DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and CUL2

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001318910.1	Gene:	CUL2 / 839415	AraportID:	AT1G02980	Length:	742	Species:	Arabidopsis thaliana

Alignment Length:	757	Identity:	249/757 - (32%)
Similarity:	396/757 - (52%)	Gaps:	72/757 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KDTYVKLEEAVIAIQLSKPIKYSLEE--------------LYQAVVNMCSHK----MDAQLYAKL 165
            ||:.::...:|:...::| ::..|||              ||..|.|:|:.|    ...|:|.:.
plant     4 KDSVLEAGWSVMEAGVAK-LQKILEEVPDEPPFDPVQRMQLYTTVHNLCTQKPPNDYSQQIYDRY 67

  Fly   166 KELTEQHVKRNI--KLKELTGGSMDKLILLEKINHWWLSFCQQMIMIR---SIFLYMDRTYVLQN 225
            ..:...:.|:.:  .::|..|    :.:|.|.:..|    ..|.|::|   ..|.|:||.|..:.
plant    68 GGVYVDYNKQTVLPAIREKHG----EYMLRELVKRW----ANQKILVRWLSHFFEYLDRFYTRRG 124

  Fly   226 S--TVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLC----- 283
            |  |:.::   |...||....|.  :|.:..|.:|.||.|||:|..:||.|||:::.:.|
plant   125 SHPTLSAV---GFISFRDLVYQE--LQSKAKDAVLALIHKEREGEQIDRALLKNVIDVYCGNGMG 184

  Fly   284 DLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLI 348
            :|..|...||...|:.:...|...:.|..||...|:|:....:.|..|.||:.:||.|:|:..|:
plant   185 ELVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEKERVTNYLHSTTEPKLV 249

  Fly   349 YNVEKELL---AEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGR 410
            ..|:.|||   |:.|......|..:||.|:::.||..:|.|...:..|...:...|...|..:|.
plant   250 AKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYRLYHPIPQGLDPVADLFKQHITVEGS 314

  Fly   411 TIVIDPE---------------KDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFIN 460
            .::....               :|:.:::.|:|..||..|.|..||:.:..|..:|:||||.|.|
plant   315 ALIKQATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDECFQKHSLFHKALKEAFEVFCN 379

  Fly   461 QRAN--KPAELIAKYVDMKLRSGN--KGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKR 521
            :...  ..||::|.|.|..|::|.  :...:|:||.||:|::.|..:|..||:|..|::|..|:|
plant   380 KTVAGVSSAEILATYCDNILKTGGGIEKLENEDLELTLEKVVKLLVYISDKDLFAEFFRKKQARR 444

  Fly   522 LLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLC 586
            ||..::.:...|:|:|:|.|:..|..||||:|||..||.|:::....|......|......:|..
plant   445 LLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAKEHQTNFVEFLSVNKTKKLGMDFT 509

  Fly   587 VSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKEL 651
            |::||.|:||:|..|::.:|.:.:|..:.|..:|..|.:.|:|.|..:||.|.|..:||....|:
plant   510 VTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRRLSWIYSLGTCQLAGKFDKKTIEI 574

  Fly   652 LVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQF 716
            :|:.:||.||||||:...|||.|||....:...:|.|.|.||:|.:.:::.|.|..|.|.:.|.|
plant   575 VVTTYQAAVLLLFNNTERLSYTEILEQLNLGHEDLARLLHSLSCLKYKILIKEPMSRNISNTDTF 639

  Fly   717 DFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITEL 781
            :||::||:|:.||::....|    :|:|...|.|.:||:|.||||:|||||.||.|.|..|::|.
plant   640 EFNSKFTDKMRRIRVPLPPM----DERKKIVEDVDKDRRYAIDAALVRIMKSRKVLGHQQLVSEC 700

  Fly   782 FNQLTFPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ...|:...||  ..:|||||.||.|||:|||.||.|.:.|:|
plant   701 VEHLSKMFKPDIKMIKKRIEDLISRDYLERDTDNPNTFKYLA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	198/648 (31%)
		CULLIN	503..644	CDD:214545	49/140 (35%)
		Cullin_Nedd8	750..815	CDD:214883	37/66 (56%)
CUL2	NP_001318910.1	Cullin	12..645	CDD:366357	198/646 (31%)
CUL2	NP_001318910.1	Cullin_Nedd8	669..736	CDD:214883	37/66 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.790