            .||.....|:|.:|.:.|...|.:||:..:.||||||||.||.|.||.||.|:.:|......|  
Human   714 FKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSI 778

  Fly   792 ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            :.:||.||.|||:.|:||.:.:.::|:|||
Human   779 SMIKKCIEVLIDKQYIERSQASADEYSYVA 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul4NP_001163084.1 Cullin 124..721 CDD:279260 175/643 (27%)
CULLIN 503..644 CDD:214545 62/146 (42%)
Cullin_Nedd8 750..815 CDD:214883 31/66 (47%)
CUL2XP_011518045.1 Cullin 93..706 CDD:279260 172/629 (27%)
CULLIN 487..631 CDD:214545 62/146 (42%)
Cullin_Nedd8 735..802 CDD:214883 31/66 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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