DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul4 and CUL4

DIOPT Version :9

Sequence 1:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_568658.1	Gene:	CUL4 / 834663	AraportID:	AT5G46210	Length:	792	Species:	Arabidopsis thaliana

Alignment Length:	791	Identity:	419/791 - (52%)
Similarity:	554/791 - (70%)	Gaps:	11/791 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TAAAASSVGRSAFAAQNMNSASTNGERLPNF----SKLGGSHGEIRTASTTSNLLNRMGAIHNSK 95
            |.:|||:...|::::..|..|..:....|..    .|:.|.|.|.......:||..:...:
plant     9 TFSAASASDDSSYSSPPMKKAKNDLHHSPQHPNTADKVVGFHMEEDPTPAAANLSRKKATL---- 69

  Fly    96 PGDVKKIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQ 160
            |...||.|||..|.|||||.|:.::|:.||:.|:.||.|.|.|.:.||.|||||.|:|.||:|.:
plant    70 PQPTKKFVIKLNKAKPTLPTNFEENTWEKLQSAIRAIFLKKKISFDLESLYQAVDNLCLHKLDGK 134

  Fly   161 LYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQN 225
            ||.::::..|:|:  :..|:.|.|.:.|..:.|.::...|..||.||:|||||.|.:||.||:||
plant   135 LYDQIEKECEEHI--SAALQSLVGQNTDLTVFLSRVEKCWQDFCDQMLMIRSIALTLDRKYVIQN 197

  Fly   226 STVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDLQIYTS 290
            ..|.|:|:|||.|||.|.:....|::|||.|||::|||||....|:|.||..|::|...|.||..
plant   198 PNVRSLWEMGLQLFRKHLSLAPEVEQRTVKGLLSMIEKERLAEAVNRTLLSHLLKMFTALGIYME 262

  Fly   291 SFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKEL 355
            |||:.||:.|::.|.||..:.||:.:|||||:||..||.|||||...|:|:.|:.|||..||::|
plant   263 SFEKPFLEGTSEFYAAEGMKYMQQSDVPEYLKHVEGRLHEENERCILYIDAVTRKPLITTVERQL 327

  Fly   356 LAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDK 420
            |..|:..:|:||..:|::..|..||..:..|.||| |....|....:.:::|.|:.||:|.||||
plant   328 LERHILVVLEKGFTTLMDGRRTEDLQRMQTLFSRV-NALESLRQALSSYVRKTGQKIVMDEEKDK 391

  Fly   421 SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPAELIAKYVDMKLRSGNKGT 485
            .|||.|||||..:|:|....|..||.|.|:::::||..||.|.|:|||||||::|.|||:|||||
plant   392 DMVQSLLDFKASLDIIWEESFYKNESFGNTIKDSFEHLINLRQNRPAELIAKFLDEKLRAGNKGT 456

  Fly   486 TDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTS 550
            ::||||..|:|::||||||.||||||||||||||||||:|||||:|:||||:||||.|||..||:
plant   457 SEEELESVLEKVLVLFRFIQGKDVFEAFYKKDLAKRLLLGKSASIDAEKSMISKLKTECGSQFTN 521

  Fly   551 KLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQI 615
            ||||||||:|||::||.:|:..:.:..:....:::.|.:||.||||||.|.:|.:|.:....|.|
plant   522 KLEGMFKDIELSKEINESFKQSSQARTKLPSGIEMSVHVLTTGYWPTYPPMDVKLPHELNVYQDI 586

  Fly   616 FNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKPVLSYEEILAATL 680
            |.:|||.|:|||:|.||.:||:|:|:|.|..|.|||.||||||:||:||||...||:|:|..:|.
plant   587 FKEFYLSKYSGRRLMWQNSLGHCVLKADFSKGKKELAVSLFQAVVLMLFNDAMKLSFEDIKDSTS 651

  Fly   681 IEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKA 745
            |||.||||||||||||:.||:.|.||||::.|||:|:||:||...|:|||:|.||||||.||..:
plant   652 IEDKELRRTLQSLACGKVRVLQKNPKGRDVEDGDEFEFNDEFAAPLYRIKVNAIQMKETVEENTS 716

  Fly   746 TEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKPADLKKRIESLIDRDYMERD 810
            |.||||||||||||||||||||.||.|||.|||||||.||.||:|||||||||||||||:|:||:
plant   717 TTERVFQDRQYQIDAAIVRIMKTRKVLSHTLLITELFQQLKFPIKPADLKKRIESLIDREYLERE 781

  Fly   811 KDNQNQYNYVA 821
            |.|...|||:|
plant   782 KSNPQIYNYLA 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	315/596 (53%)
		CULLIN	503..644	CDD:214545	83/140 (59%)
		Cullin_Nedd8	750..815	CDD:214883	54/64 (84%)
CUL4	NP_568658.1	Cullin	96..693	CDD:395716	315/599 (53%)
CUL4	NP_568658.1	Cullin_Nedd8	724..780	CDD:402267	47/55 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	616	1.000	Domainoid score	I33
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2660
Inparanoid	1	1.050	810	1.000	Inparanoid score	I83
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0000491
OrthoInspector	1	1.000	-	-		oto3817
orthoMCL	1	0.900	-	-		OOG6_101788
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1830
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840