DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and CUL3B

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001319357.1	Gene:	CUL3B / 843303	AraportID:	AT1G69670	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	732	Identity:	288/732 - (39%)
Similarity:	430/732 - (58%)	Gaps:	24/732 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 IKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKEL 168
            |:.||.:..:...|:..|:..||.|:..|........|.||||:...||..||...:||..|...
plant    11 IEAFKQRVVVDPKYADKTWKILEHAIHEIYNHNASGLSFEELYRNAYNMVLHKYGDKLYTGLVTT 75

  Fly   169 TEQHVKRNIK-LKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIW 232
            ...|:|...| ::|..||:     .||.:|..|....:.:.|||.|.:|||||||......| :.
plant    76 MTFHLKEICKSIEEAQGGA-----FLELLNRKWNDHNKALQMIRDILMYMDRTYVSTTKKTH-VH 134

  Fly   233 DMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDL--QIYTSSFEEK 295
            ::||.|:|.:...:|.:|.|.::.||.|:.|||.|..:||.|::::::|..||  .:|...||:.
plant   135 ELGLHLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVIDRVLMRNVIKMFMDLGESVYQDDFEKP 199

  Fly   296 FLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHL 360
            ||:|:.:.||.||...::..:..|||:...|.|.||.||:.:|||:.::..:...||:|::|.|:
plant   200 FLEASAEFYKVESMEFIESCDCGEYLKKAEKPLVEEVERVVNYLDAKSEAKITSVVEREMIANHV 264

  Fly   361 TSIL---QKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDK-- 420
            ..::   ..||.::|.:::..|:..:|.|..||.||...:.......:::.|:.:|.||||.|
plant   265 QRLVHMENSGLVNMLLNDKYEDMGRMYSLFRRVANGLVTVRDVMTLHLREMGKQLVTDPEKSKDP 329

  Fly   421 -SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPAELIAKYVDMKLRSGNKG 484
             ..||.|||.:||.|.|:...|.:::.|.|:|..:||:|:|.....| |.|:.:||.|||.|.||
plant   330 VEFVQRLLDERDKYDRIINMAFNNDKTFQNALNSSFEYFVNLNTRSP-EFISLFVDDKLRKGLKG 393

  Fly   485 TTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFT 549
            ..:|:::..|||:|:|||::..|||||.:||:.||||||.||:.|.|:|::::.|||.|||..||
plant   394 VGEEDVDLILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERNLIVKLKTECGYQFT 458

  Fly   550 SKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQ 614
            |||||||.||:.|.|..:.|..   |:........|.|.:||.|.|||....:..:|.:.....:
plant   459 SKLEGMFTDMKTSHDTLLGFYN---SHPELSEGPTLVVQVLTTGSWPTQPTIQCNLPAEVSVLCE 520

  Fly   615 IFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPK-ELLVSLFQALVLLLFNDKPVLSYEEILAA 678
            .|..:||..|:||:|.||..:|...::|.|..|.| ||.||.||..||:|||:...|||:||..|
plant   521 KFRSYYLGTHTGRRLSWQTNMGTADIKAVFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQA 585

  Fly   679 TLIEDGELRRTLQSLACGRAR-VITKTPKGREILDGDQFDFNNEFTNKLFRIKINQ-IQMKETNE 741
            |.|...:|:|.|||:||.:.: |:.|.|..:||.:.|.|..|:.|.:|.:::||.. :..|||..
plant   586 TEIPTPDLKRCLQSMACVKGKNVLRKEPMSKEIAEEDWFVVNDRFASKFYKVKIGTVVAQKETEP 650

  Fly   742 EQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQL--TFPVKPADLKKRIESLIDR 804
            |::.|.:||.:||:.||:||||||||.|:.|.||.:|.|:..||  .|...|.::||||||||:|
plant   651 EKQETRQRVEEDRKPQIEAAIVRIMKSRRVLDHNNIIAEVTKQLQTRFLANPTEIKKRIESLIER 715

  Fly   805 DYMERDKDNQNQYNYVA 821
            |::|||..::..|.|:|
plant   716 DFLERDNTDRKLYRYLA 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	234/607 (39%)
		CULLIN	503..644	CDD:214545	59/140 (42%)
		Cullin_Nedd8	750..815	CDD:214883	36/66 (55%)
CUL3B	NP_001319357.1	Cullin	29..630	CDD:366357	234/610 (38%)
CUL3B	NP_001319357.1	Cullin_Nedd8	659..726	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830