Protein Alignment Cul4 and CUL1

DIOPT Version :10

• Sequence 1: NP_610352.2
• Gene: Cul4 / 35780
• FlyBaseID: FBgn0033260
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_567243.1
• Gene: CUL1 / 825648
• AraportID: AT4G02570
• Length: 738
• Species: Arabidopsis thaliana
• Alignment Length: 752
• Identity: 259/752 - (34%)
• Similarity: 418/752 - (55%)
• Gaps: 72/752 - (9%)

  Fly   116 NYSKDTYVKLEEAVIAIQLSKPI----KYSLEELYQAVVNMCS----HKMDAQLYAKLKELTEQH 172
            :|.:....||:.  |...|::|.    :|.:  ||..:.|||:    |....|||.|.:|..|::
plant    13 DYMQTGITKLKR--ILEGLNEPAFDSEQYMM--LYTTIYNMCTQKPPHDYSQQLYDKYREAFEEY 73

  Fly   173 VKRNI--KLKELTGGSMDKLILLEKINHW--------WLSFCQQMIMIRSIFLYMDRTYVLQNST 227
            :...:  .|:|    ..|:.:|.|....|        |||         ..|.|:||.::.:.|
plant    74 INSTVLPALRE----KHDEFMLRELFKRWSNHKVMVRWLS---------RFFYYLDRYFIARRS- 124

  Fly   228 VHSIWDMGLDLFR--IHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCD-----L 285
            :..:.::||..||  ::...:|.|::    .::.|::|||:|..:||.|||:::.:..:     :
plant   125 LPPLNEVGLTCFRDLVYNELHSKVKQ----AVIALVDKEREGEQIDRALLKNVLDIYVEIGMGQM 185

  Fly   286 QIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYN 350
            :.|...||...|..|:..|..::...:||...|:|:....:.|.:|.||:.|||.||::..|:..
plant   186 ERYEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEK 250

  Fly   351 VEKELLAEHLTSILQK---GLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTI 412
            |:.|||....:.:|:|   |..:||.|:::.||:.:|.|..::..|...:...|...:..:|..:
plant   251 VQHELLVVFASQLLEKEHSGCRALLRDDKVDDLSRMYRLYHKILRGLEPVANIFKQHVTAEGNAL 315

  Fly   413 VIDPE-------------KDKSMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQ--R 462
            |...|             :::.:::.:::..||..|.|..||:::..|..:|:||||.|.|:  .
plant   316 VQQAEDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVA 380

  Fly   463 ANKPAELIAKYVDMKL-RSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGK 526
            .:..|||:|.:.|..| :.|::..:||.:|.||:|::.|..:|..||:|..||:|.||:|||..:
plant   381 GSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDR 445

  Fly   527 SASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILT 591
            ||:.|.|:|:|:||||:|||.||||:|||..|:.|:|:...:|..:..||......:||.|::||
plant   446 SANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPGIDLTVTVLT 510

  Fly   592 MGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLF 656
            .|:||:|...::.:|.:.|...::|..||..|...|||.|..:||.|.:..:||....||:||.:
plant   511 TGFWPSYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKFDQKAIELIVSTY 575

  Fly   657 QALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNE 721
            ||.||||||....|||.||||...:...:|.|.|.||:|.:.:::.|.|..:.:...|.|:||::
plant   576 QAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSK 640

  Fly   722 FTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLT 786
            ||:::.|||   |.:...:|.:|..|: |.:||:|.||||||||||.||.|.|..|::|...||:
plant   641 FTDRMRRIK---IPLPPVDERKKVVED-VDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLS 701

  Fly   787 FPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 821
            ...||  ..:|||:|.||.|||:||||:|.|.:.|:|
plant   702 RMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul4	NP_610352.2	Cullin	124..722	CDD:459983	208/641 (32%)
		Cullin_Nedd8	753..813	CDD:463146	36/61 (59%)
CUL1	NP_567243.1	Cullin	12..641	CDD:459983	209/649 (32%)
		Cullin_Nedd8	668..730	CDD:463146	36/61 (59%)